Diabetic peripheral neuropathy (DPN), as the most common complication of diabetes mellitus, is manifested in peripheral nerve dysfunction to a certain extent, affecting the quality of life of patients. Based on the research on the pathogenesis of DPN at home and abroad in recent years, this paper reviews the pathogenesis of DPN in the aspects of metabolism, immunity, genes and hypoglycemic drugs, so as to provide ideas for the research and treatment of DPN mechanism in the future.

To investigate the epidemiological characteristics and clinical manifestations of hypertensive intracerebral hemorrhage (HICH).

The medical record management system of People’s Hospital of Ningxia Hui Autonomous Region was used to retrieve the cases of HICH admitted from January 2012 to December 2017. The data of the cases were analyzed retrospectively according to the epidemiological and clinical characteristics.

A total of 693 cases were collected, 422 male and 271 female, of which 68 were young, 242 were middle-aged and 383 were old. The majority of Han and Hui cases are elderly patients. The incidence rate is high at 6-22 points; basal ganglia hemorrhage is the most common site of limbs; the inability of the most common symptoms of basal ganglia hemorrhage.

To prevent HICH, especially for elderly men, such as headache, dizziness, limb weakness, speech disorders and disturbance of consciousness, we should be vigilant for cerebral hemorrhage.

In the last 10 years, homocysteine (Hcy) has been regarded as a marker of cardiovascular disease and a definite risk factor for many other diseases. Hcy is biosynthesized from methionine through multiple steps and then goes through one of two major metabolic pathways: remethylation and transsulfuration. Hyperhomocysteinemia (HHcy) is a state in which too much Hcy is present in the body. The main cause of HHcy is a dysfunction of enzymes and cofactors associated with the process of Hcy biosynthesis. Other causes include excessive methionine intake, certain diseases and side effects of some drugs. HHcy is a trigger for many diseases, such as atherosclerosis, congestive heart failure, age-related macular degeneration, Alzheimer’s disease and hearing loss. There are many studies showing a positive relationship between Hcy level and various symptoms. We speculate that a high level of Hcy can be the sole reason or an aggravating factor in numerous diseases for which causal links are not fully understood.

To investigate the effect and safety of edavarone in the treatment of acute cerebral infarction.

Totally, 120 patients, admitted to Department of Neurology of Yanbian University Hospital from January 2018 to January 2019, were randomly divided into control group (60 cases) and observation group (60 cases). Both groups were given conventional treatment, but the patients in observation group were given edaravone additonally. On 14 and 21 d after treatment, the clinical effect was evaluated using the chart of ADL and NIHSS.

The therapeutic effective rates were 88.33% and 73.33% for observation group and control group, respectively. Meanwhile, significant improvement could be seen by the score of ADL and NIHSS on day 7 and day 14 after treatment in observation group, and there was significant difference between these two groups. More, no severe drug associated side-effect were observed in each group.

Edavarone can improve neurological deficits as well ADL score in acute cerebral infarction patients, resulting in good therapeutic efficacy, and it is worth of application as a safe drug.

显微血管减压术（MVD）是治疗三叉神经痛、面肌痉挛、舌咽神经痛等颅神经疾病的首选外科治疗方法。随着显微神经外科技术的进一步发展和颅神经疾病发病机制的深入研究，MVD手术应用逐步扩展到前庭蜗神经血管压迫综合征、原发性神经源性高血压、中间神经痛、痉挛性斜颈、咬肌痉挛等。本文围绕颅神经疾病的诊断和鉴别诊断、桥小脑角区划分、主要责任血管和次要责任血管、辅助技术在MVD中的应用、当下热点问题五个方面问题对中国当下MVD治疗颅神经疾病的现状与未来进行简单探讨。