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中华脑科疾病与康复杂志(电子版) ›› 2024, Vol. 14 ›› Issue (04) : 230 -234. doi: 10.3877/cma.j.issn.2095-123X.2024.04.007

综述

骨髓间充质干细胞改善神经病理性疼痛的机制探讨
汪鹏飞1, 程莹莹2, 赵海康2,()   
  1. 1.710021 西安,西安医学院第二临床医学院麻醉系
    2.710038 西安,西安医学院第二附属医院神经外科
  • 收稿日期:2023-10-13 出版日期:2024-08-15
  • 通信作者: 赵海康
  • 基金资助:
    西安医学院科技创新团队(2021TD17)国家级大学生创新创业训练计划项目(202211840018)

Mechanism of bone marrow mesenchymal stem cells in improving neuropathic pain

Pengfei Wang1, Yingying Cheng2, Haikang Zhao2,()   

  1. 1.Department of Anesthesiology, The Second Clinical Medical College of Xi ' an Medical University, Xi ' an 710021, China
    2.Department of Neurosurgery, The Second Affiliated Hospital of Xi'an Medical University, Xi'an 710038, China
  • Received:2023-10-13 Published:2024-08-15
  • Corresponding author: Haikang Zhao
引用本文:

汪鹏飞, 程莹莹, 赵海康. 骨髓间充质干细胞改善神经病理性疼痛的机制探讨[J]. 中华脑科疾病与康复杂志(电子版), 2024, 14(04): 230-234.

Pengfei Wang, Yingying Cheng, Haikang Zhao. Mechanism of bone marrow mesenchymal stem cells in improving neuropathic pain[J]. Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition), 2024, 14(04): 230-234.

神经病理性疼痛(NP)是一种常见的慢性疼痛,严重威胁着患者的身心健康,目前尚无有效疗法。骨髓间充质干细胞(BMSCs)可通过抑制炎症及免疫调节、神经保护、抑制胶质细胞活化等途径缓解NP,但具体机制尚不清楚。本文主要通过探讨BMSCs 对NP 的作用机制,以期为NP的预防和治疗提供新思路。

Neuropathic pain (NP) is a common chronic pain that seriously threatens the physical and mental health of patients,and there is currently no effective therapy.Bone marrow mesenchymal stem cells (BMSCs) can alleviate NP by inhibiting inflammation, immune regulation, neuroprotection, and suppressing glial cell activation, but the specific mechanism is still unclear.This article mainly explores the mechanism of BMSCs on NP,in order to provide new ideas for the prevention and treatment of NP.

图1 BMSCs改善NP的作用机制 NP:神经病理性疼痛;BMSCs:骨髓间充质干细胞;GDNF:胶质源性神经营养因子;VEGF:血管内皮生长因子;FGF1:成纤维细胞生长因子1;TNF-α:肿瘤坏死因子-α;:白细胞介素-1β;NMDA:N-甲基-D-天冬氨酸;NMDAR:NMDA受体
Fig.1 Mechanism of BMSCs improving NP
[23]
Rees TA, Tasma Z, Garelja ML, et al.Calcitonin receptor,calcitonin gene-related peptide and amylin distribution in C1/2 dorsal root ganglia[J].J Headache Pain, 2024, 25(1): 36.DOI:10.1186/s10194-024-01744-z.
[24]
Lu R,Cui SS,Wang XX,et al.Astrocytic c-Jun N-terminal kinasehistone deacetylase-2 cascade contributes to glutamate transporter-1 decrease and mechanical allodynia following peripheral nerve injury in rats[J].Brain Res Bull, 2021, 175: 213-223.DOI: 10.1016/j.brainresbull.2021.07.024.
[25]
Li T, Gao Y, He M, et al.P2X7 receptor-activated microglia in cortex is critical for sleep disorder under neuropathic pain[J].Front Neurosci, 2023, 17: 1095718.DOI: 10.3389/fnins.2023.1095718.
[26]
Huang LY, Sun X, Pan HX, et al.Cell transplantation therapies for spinal cord injury focusing on bone marrow mesenchymal stem cells: advances and challenges[J].World J Stem Cells, 2023, 15(5):385-399.DOI:10.4252/wjsc.v15.i5.385.
[27]
Karavis MY, Siafaka I, Vadalouca A, et al.Role of microglia in neuropathic pain[J].Cureus, 2023, 15(8): e43555.DOI: 10.7759/cureus.43555.
[28]
Semita IN, Utomo DN, Suroto H, et al.The mechanism of human neural stem cell secretomes improves neuropathic pain and locomotor function in spinal cord injury rat models: through antioxidant, anti - inflammatory, anti - matrix degradation, and neurotrophic activities[J].Korean J Pain,2023,36(1):72-83.DOI:10.3344/kjp.22279.
[29]
崔大勇,王新,张博.小胶质细胞在颅脑损伤中免疫调控及对神经元的作用机制[J].中华神经创伤外科电子杂志, 2022, 8(1):56-58.DOI:10.3877/cma.j.issn.2095-9141.2022.01.012.Cui DY, Wang X, Zhang B.Immunoregulation of microglia in traumatic brain injury and the mechanism of action on neurons[J].Chin J Neurotrauma Surg (Electronic Edition), 2022, 8(1): 56-58.DOI:10.3877/cma.j.issn.2095-9141.2022.01.012.
[30]
Zeng C, Wang S, Gu H, et al.Galangin mitigates glucocorticoidinduced osteoporosis by activating autophagy of BMSCs via triggering the PKA/CREB signaling pathway[J].Acta Biochim Biophys Sin (Shanghai), 2023, 55(8): 1275-1287.DOI: 10.3724/abbs.2023063.
[31]
Ruan Y,Jin X,Ji H,et al.Water extract of notopterygium incisum alleviates cold allodynia in neuropathic pain by regulation of TRPA1[J].J Ethnopharmacol,2023,305:116065.DOI:10.1016/j.jep.2022.116065.
[32]
Yang H, Wu L, Deng H, et al.Anti-inflammatory protein TSG-6 secreted by bone marrow mesenchymal stem cells attenuates neuropathic pain by inhibiting the TLR2/MyD88/NF-κB signaling pathway in spinal microglia[J].J Neuroinflammation, 2020, 17(1):154.DOI:10.1186/s12974-020-1731-x.
[33]
Zhu LP, Xu ML, Yuan BT, et al.Chemokine cCCL7 mediates trigeminal neuropathic pain via CCR2/CCR3-ERK pathway in the trigeminal ganglion of mice[J].Mol Pain, 2023, 19: 1744806923 1169373.DOI:10.1177/17448069231169373.
[34]
Korczeniewska OA, Tatineni K, Faheem S, et al.Effects of intranasal melanocortin-4 receptor antagonist on trigeminal neuropathic pain in male and female rats[J].Neurosci Lett,2023,796:137054.DOI:10.1016/j.neulet.2023.137054.
[35]
Sophocleous RA, Sluyter R.From dolphins to dogs: New opportunities to understand the role of P2X4 receptors in spinal cord injury and neuropathic pain[J].Neural Regen Res, 2023, 18(7):1497-1498.DOI:10.4103/1673-5374.360294.
[36]
Jezierska - Wozniak K, Sinderewicz E, Czelejewska W, et al.Influence of bone marrow-derived mesenchymal stem cell therapy on oxidative stress intensity in minimally conscious state patients[J].J Clin Med,2020,9(3):683.DOI:10.3390/jcm9030683.
[37]
Park J, Kim YT.Erythronium japonicum alleviates inflammatory pain by inhibiting MAPK activation and by suppressing NF-κB Activation via ERK/Nrf2/HO-1 signaling pathway[J].Antioxidants(Basel),2020,9(7):626.DOI:10.3390/antiox9070626.
[38]
Proskurnina EV,Sokolova SV,Ershova ES,et al.Aantioxidant status of blood plasma of acutely psychotic patients and its correlation with Nrf2 activation[J].Zh Nevrol Psikhiatr Im S S Korsakova,2021, 121(2):60-66.DOI:10.17116/jnevro202112102160.
[39]
潘桢婕,李攀阳,李磊,等.抑制Nav1.6表达对奥沙利铂诱导的大鼠神经病理性疼痛的影响[J].郑州大学学报(医学版),2023,58(3):315-320.DOI:10.13705/j.issn.1671-6825.2022.05.061.Pan ZJ, Li PY, Li L, et al.Effects of Nav1.6 knockdown on neuropathic pain induced by oxaliplatin[J].Journal of Zhengzhou University (Medical Sciences), 2023, 58(3): 315-320.DOI: 10.13705/j.issn.1671-6825.2022.05.061.
[40]
Wang L, Cai Y, Zhang Q, et al.Pharmaceutical activation of Nrf2 accelerates diabetic wound healing by exosomes from bone marrow mesenchymal stem cells[J].Int J Stem Cells, 2022, 15(2):164-172.DOI:10.15283/ijsc21067.
[41]
Fei D, Wang Y, Zhai Q, et al.KAT6A regulates stemness of aging bone marrow-derived mesenchymal stem cells through Nrf2/ARE signaling pathway[J].Stem Cell Res Ther, 2021, 12(1): 104.DOI:10.1186/s13287-021-02164-5.
[42]
Du XJ, Chen YX, Zheng ZC, et al.Neural stem cell transplantation inhibits glial cell proliferation and P2X receptormediated neuropathic pain in spinal cord injury rats[J].Neural Regen Res, 2019, 14(5): 876-885.DOI: 10.4103/1673-5374.249236.
[43]
Meroney M,Winegar J,Brown H,et al.Modulatory effects of stem cells on opioid receptors and neuroinflammation[J].Curr Pain Headache Rep,2022,26(2):121-127.DOI:10.1007/s11916-022-01013-1.
[44]
Zhang Y,Feng J,Ou C,et al.AQP4 mitigates chronic neuropathic pain-induced cognitive impairment in mice[J].Behav Brain Res,2023,440:114282.DOI:10.1016/j.bbr.2022.114282.
[45]
Luo LL, Wang JW, Yin XL, et al.Astrocytic connexin 43 deletion ameliorates SNI-induced neuropathic pain by reducing microglia activation[J].Biochem Biophys Res Commun, 2023, 638: 192-199.DOI:10.1016/j.bbrc.2022.11.071.
[46]
Rich K, Rehman S, Jerman J, et al.Investigating the potential of GalR2 as a drug target for neuropathic pain[J].Neuropeptides,2023,98:102311.DOI:10.1016/j.npep.2022.102311.
[1]
Michaelides A, Zis P.Depression, anxiety and acute pain: links and management challenges[J].Postgrad Med, 2019, 131(7): 438-444.DOI:10.1080/00325481.2019.1663705.
[2]
朱青, 陈龙菊.神经病理性疼痛的周围和中枢机制研究进展[J].湖北民族大学学报(医学版), 2023, 40(1): 81-85.DOI:10.13501/j.cnki.42-1590/r.2023.01.015.Zhu Q, Chen LJ.Research progress on peripheral and central mechanisms of neuropathic pain[J].Journal of Hubei University(Medical Edition), 2023, 40(1): 81-85.DOI: 10.13501/j.cnki.42-1590/r.2023.01.015.
[3]
Nam JY, Chun S, Lee TY, et al.Long-term survival benefits of intrathecal autologous bone marrow-derived mesenchymal stem cells(neuronata-R®:lenzumestrocel)treatment in ALS:propensityscore-matched control,surveillance study[J].Front Aging Neurosci,2023,15:1148444.DOI:10.3389/fnagi.2023.1148444.
[4]
Fukushi R, Sasaki M, Yamashita T, et al.Investigation of the therapeutic efficacy of bone marrow mesenchymal stem cells for neuropathic pain[J].Brain and Spine, 2023, 3(Suppl 2): 102427.DOI:10.1016/j.bas.2023.102427.
[5]
Blichfeldt-Eckhardt MR, Mortensen WCP, Varnum C, et al.The Danish pain research biobank (DANPAIN-biobank): a collection of blood, cerebrospinal fluid, and clinical data for the study of neuroimmune and glia-related biomarkers of chronic pain[J].Ann Transl Med,2023,11(10):343.DOI:10.21037/atm-22-5319.
[6]
Ghazisaeidi S, Muley MM, Salter MW.Neuropathic pain:mechanisms, sex differences, and potential therapies for a global problem[J].Annu Rev Pharmacol Toxicol, 2023, 63: 565-583.DOI:10.1146/annurev-pharmtox-051421-112259.
[7]
Gholami Farashah MS, Mohammadi A, Javadi M, et al.Bone marrow mesenchymal stem cells' osteogenic potential: superiority or non-superiority to other sources of mesenchymal stem cells?[J].Cell Tissue Bank, 2023, 24(3): 663-681.DOI: 10.1007/s10561-022-10066-w.
[8]
An K, Cui Y, Zhong X, et al.Immortalized bone mesenchymal stromal cells with inducible galanin expression produce controllable pain relief in neuropathic rats[J].Cell Transplant,2022,31:9636897221103861.DOI:10.1177/09636897221103861.
[9]
Lorusso L, Ossmann M, Orozco T, et al.On the restorative break:understanding the role of break room design on nurse engagement and satisfaction[J].Workplace Health Saf, 2023, 71(7): 329-336.DOI:10.1177/21650799231157087.
[10]
Yousefifard M, Shamseddin J, Babahajian A, et al.Efficacy of adipose derived stem cells on functional and neurological improvement following ischemic stroke: a systematic review and meta-analysis[J].BMC Neurol, 2020, 20(1): 294.DOI: 10.1186/s12883-020-01865-3.
[11]
Fujii T, Yamasaki R, Miyachi Y, et al.Painful trigeminal neuropathy associated with anti-plexin D1 antibody[J].Neurol Neuroimmunol Neuroinflamm, 2020, 7(5): e819.DOI: 10.1212/nxi.0000000000000819.
[12]
Goldberg AJ, Masci L, O ' Donnell P, et al.Autologous bone marrow derived mesenchymal stem cells are safe for the treatment of achilles tendinopathy[J].Sci Rep, 2024, 14(1): 11421.DOI:10.1038/s41598-024-61399-3.
[13]
Tian J, Song T, Wang H, et al.Intrathecal injection of SIRT1-modified human mesenchymal stem cells alleviates neuropathic pain in rat[J].J Mol Neurosci, 2021, 71(5): 972-980.DOI: 10.1007/s12031-020-01717-2.
[14]
Xue H, Ran B, Li J, et al.Bone marrow mesenchymal stem cell exosomes-derived microRNA-216a-5p on locomotor performance,neuronal injury, and microglia inflammation in spinal cord injury[J].Front Cell Dev Biol, 2023, 11: 1227440.DOI: 10.3389/fcell.2023.1227440.
[15]
Dar ER, Gugjoo MB, Farooq F, et al.Mesenchymal stem cells derived from bone marrow and adipose tissue for repairing acute sciatic nerve injury in a rabbit model[J].Tissue Cell, 2023, 84:102162.DOI:10.1016/j.tice.2023.102162.
[16]
Mou C, Li Z, Liu N, et al.Low level TGF-β1-treated umbilical mesenchymal stem cells attenuates microgliosis and neuropathic pain in chronic constriction injury by exosomes/lncRNA UCA1/miR-96-5p/FOXO3a[J].Biochem Biophys Rep,2023,34:101477.DOI:10.1016/j.bbrep.2023.101477.
[17]
Zhong Z, Chen A, Fa Z, et al.Bone marrow mesenchymal stem cells upregulate PI3K/AKT pathway and down-regulate NF-κB pathway by secreting glial cell-derived neurotrophic factors to regulate microglial polarization and alleviate deafferentation pain in rats[J].Neurobiol Dis, 2020, 143: 104945.DOI: 10.1016/j.nbd.2020.104945.
[18]
Wang Q,Piao J,Li Y,et al.Bone marrow-mesenchymal stem cells alleviate microglial pyroptosis after intracerebral hemorrhage in rat by secreting C1q/tumor necrosis factor-related protein 3[J].Exp Neurol, 2023, 364: 114387.DOI: 10.1016/j.expneurol.2023.114387.
[19]
Gao X, Gao LF, Kong XQ, et al.Mesenchymal stem cell-derived extracellular vesicles carrying miR-99b-3p restrain microglial activation and neuropathic pain by stimulating autophagy[J].Int Immunopharmacol, 2023, 115: 109695.DOI: 10.1016/j.intimp.2023.109695.
[20]
Lee N, Park GT, Lim JK, et al.Mesenchymal stem cell spheroids alleviate neuropathic pain by modulating chronic inflammatory response genes[J].Front Immunol, 2022, 13: 940258.DOI:10.3389/fimmu.2022.940258.
[21]
Xing J, Wang Η, Chen L, et al.Blocking Cx43 alleviates neuropathic pain in rats with chronic constriction injury via the P2X4 and P38/ERK - P65 pathways[J].Int Immunopharmacol,2023,114:109506.DOI:10.1016/j.intimp.2022.109506.
[22]
Wang Q, He H, Xie S, et al.Mesenchymal stem cells transplantation for neuropathic pain induced by peripheral nerve injury in animal models: a systematic review[J].Stem Cells Dev,2020,29(22):1420-1428.DOI:10.1089/scd.2020.0131.
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