Research progress of bone marrow mesenchymal stem cell in the treatment of Alzheimer′s disease

doi:10.3877/cma.j.issn.2095-123X.2017.02.010

Abstract

Abstract:

Bone marrow mesenchymal stem cells (BMSCs) is a kind of stem cells that have multiple differentiation potential. Through induced BMSCs can differentiate into neural cells. Animal experiments proved that BMSCs transplantation for treatment of Alzheimer′s disease (AD) can reduce the β amyloid deposition, the level of tau protein phosphorylation, and reverse the AD pathological changes. Through the modification of BMSCs for treatment, the effect is better, and its possible mechanisms are stimulating neurogenesis and the formation of synapses, secreting various neurotrophic factors and cytokines for nerve protection, playing the role of immune regulation. This article reviews on the research progress of BMSCs in the treatment of Alzheimer′s disease.

Key words: Bone marrow mesenchymal stem cells, Alzheimer′s disease, Transplant

Hui Wang, Jing Shi, Hetao Bian, Zhongrui Yan. Research progress of bone marrow mesenchymal stem cell in the treatment of Alzheimer′s disease[J]. Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition), 2017, 07(02): 90-93.

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