切换至 "中华医学电子期刊资源库"

中华脑科疾病与康复杂志(电子版) ›› 2022, Vol. 12 ›› Issue (06) : 374 -377. doi: 10.3877/cma.j.issn.2095-123X.2022.06.011

综述

老年人认知衰弱的评估及干预的研究进展
杨申申1, 寇京莉1,(), 李耘1   
  1. 1. 100053 北京,首都医科大学宣武医院老年综合科
  • 收稿日期:2022-04-08 出版日期:2022-12-15
  • 通信作者: 寇京莉
  • 基金资助:
    2017年北京市保健科研课题(京17-2); 2021年首都医科大学宣武医院专项科研课题(HLQN-2021011)

Research progress and prospect of cognitive frailty in elderly

Shenshen Yang1, Jingli Kou1,(), Yun Li1   

  1. 1. Department of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
  • Received:2022-04-08 Published:2022-12-15
  • Corresponding author: Jingli Kou
引用本文:

杨申申, 寇京莉, 李耘. 老年人认知衰弱的评估及干预的研究进展[J]. 中华脑科疾病与康复杂志(电子版), 2022, 12(06): 374-377.

Shenshen Yang, Jingli Kou, Yun Li. Research progress and prospect of cognitive frailty in elderly[J]. Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition), 2022, 12(06): 374-377.

认知衰弱是一种老年人认知障碍的临床综合征,强调躯体衰弱和轻度认知障碍同时发生,并排除阿尔兹海默病或其他痴呆症,具有潜在可逆性。早期筛查、积极干预认知衰弱对于减少不良健康结局、提高老年人生存质量具有重要意义。本文总结老年人认知衰弱常见的筛查工具,并从运动干预、营养支持、认知疗法、不良情绪的心理调节和综合干预等5个方面概括其干预措施,以期为临床医护人员选择合适的筛查工具、进行有效的干预提供参考。

Cognitive frailty is defined as a syndrome in older adults with evidence of both physical frailty and cognitive impairment with the absence of Alzheimer's disease or any other dementias. Cognitive frailty is a potentially reversible condition. Early screening and intervention of cognitive frailty may help reduce the incidence of adverse health outcomes, improve the quality of life. This paper reviewed the assessment tools and intervention measures which include exercise interventions, nutritional support, cognitive therapy, psychological adjustment and comprehensive intervention, so as to improve medical staffs awareness towards cognitive frailty in the elderly, carry out related research and explore effective intervention.

[1]
国家统计局.第七次全国人口普查公报解读[EB/OL]. [2021-05-12].

URL    
[2]
Morley JE, Vellas B, van Kan GA, et al. Frailty consensus: a call to action[J]. J Am Med Dir Assoc, 2013, 14(6): 392-397.
[3]
王甜甜,封蔚彬,周桂娟,等.老年轻度认知障碍康复治疗研究进展[J].中国老年学杂志, 2022, 42(7): 1773-1778.
[4]
Buchman AS, Yu L, Wilson RS, et al. Brain pathology contributes to simultaneous change in physical frailty and cognition in old age[J]. J Gerontol A Biol Sci Med Sci, 2014, 69(12): 1536-1544.
[5]
Kelaiditi E, Cesari M, Canevelli M, et al. Cognitive frailty: rational and definition from an (I.A.N.A./I.A.G.G.) international consensus group[J]. J Nutr Health Aging, 2013, 17(9): 726-734.
[6]
Ruan Q, Yu Z, Chen M, et al. Cognitive frailty, a novel target for the prevention of elderly dependency[J]. Ageing Res Rev, 2015, 20: 1-10.
[7]
Wongtrakulruang P, Muangpaisan W, Panpradup B, et al. The prevalence of cognitive frailty and pre-frailty among older people in Bangkok metropolitan area: a multicenter study of hospital-based outpatient clinics[J]. J Frailty Sarcopenia Falls, 2020, 5(3): 62-71.
[8]
Fougère B, Daumas M, Lilamand M, et al. RETRACTED: association between frailty and cognitive impairment: cross-sectional data from Toulouse frailty day hospital[J]. J Am Med Dir Assoc, 2017, 18(11): 990.e991-990.e995.
[9]
王凌霄,杨永学,管丽娟,等.住院共病老年人认知衰弱现状及其影响因素[J].中华老年多器官疾病杂志, 2019, 18(10): 738-742.
[10]
刘玥婷,范俊瑶,赵慧敏,等.老年人认知衰弱对不良健康结局影响的研究进展[J].护理研究, 2020, 34(18): 3277-3282.
[11]
Canevelli M, Cesari M. Cognitive frailty: what is still missing?[J]. J Nutr Health Aging, 2015, 19(3): 273-275.
[12]
Fried LP, Tangen CM, Walston J, et al. Frailty in older adults: evidence for a phenotype[J]. J Gerontol A Biol Sci Med Sci, 2001, 56(3): M146-M156.
[13]
Lopez D, Flicker L, Dobson A. Validation of the frail scale in a cohort of older Australian women[J]. J Am Geriatr Soc, 2012, 60(1): 171-173.
[14]
Folstein MF, Folstein SE, McHugh PR. "Mini-mental state" . A practical method for grading the cognitive state of patients for the clinician[J]. J Psychiatr Res, 1975, 12(3): 189-198.
[15]
彭丹涛,许贤豪,刘江红,等.简易智能精神状态检查量表检测老年期痴呆患者的应用探讨[J].中国神经免疫学和神经病学杂志, 2005, 12(4): 187-190, 211.
[16]
Nasreddine ZS, Phillips NA, Bédirian V, et al. The Montreal cognitive assessment, MoCA: a brief screening tool for mild cognitive impairment[J]. J Am Geriatr Soc, 2005, 53(4): 695-699.
[17]
张立秀,刘雪琴.蒙特利尔认知评估量表中文版的信效度研究[J].护理研究, 2007, 21(31): 2906-2907.
[18]
Morris JC. The clinical dementia rating (CDR): current version and scoring rules[J]. Neurology, 1993, 43(11): 2412-2414.
[19]
Vlietstra L, Hendrickx W, Waters DL. Exercise interventions in healthy older adults with sarcopenia: a systematic review and meta-analysis[J]. Australas J Ageing, 2018, 37(3): 169-183.
[20]
Zhang Y, Zhang Y, Du S, et al. Exercise interventions for improving physical function, daily living activities and quality of life in community-dwelling frail older adults: a systematic review and meta-analysis of randomized controlled trials[J]. Geriatr Nurs, 2020, 41(3): 261-273.
[21]
Langlois F, Vu TT, Chassé K, et al. Benefits of physical exercise training on cognition and quality of life in frail older adults[J]. J Gerontol B Psychol Sci Soc Sci, 2013, 68(3): 400-404.
[22]
Yoon DH, Lee JY, Song W. Effects of resistance exercise training on cognitive function and physical performance in cognitive frailty: a randomized controlled trial[J]. J Nutr Health Aging, 2018, 22(8): 944-951.
[23]
Tarazona-Santabalbina FJ, Gómez-Cabrera MC, Pérez-Ros P, et al. A Multicomponent exercise intervention that reverses frailty and improves cognition, emotion, and social networking in the community-dwelling frail elderly: a randomized clinical trial[J]. J Am Med Dir Assoc, 2016, 17(5): 426-433.
[24]
Tuena C, Pedroli E, Trimarchi PD, et al. Usability issues of clinical and research applications of virtual reality in older people: a systematic review[J]. Front Hum Neurosci, 2020, 14: 93.
[25]
Zhu S, Sui Y, Shen Y, et al. Effects of virtual reality intervention on cognition and motor function in older adults with mild cognitive impairment or dementia: a systematic review and meta-analysis[J]. Front Aging Neurosci, 2021, 13: 586999.
[26]
Chye L, Wei K, Nyunt MSZ, et al. Strong relationship between malnutrition and cognitive frailty in the Singapore longitudinal ageing studies (SLAS-1 and SLAS-2)[J]. J Prev Alzheimers Dis, 2018, 5(2): 142-148.
[27]
Mantzorou M, Vadikolias K, Pavlidou E, et al. Nutritional status is associated with the degree of cognitive impairment and depressive symptoms in a Greek elderly population[J]. Nutr Neurosci, 2020, 23(3): 201-209.
[28]
Wu L, Sun D. Adherence to Mediterranean diet and risk of developing cognitive disorders: an updated systematic review and meta-analysis of prospective cohort studies[J]. Sci Rep, 2017, 7: 41317.
[29]
Kim CO, Lee KR. Preventive effect of protein-energy supplementation on the functional decline of frail older adults with low socioeconomic status: a community-based randomized controlled study[J]. J Gerontol A Biol Sci Med Sci, 2013, 68(3): 309-316.
[30]
Buigues C, Fernández-Garrido J, Pruimboom L, et al. Effect of a prebiotic formulation on frailty syndrome: a randomized, double-blind clinical trial[J]. Int J Mol Sci, 2016, 17(6): 932.
[31]
Li MM, Yu JT, Wang HF, et al. Efficacy of vitamins B supplementation on mild cognitive impairment and alzheimer's disease: a systematic review and meta-analysis[J]. Curr Alzheimer Res, 2014, 11(9): 844-852.
[32]
叶明,李书国.口服营养补充肠内营养混悬液对认知衰弱患者的影响[J].中华老年心脑血管病杂志, 2019, 21(4): 349-352.
[33]
认知训练中国专家共识写作组,中国医师协会神经内科医师分会认知障碍疾病专业委员会.认知训练中国专家共识[J].中华医学杂志, 2019, 99(1): 4-8.
[34]
北京护理学会神经内科专业委员会,中华护理学会内科专业委员会,国家老年疾病临床医学研究中心/首都医科大学宣武医院.认知训练护理门诊构建的专家共识[J].中华护理杂志, 2019, 54(10): 1504-1508.
[35]
Iizuka A, Suzuki H, Ogawa S, et al. Randomized controlled trial of the picture book reading program on cognitive function in middle-aged people[J]. Front Psychiatry, 2021, 12: 624487.
[36]
樊萍,李慧娟,李莉莉,等.脑卒中后认知障碍护理门诊的建立及实践[J].中华护理杂志, 2018, 53(11): 1352-1355.
[37]
Irazoki E, Contreras-Somoza LM, Toribio-Guzmán JM, et al. Technologies for cognitive training and cognitive rehabilitation for people with mild cognitive impairment and dementia. A systematic review[J]. Front Psychol, 2020, 11: 648.
[38]
白治繁,宋明芳,沈军.怀旧联合认知行为干预对养老机构老年人认知衰弱的效果研究[J].护理管理杂志, 2022, 22(3): 210-214.
[39]
Zou C, Yu Q, Wang C, et al. Association of depression with cognitive frailty: a systematic review and meta-analysis[J]. J Affect Disord, 2023, 320: 133-139.
[40]
Li CL, Chang HY, Stanaway FF. Combined effects of frailty status and cognitive impairment on health-related quality of life among community dwelling older adults[J]. Arch Gerontol Geriatr, 2020, 87: 103999.
[41]
Hou P, Xue H, Zhang Y, et al. Mediating effect of loneliness in the relationship between depressive symptoms and cognitive frailty in community-dwelling older adults[J]. Brain Sci, 2022, 12(10): 1341.
[42]
Romera-Liebana L, Orfila F, Segura JM, et al. Effects of a primary care-based multifactorial intervention on physical and cognitive function in frail, elderly individuals: a randomized controlled trial[J]. J Gerontol A Biol Sci Med Sci, 2018, 73(12): 1674-1688.
[43]
Yu R, Leung G, Woo J. Randomized controlled trial on the effects of a combined intervention of computerized cognitive training preceded by physical exercise for improving frailty status and cognitive function in older adults[J]. Int J Environ Res Public Health, 2021, 18(4): 1396.
[1] 李凤仪, 李若凡, 高旭, 张超凡. 目标导向液体干预对老年胃肠道肿瘤患者术后血流动力学、胃肠功能恢复的影响[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 29-32.
[2] 晏晴艳, 雍晓梅, 罗洪, 杜敏. 成都地区老年转移性乳腺癌的预后及生存因素研究[J]. 中华普外科手术学杂志(电子版), 2023, 17(06): 636-638.
[3] 李婷婷, 吴荷玉, 张悦, 程康, 张晓芳, 程娅婵. 复合保温策略在老年腹腔镜解剖性肝切除术中的应用研究[J]. 中华普外科手术学杂志(电子版), 2023, 17(05): 522-525.
[4] 刘跃刚, 薛振峰. 腹腔镜腹股沟疝日间手术在老年患者中的安全性分析[J]. 中华疝和腹壁外科杂志(电子版), 2023, 17(06): 711-714.
[5] 代格格, 杨丽, 胡媛媛, 周文婷. 手术室综合干预在老年腹股沟疝患者中的应用效果[J]. 中华疝和腹壁外科杂志(电子版), 2023, 17(06): 759-763.
[6] 赵宏霞, 刘静, 李晓薇, 陈金婵, 汪志霞. 腹腔镜下经阴道子宫全切术联合阴道前后壁修补术治疗老年子宫脱垂效果[J]. 中华疝和腹壁外科杂志(电子版), 2023, 17(05): 561-565.
[7] 孙伟, 林丽, 师高洋. 超声引导下连续髂腹股沟-髂腹下神经阻滞与腹横肌平面阻滞在老年腹股沟疝手术中应用效果比较[J]. 中华疝和腹壁外科杂志(电子版), 2023, 17(05): 593-597.
[8] 张汪, 徐淑英, 张爱华, 夏芬荣, 汪露. 手术室体温护理结合细节护理干预在老年腹股沟疝围手术期的应用效果[J]. 中华疝和腹壁外科杂志(电子版), 2023, 17(05): 635-638.
[9] 张宁, 张梦菲, 邱建新, 高闫尧, 陈育, 高靖榆. 腹腔镜下经尿道等离子电切术联合疝环充填式无张力疝修补术治疗腹股沟斜疝合并前列腺良性增生[J]. 中华疝和腹壁外科杂志(电子版), 2023, 17(04): 441-444.
[10] 杨鹏, 刘冲. PFNA治疗老年股骨转子间骨折后隐匿性失血及其危险因素的横断面研究[J]. 中华老年骨科与康复电子杂志, 2023, 09(05): 301-306.
[11] 单秋洁, 孙立柱, 徐宜全, 王之霞, 徐妍, 马浩, 刘田田. 中老年食管癌患者调强放射治疗期间放射性肺损伤风险模型构建及应用[J]. 中华消化病与影像杂志(电子版), 2023, 13(06): 388-393.
[12] 姜里蛟, 张峰, 周玉萍. 多学科诊疗模式救治老年急性非静脉曲张性上消化道大出血患者的临床观察[J]. 中华消化病与影像杂志(电子版), 2023, 13(06): 520-524.
[13] 毛树文, 袁方, 唐昊, 王建民. 针刀调节交感神经对老年胃溃疡患者胃功能和溃疡愈合的影响[J]. 中华消化病与影像杂志(电子版), 2023, 13(05): 326-330.
[14] 郭震天, 张宗明, 赵月, 刘立民, 张翀, 刘卓, 齐晖, 田坤. 机器学习算法预测老年急性胆囊炎术后住院时间探索[J]. 中华临床医师杂志(电子版), 2023, 17(9): 955-961.
[15] 晏美娟, 邵礼晖. 高水平脂蛋白(a)与无“三高”老年人群小动脉硬化型脑小血管病的相关性研究[J]. 中华脑血管病杂志(电子版), 2023, 17(05): 458-463.
阅读次数
全文


摘要