Advances in research on multiple neuroactivities of vitamin D and treatment of depression

doi:10.3877/cma.j.issn.2095-123X.2019.01.011

Abstract

Abstract:

Depression is widespread worldwide, leading to increased mortality and a decline in quality of life. There is growing evidence that depression may be associated with vitamin D deficiency. As a simpler and more acceptable pharmacological intervention, vitamin D may regulate nerve activity through vitamin D receptor, maintain the Ca²⁺ balance of nerve cells, reduce the expression of inflammatory factors, and maintain the normal function of mitochondria. It also participates in the synthesis of serotonin and the regulation of reactive oxygen homeostasis to prevent and alleviate depression. This article reviews the possible mechanism of vitamin D in improving depression and the relationship between vitamin D deficiency and depression.

Key words: Vitamin D, Depression, Inflammation, Reactive oxygen homeostasis

Dan Chen, Yujin Guo, Chunmei Geng, Pei Jiang. Advances in research on multiple neuroactivities of vitamin D and treatment of depression[J]. Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition), 2019, 09(01): 48-51.

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References 45

[1]	Kessler RC. The costs of depression[J]. Psychiatr Clin North Am, 2012, 35(1): 1-14.
[2]	Druss BG, Hwang I, Petukhova M, et al. Impairment in role functioning in mental and chronic medical disorders in the United States: results from the National Comorbidity Survey Replication[J]. Mol Psychiatry, 2009, 14(7): 728-737.
[3]	WHO Guidelines Approved by the Guidelines Review Committee. mhGAP: mental health gap action programme: scaling up care for mental, neurological and substance use disorders[M]. Geneva: World Health Organization, 2008.
[4]	Soczynska JK, Mansur RB, Brietzke E, et al. Novel therapeutic targets in depression: Minocycline as a candidate treatment[J]. Behav Brain Res, 2012, 235(2): 302-317.
[5]	Narang P, Retzlaff A, Brar K, et al. Deep brain stimulation for treatment-refractory depression[J]. South Med J, 2016, 109(11): 700-703.
[6]	Anderson HD, Pace WD, Libby AM, et al. Rates of 5 common antidepressant side effects among new adult and adolescent cases of depression: a retrospective US claims study[J]. Clin Ther, 2012, 34(1): 113-123.
[7]	Eyles DW, Burne TH, McGrath JJ. Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease[J]. Front Neuroendocrinol, 2013, 34(1): 47-64.
[8]	Holick MF. Vitamin D deficiency[J]. N Engl J Med, 2007, 375(3): 266-281.
[9]	Holick MF, Maclaughlin JA, Clark MB, et al. Photosynthesis of previtamin D3 in human skin and the physiologic consequences[J]. Science, 1980, 210(4466): 203-205.
[10]	Kongsbak M, Levring TB, Geisler C, et al. The vitamin D receptor and T cell function[J]. Front Immunol, 2013, 4: 148.
[11]	Hendrix I, Anderson P, May B, et al. Regulation of gene expression by the CYP27B1 promoter-study of a transgenic mouse model[J]. J Steroid Biochem Mol Biol, 2004, 89-90(1-5): 139-142.
[12]	Puchacz E, Stumpf WE, Stachowiak EK, et al. Vitamin D increases expression of the tyrosine hydroxylase gene in adrenal medullary cells[J]. Brain Res Mol Brain Res, 1996, 36(1): 193-196.
[13]	Newell KA, Matosin N. Rethinking metabotropic glutamate receptor 5 pathological findings in psychiatric disorders: implications for the future of novel therapeutics[J]. BMC Psychiatry, 2014, 14: 23.
[14]	Berridge MJ. Vitamin D and depression: cellular and regulatory mechanisms[J]. Pharmacol Rev, 2017, 69(2): 80-92.
[15]	Wohleb ES, Gerhard D, Thomas A, et al. Molecular and cellular mechanisms of rapid-acting antidepressants ketamine and scopolamine[J]. Curr Neuropharmacol, 2017, 15(1): 11-20.
[16]	Wyskiel DR, Andrade R. Serotonin excites hippocampal CA1 GABAergic interneurons at the stratum radiatum-stratum lacunosum moleculare border[J]. Hippocampus, 2016, 26(9): 1107-1114.
[17]	Schlecker C, Boehmerle W, Jeromin A, et al. Neuronal calcium sensor-1 enhancement of InsP3 receptor activity is inhibited by therapeutic levels of lithium[J]. J Clin Invest, 2006, 116(6): 1668-1674.
[18]	Soeiro-de-Souza MG, Salvadore G, Moreno RA, et al. Bcl-2 rs956572 polymorphism is associated with increased anterior cingulate cortical glutamate in euthymic bipolar I disorder[J]. Neuropsychopharmacology, 2013, 38(3): 468-475.
[19]	Friedman AK, Juarez B, Ku SM, et al. KCNQ channel openers reverse depressive symptoms via an active resilience mechanism[J]. Nat Commun, 2016, 7: 11671.
[20]	Wasserman RH. Vitamin D and the dual processes of intestinal calcium absorption[J]. J Nutr, 2004, 134(11): 3137-3139.
[21]	Brewer LD, Thibault V, Chen KC, et al. Vitamin D hormone confers neuroprotection in parallel with downregulation of L-type calcium channel expression in hippocampal neurons[J]. J Neurosci, 2001, 21(1): 98-108.
[22]	Gezen-Ak D, Dursun E, Yilmazer S. The effects of vitamin D receptor silencing on the expression of LVSCC-A1C and LVSCC-A1D and the release of NGF in cortical neurons[J]. PLoS One, 2011, 6(3): e17553.
[23]	Zhang C, Wu Z, Zhao G, et al. Identification of IL6 as a susceptibility gene for major depressive disorder[J]. Sci Rep, 2016, 6: 31264.
[24]	Xia L, Zhang D, Wang C, et al. PC-PLC is involved in osteoclastogenesis induced by TNF-α through upregulating IP3R1 expression[J]. FEBS Lett, 2012, 586(19): 3341-3348.
[25]	Dean B, Gibbons AS, Tawadros N, et al. Different changes in cortical tumor necrosis factor-α-related pathways in schizophrenia and mood disorders[J]. Mol Psychiatry, 2013, 18(7): 767-773.
[26]	Wei R, Christakos S. Mechanisms underlying the regulation of innate and adaptive immunity by vitamin D[J]. Nutrients, 2015, 7(10): 8251-8260.
[27]	Barbosa IG, Machado-Vieira R, Soares JC, et al. The immunology of bipolar disorder[J]. Neuroimmunomodulation, 2014, 21(2-3): 117-122.
[28]	Bánsághi S, Golenár T, Madesh M, et al. Isoform- and species-specific control of inositol 1,4,5-trisphosphate (IP3) receptors by reactive oxygen species[J]. J Biol Chem, 2014, 289(12): 8170-8181.
[29]	Lock JT, Sinkins WG, Schilling WP. Effect of protein S-glutathionylation on Ca²⁺ homeostasis in cultured aortic endothelial cells[J]. Am J Physiol Heart Circ Physiol, 2011, 300(2): H493-506.
[30]	Berk M, Williams LJ, Jacka FN, et al. So depression is an inflammatory disease, but where does the inflammation come from?[J]. BMC Med, 2013, 11: 200.
[31]	Consiglio M, Viano M, Casarin S, et al. Mitochondrial and lipogenic effects of vitamin D on differentiating and proliferating human keratinocytes[J]. Exp Dermatol, 2015, 24(10): 748-753.
[32]	Silvagno F, De Vivo E, Attanasio A, et al. Mitochondrial localization of vitamin D receptor in human platelets and differentiated megakaryocytes[J]. PLoS One, 2010, 5(1): e8670.
[33]	Ryan ZC, Craig TA, Folmes CD, et al. 1α,25-dihydroxyvitamin D3 regulates mitochondrial oxygen consumption and dynamics in human skeletal muscle cells[J]. J Biol Chem, 2016, 291(3): 1514-1528.
[34]	Catena-Dell’Osso M, Bellantuono C, Consoli G, et al. Inflammatory and neurodegenerative pathways in depression: a new avenue for antidepressant development?[J]. Curr Med Chem, 2011, 18(2): 245-255.
[35]	Thompson SM, Kallarackal AJ, Kvarta MD, et al. An excitatory synapse hypothesis of depression[J]. Trends Neurosci, 2015, 38(5): 279-294.
[36]	Chabas JF, Alluin O, Rao G, et al. Vitamin D2 potentiates axon regeneration[J]. J Neurotrauma, 2008, 25(10): 1247-1256.
[37]	Grecksch G, Rüthrich H, Höllt V, et al. Transient prenatal vitamin D deficiency is associated with changes of synaptic plasticity in the dentate gyrus in adult rats[J]. Psychoneuroendocrinology, 2009, 34(Suppl 1): S258-264.
[38]	Gezenak D, Dursun E, Yilmazer S. The effect of vitamin D treatment on nerve growth factor (NGF) release from hippocampal neurons[J]. Noro Psikiyatri Arsivi, 2014, 51(2): 157-162.
[39]	Björkhem-Bergman L, Bergman P. Vitamin D and patients with palliative cancer[J]. BMJ Support Palliat Care, 2016, 6(3): 287-291.
[40]	Jääskeläinen T, Knekt P, Suvisaari J, et al. Higher serum 25-hydroxyvitamin D concentrations are related to a reduced risk of depression[J]. Br J Nutr, 2015, 113(9): 1418-1426.
[41]	de Koning EJ, van Schoor NM, Penninx BW, et al. Vitamin D supplementation to prevent depression and poor physical function in older adults: study protocol of the D-Vitaal study, a randomized placebo-controlled clinical trial[J]. BMC Geriatr, 2015, 15: 151.
[42]	Gowda U, Mutowo MP, Smith BJ, et al. Vitamin D supplementation to reduce depression in adults: Meta-analysis of randomized controlled trials[J]. Nutrition, 2015, 31(3): 421-429.
[43]	Bahrami A, Mazloum SR, Maghsoudi S, et al. High Dose vitamin D supplementation is associated with a reduction in depression score among adolescent girls: a nine-week follow-up study[J]. J Diet Suppl, 2018, 15(2): 173-182.
[44]	Shaffer JA, Edmondson D, Wasson LT, et al. Vitamin D supplementation for depressive symptoms: a systematic review and meta-analysis of randomized controlled trials[J]. Psychosom Med, 2014, 76(3): 190-196.
[45]	Li G, Mbuagbaw L, Samaan Z, et al. Efficacy of vitamin D supplementation in depression in adults: a systematic review[J]. J Clin Endocrinol Metab, 2014, 99(3): 757-767.

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