To comparison of the clinical effect of dexamethasone intrathecal injection and intravenous injection for aseptic meningitis (AM) after microvascular decompression (MVD).

One hundred and thirty-eight patients with AM after MVD in Department of Neurosurgery of Shengli Oilfield Central Hospital from January 2015 to January 2020 were selected as the research objects, and they were divided into control group and observation group. Sixty-eight patients in the control group were treated with intravenous injection of dexamethasone (10 mg/time), the frequency was on-demand administration; 70 patients in the observation group were treated with lumbar puncture liquid and intrathecal injection of dexamethasone (60 μg/(kg·times), the frequency was once a day or the next day. The remission of headache and fever, postoperative hospital stay, frequency of treatment, and adverse effects of steroid were compared between the two groups.

At 8 and 72 h after treatment, the headache and fever of the two groups were remission, and the observation group was significantly better than the control group (P<0.05). The postoperative hospital stay of the observation group [(7.68±2.23) d] was significantly shorter than that of the control group [(12.76±2.37) d, P<0.05]. The frequency of treatment of the observation group (3.5±0.6) was significantly lower than that of the control group (6.8±0.9) (P<0.05). No significant adverse effects were observed in both groups.

The combination of lumbar puncture and dexamethasone intrathecal injection is significantly effective in treating AM after MVD, which can effectively improve the headache, fever and other clinical symptoms, reduce the amount of hormone, and shorten the postoperative hospital stay, and is worthy of promotion.