Clinical significance of serum vitamin D levels in children bacterial meningitis

doi:10.3877/cma.j.issn.2095-123X.2019.05.008

Abstract

Abstract:

Objective

To investigate the level of serum vitamin D in the course of bacterial meningitis in children and its clinical relationship with children.

Methods

Forty-three cases of children with bacterial meningitis admitted to pediatrics department of Lianjiang People’s Hospital from January 2018 to September 2019 were selected as study subjects. The serum vitamin D levels of the children were detected by liquid chromatography-tandem mass spectrometry on day 1, 14 and 28, and the change characteristics of serum vitamin D levels were analyzed. Children were divided into observation group and control group according to the change characteristics of serum vitamin D level, and then the difference of GCS score, pediatric critical illness score (PCIS), cerebrospinal fluid (CSF) biochemistry (WBC, protein, glucose) between the two groups was compared on day 1, 14 and 28.

Results

Twenty-nine cases showed a continuous decrease in serum vitamin D level, serving as the observation group. Fourteen cases serum vitamin D level showed irregular or continued to increase, serving as the control group. There was a significant difference in vitamin D levels between the observation group and the control group (P<0.05). There was no significant difference in GCS score and PCIS score between the observation group and the control group on the first day (P>0.05), but it was smaller than that of the control group on day 14 and 28 (P<0.05). There was no significant difference between the observation group and the control group in the number of CSF white blood cells on the first day (P>0.05), but it was higher than the control group on day 14 and 28, with statistical difference (P<0.05). There was no significant difference in CSF protein between the observation group and the control group on day 1 and 14 (P>0.05), but it was higher than the control group on day 28 (P<0.05). There was no significant difference in CSF glucose between the observation group and the control group on day 1(P>0.05), but it was lower than that of the control group on day 14 and 28 (P<0.05). The number of complications and surgical treatment cases in the observation group was lower than that in the control group, and the difference was statistically significant (P<0.05).

Conclusion

Some children with bacterial meningitis may have an abnormal decrease in serum vitamin D level, which is more likely to cause complications in clinical treatment than normal children with serum vitamin D level, and the probability of requiring surgical treatment is higher, and the recovery of children is slower, which should be paid attention to.

Key words: Bacterial meningitis in children, Vitamin D, Rehabilitation

Tao Lin, Hong Ye, Dongying Jie. Clinical significance of serum vitamin D levels in children bacterial meningitis[J]. Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition), 2019, 09(05): 289-292.

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References 21

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项目		观察组（n=29）	对照组（n=14）	t/χ²值	P值
性别（男/女）		17/12	6/8	0.943	0.331
年龄（岁）		8.41±3.43	9.14±2.83	0.690	0.494
GCS评分		?	?	?	?
?	第1天	8.48±1.38	8.64±1.69	0.331	0.742
?	第14天	8.79±1.32	9.79±1.25	2.349	0.024
?	第28天	9.03±1.40	10.29±1.14	2.905	0.006
PCIS评分		?	?	?	?
?	第1天	79.03±4.33	78.43±4.65	0.420	0.677
?	第14天	79.93±3.48	82.29±3.58	2.058	0.046
?	第28天	80.07±3.68	83.29±2.67	2.911	0.006
脑脊液白细胞（/mm³）		?	?	?	?
?	第1天	161.76±43.68	166.57±56.53	0.307	0.760
?	第14天	82.59±29.96	62.86±25.85	2.111	0.041
?	第28天	61.52±25.53	43.57±16.40	2.394	0.021
脑脊液蛋白（mg/dL）		?	?	?	?
?	第1天	195.34±71.39	212.64±58.76	0.786	0.437
?	第14天	102.34±41.71	97.57±48.05	0.335	0.740
?	第28天	68.45±19.65	52.71±21.57	2.384	0.022
脑脊液葡萄糖（mg/dL）		?	?	?	?
?	第1天	27.07±6.86	24.71±6.63	1.067	0.292
?	第14天	36.34±11.50	48.07±18.20	2.207	0.040
?	第28天	42.41±14.01	56.93±16.40	3.011	0.004
并发症		17	3	5.250	0.022
手术治疗		5	1	0.802	0.645

项目		观察组（n=29）	对照组（n=14）	t/χ²值	P值
性别（男/女）		17/12	6/8	0.943	0.331
年龄（岁）		8.41±3.43	9.14±2.83	0.690	0.494
GCS评分		?	?	?	?
?	第1天	8.48±1.38	8.64±1.69	0.331	0.742
?	第14天	8.79±1.32	9.79±1.25	2.349	0.024
?	第28天	9.03±1.40	10.29±1.14	2.905	0.006
PCIS评分		?	?	?	?
?	第1天	79.03±4.33	78.43±4.65	0.420	0.677
?	第14天	79.93±3.48	82.29±3.58	2.058	0.046
?	第28天	80.07±3.68	83.29±2.67	2.911	0.006
脑脊液白细胞（/mm³）		?	?	?	?
?	第1天	161.76±43.68	166.57±56.53	0.307	0.760
?	第14天	82.59±29.96	62.86±25.85	2.111	0.041
?	第28天	61.52±25.53	43.57±16.40	2.394	0.021
脑脊液蛋白（mg/dL）		?	?	?	?
?	第1天	195.34±71.39	212.64±58.76	0.786	0.437
?	第14天	102.34±41.71	97.57±48.05	0.335	0.740
?	第28天	68.45±19.65	52.71±21.57	2.384	0.022
脑脊液葡萄糖（mg/dL）		?	?	?	?
?	第1天	27.07±6.86	24.71±6.63	1.067	0.292
?	第14天	36.34±11.50	48.07±18.20	2.207	0.040
?	第28天	42.41±14.01	56.93±16.40	3.011	0.004
并发症		17	3	5.250	0.022
手术治疗		5	1	0.802	0.645

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