Relationship between serum factor, pulmonary function and obstructive sleep apnea syndrome in patients with acute ischemic stroke

doi:10.3877/cma.j.issn.2095-123X.2019.03.003

Abstract

Abstract:

Objective

To discuss the changes of serum uric acid (UA), triglyseride (TG) and low density lipoprotein cholesterol (LDL-C) levels and lung function in patients with acute ischemic stroke (AIS) and their relationship with obstructive sleep apnea syndrome (OSAS).

Methods

Fifty patients with AIS were selected from March 2015 to March 2018 in our hospital as AIS group. In the same period, 50 patients with AIS combined with OSAS were selected as AIS-OSAS group, and 50 healthy persons were selected as the health group. The UA, blood lipid [cholesterol (TC), TG, LDL-C, high density lipoprotein cholesterol (HDL-C)], lung function [1 s forced expiratory volume (FEV1), forced vital capacity (FVC), FEV1/FVC] were compared among the three groups, and the relationship between UA, TG, LDL-C, lung function and AS was analyzed.

Results

In UA, TG, LDL-C, AIS-OSAS group was significantly higher than AIS group, AIS group was significantly higher than healthy group, the difference was statistically significant (P<0.05). TC and HDL-C in three groups had no significant difference (P>0.05). In FEV1, FVC, FEV1/FVC, AIS-OSAS group was significantly lower than AIS group, AIS group was significantly lower than that of healthy group, the difference was statistically significant (P<0.05). Pearson correlation analysis showed that UA, TG and LDL-C were negatively correlated with FEV1/FVC (P<0.05). Logistic regression analysis showed that the increase of UA, TG and LDL-C was the independent influence factor of AIS combined with OSAS (P<0.05).

Conclusion

AIS patients had abnormal UA, TG, LDL-C and pulmonary function inhibition. The three groups were related to changes in lung function, and it is also an independent factor in the combination of AIS and OSAS.

Key words: Acute ischemic stroke, Blood uric acid, Triglyceride, Low density lipoprotein cholesterol, Lung function, Obstructive sleep apnea syndrome

Zhongmei Ren, Anxin Zhang, Chunli Xing. Relationship between serum factor, pulmonary function and obstructive sleep apnea syndrome in patients with acute ischemic stroke[J]. Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition), 2019, 09(03): 137-141.

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References 20

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组别	例数	性别（男/女）	年龄（岁）	BMI（kg/m²）	糖尿病	高血压	病灶数	最大病灶直径（cm）	病程（h）	严重程度（轻/中/重）
AIS组	50	29/21	59.80±8.58	23.62±2.05	23	24	0.36±0.23	2.32±0.52	6.47±0.71	16/22/12
AIS-OSAS组	50	28/22	59.82±8.61	23.57±2.04	25	26	0.35±0.25	2.33±0.48	6.50±0.73	17/20/13
健康组	50	27/23	59.89±8.60	23.58±2.06	-	-	-	-	-	-
χ²/Z/t值	?	0.462	0.911	0.225	0.160	0.160	0.208	0.100	0.208	0.245
P值	?	0.993	1.030	1.436	0.689	0.689	0.836	0.921	0.836	0.806

组别	例数	性别（男/女）	年龄（岁）	BMI（kg/m²）	糖尿病	高血压	病灶数	最大病灶直径（cm）	病程（h）	严重程度（轻/中/重）
AIS组	50	29/21	59.80±8.58	23.62±2.05	23	24	0.36±0.23	2.32±0.52	6.47±0.71	16/22/12
AIS-OSAS组	50	28/22	59.82±8.61	23.57±2.04	25	26	0.35±0.25	2.33±0.48	6.50±0.73	17/20/13
健康组	50	27/23	59.89±8.60	23.58±2.06	-	-	-	-	-	-
χ²/Z/t值	?	0.462	0.911	0.225	0.160	0.160	0.208	0.100	0.208	0.245
P值	?	0.993	1.030	1.436	0.689	0.689	0.836	0.921	0.836	0.806

组别	例数	UA	TG	LDL-C	TC	HDL-C
AIS-OSAS组	50	4.63±0.41	4.11±0.42	4.21±0.65	3.21±0.45	1.12±0.21
AIS组	50	3.53±0.38^a	2.66±0.38^a	2.58±0.34^a	3.25±0.54	1.15±0.19
健康组	50	2.87±0.71^ab	1.83±0.16^ab	1.67±0.45^ab	3.24±0.49	1.16±0.20
F值	?	12.421	15.621	15.271	0.204	0.324
P值	?	<0.001	<0.001	<0.001	1.460	1.341

组别	例数	UA	TG	LDL-C	TC	HDL-C
AIS-OSAS组	50	4.63±0.41	4.11±0.42	4.21±0.65	3.21±0.45	1.12±0.21
AIS组	50	3.53±0.38^a	2.66±0.38^a	2.58±0.34^a	3.25±0.54	1.15±0.19
健康组	50	2.87±0.71^ab	1.83±0.16^ab	1.67±0.45^ab	3.24±0.49	1.16±0.20
F值	?	12.421	15.621	15.271	0.204	0.324
P值	?	<0.001	<0.001	<0.001	1.460	1.341

组别	例数	FEV1	FVC	FEV1/FVC
AIS-OSAS组	50	2.75±0.35	1.94±0.33	46.32±5.28
AIS组	50	3.34±0.43^a	2.53±0.27^a	56.28±6.67^a
健康组	50	4.01±0.51^ab	3.12±0.42^ab	62.01±7.66^ab
F值	?	13.271	12.472	16.721
P值	?	<0.001	<0.001	<0.001

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