To analyze the characteristics and development trend of clinical trials registration for traumatic brain injury (TBI) that registered on Chinese Clinical Trials Registry (ChiCTR).

Clinical trials related to TBI on ChiCTR database were searched and included. The retrieval time was from the date of establishment of the registry to April 31, 2021. The characteristics of clinical trial registrations were analyzed.

A total of 118 TBI related registered clinical trials were included. The registered areas in Jiangsu, Shanghai, Sichuan, Beijing, Guangdong and Chongqing accounted for 69.45% of these trials. In addition, 101 trials were pre-registered before trials carry out. The funding from local finance (n=41, 34.75%), self-funded (n=29, 24.58%) and national finance (n=13, 11.02%) were the main proportion of sources. Moreover, 42 trials were lacked blinding method among the 61 randomized controlled trials.

The number of clinical trials registered in ChiCTR for TBI shows an increasing trend, but lack of regional balance. The awareness of researchers for clinical trial registration has been improved, but a part of the clinical trial registration were unstandardized and incomplete. Researchers should strength the awareness of registration, learn registration knowledge, and ensure the quality of research. Relevant departments should expand the publicity of clinical trial registration, clarify the registration specification, and ensure the authenticity of registration.