Correlation between quantitative electroencephalogram power spectrum related parameters and cognitive impairment in patients with epilepsy

doi:10.3877/cma.j.issn.2095-123X.2023.05.008

Abstract

Abstract:

Objective

To analyze the correlation between quantitative electroencephalography (QEEG) power spectrum related parameters and cognitive impairment in patients with epilepsy (EP).

Methods

A total of 130 patients with EP who were admitted to the Neurology Department at Gongan County People's Hospital from August 2019 to August 2021 were selected as the observation group. Meanwhile, 130 healthy volunteers who received health check-ups in the same hospital were selected as the control group. The clinical memory scale (CMS) scores were compared between the two groups. EP patients were divided into a cognitive impairment group [memory quotient (MQ)<90 points] and a cognitive normal group (MQ≥90 points) based on their MQ score. The percentage power values in α, θ, β and δ frequency bands of 3 groups were compared. The correlation between the percentage power value of each QEEG frequency band and CMS was analyzed.

Results

The scores for different dimensions of CMS in the observation group were significantly lower than those in the control group (P<0.05). Among EP patients, 54 patients had MQ score under 90 and they were included in the cognitive impairment group, the other 76 patients with MQ score of 90 or higher were included in the normal cognitive function group. The percentage power value of α frequency band in the cognitive impairment group was significantly lower than those in the normal cognitive function group and the control group. The percentage power values of θ and δ frequency bands were significantly higher than those in the normal cognitive function group and the control group (P<0.05). Pearson correlation analysis found that the percentage power value of QEEG α frequency band was positively correlated with MQ score (r=0.338, P<0.05). The percentage power values of θ and δ frequency bands were negatively correlated with MQ score (r=-0.695, -0.724, P<0.05).

Conclusion

There is a significant correlation between QEEG power spectrum parameters and cognitive impairment in patients with EP. These parameters may provide reference for cognitive function intervention of patients with EP.

Key words: Epilepsy, Electroencephalogram power spectrum, Cognitive function

Xingao Wu, Wei Li, Jun Ma, Hong Liu, Ping Huang. Correlation between quantitative electroencephalogram power spectrum related parameters and cognitive impairment in patients with epilepsy[J]. Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition), 2023, 13(05): 304-308.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhnkjbykfzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2095-123X.2023.05.008

https://zhnkjbykfzz.cma-cmc.com.cn/EN/Y2023/V13/I05/304

Figures/Tables 4

References 19

[1]	Pack AM. Epilepsy overview and revised classification of seizures and epilepsies[J]. Continuum (Minneap Minn), 2019, 25(2): 306-321. DOI: 10.1212/CON.0000000000000707.
[2]	Rugg-Gunn F, Miserocchi A, McEvoy A. Epilepsy surgery[J]. Pract Neurol, 2020, 20(1): 4-14. DOI: 10.1136/practneurol-2019-002192.
[3]	Feter N, Alt R, Häfele CA, et al. Effect of combined physical training on cognitive function in people with epilepsy: results from a randomized controlled trial[J]. Epilepsia, 2020, 61(8): 1649-1658. DOI: 10.1111/epi.16588.
[4]	Huang Q, Liu J, Shi Z, et al. Correlation of MMP-9 and HMGB1 expression with the cognitive function in patients with epilepsy and factors affecting the prognosis[J]. Cell Mol Biol (Noisy-le-grand), 2020, 66(3): 39-47.
[5]	张慧敏,温晓红,黄金华,等.韦氏儿童智力量表第四版在癫痫儿童认知评估中的应用[J].中国儿童保健杂志, 2018, 26(10): 1120-1123. DOI: 10.11852/zgetbjzz2018-26-10-20.
[6]	Goenka A, Boro A, Yozawitz E. Assessing quantitative EEG spectrograms to identify non-epileptic events[J]. Epileptic Disord, 2017, 19(3): 299-306. DOI: 10.1684/epd.2017.0921.
[7]	Müller M, Schindler K, Goodfellow M, et al. Evaluating resective surgery targets in epilepsy patients: a comparison of quantitative EEG methods[J]. J Neurosci Methods, 2018: 15(305): 54-56. DOI: 10.1016/j.jneumeth.2018.04.021.
[8]	中华医学会.临床诊疗指南:癫痫病分册[M].北京:人民卫生出版社, 2007: 34-38.
[9]	"临床记忆量表"编制协作组. "临床记忆量表"的编制[J].心理学报, 1986, 18(1): 100-108.
[10]	Allone C, Lo Buono V, Corallo F, et al. Neuroimaging and cognitive functions in temporal lobe epilepsy: a review of the literature[J]. J Neurol Sci, 2017, 15(10), 381: 7-15. DOI: 10.1016/j.jns.2017.08.007.
[11]	Lee SY, Park JH, Park SJ, et al. Cognitive function and neuropsychological comorbidities in children with newly diagnosed idiopathic epilepsy[J]. J Korean Med Sci, 2018, 33(3): e17. DOI: 10.3346/jkms.2018.33.e17.
[12]	陈悦,杨增泰,张丽霞,等.间期癫痫样放电对癫痫患儿认知功能影响[J].中国实验诊断学, 2021, 25(5): 673-676. DOI: 10.3969/j.issn.1007-4287.2021.05.011.
[13]	何甲林子,肖波,刘超荣,等.颞叶癫痫认知功能障碍的特点及其临床影响因素[J].中南大学学报(医学版), 2021, 46(3): 240-248. DOI: 10.11817/j.issn.1672-7347.2021.200770.
[14]	Cohen E, Wong FY, Wallace EM, et al. EEG power spectrum maturation in preterm fetal growth restricted infants[J]. Brain Res, 2017, 1678: 180-186. DOI: 10.1016/j.brainres.2017.10.010.
[15]	廖红霞,杨加亮,杨渌.脑电图监测对额叶癫痫发作性患者的早期诊断及术中辅助定位价值研究[J].影像科学与光化学, 2021, 39(1): 19-23. DOI: 10.7517/issn.1674-0475.200707.
[16]	王若凡,刘静,王江,等.基于功率谱及有限穿越可视图的癫痫脑电信号分析算法[J].计算机应用, 2017, 37(1): 175-182. DOI: 10.11772/j.issn.1001-9081.2017.01.0175.
[17]	任晓卉,刑燕,李静.首治癫痫患儿脑电图与血清α-突触核蛋白和tau蛋白表达的相关性[J].中国妇幼保健, 2021, 36(15): 3586-3589. DOI: 10.19829/j.zgfybj.issn.1001-4411.2021.15.054.
[18]	马芸,徐海清,钱展,等. MMSE正常的帕金森病患者定量脑电图与早期认知障碍的相关性[J].中国神经免疫学和神经病学杂志, 2018, 25(1): 57-61. DOI: 10.3969/j.issn.1006-2963.2018.01.014.
[19]	吴越,汤莉,范洁,等.主观认知功能障碍老年人神经心理学及脑电图特征[J].中国老年学杂志, 2019, 39(7): 1634-1637. DOI: 10.3969/j.issn.1005-9202.2019.07.035.

组别	例数	性别[例（%）]		年龄（岁，Mean±SD）	受教育年限[年，M（P₂₅，P₇₅）]
组别	例数	男	女	年龄（岁，Mean±SD）	受教育年限[年，M（P₂₅，P₇₅）]
观察组	130	71（54.62）	59（45.38）	24.17±5.09	13.50（12.00，19.00）
对照组	130	75（57.69）	55（42.31）	25.01±4.98	13.00（12.00，18.00）
χ²/t/Z值		0.250		1.345	0.620
P值		0.617		0.180	0.836

组别	例数	性别[例（%）]		年龄（岁，Mean±SD）	受教育年限[年，M（P₂₅，P₇₅）]
组别	例数	男	女	年龄（岁，Mean±SD）	受教育年限[年，M（P₂₅，P₇₅）]
观察组	130	71（54.62）	59（45.38）	24.17±5.09	13.50（12.00，19.00）
对照组	130	75（57.69）	55（42.31）	25.01±4.98	13.00（12.00，18.00）
χ²/t/Z值		0.250		1.345	0.620
P值		0.617		0.180	0.836

CMS评分	观察组（n=130）	对照组（n=130）	t值	P值
MQ	94.04±19.21	105.75±9.45	-6.219	<0.001
指向记忆	16.41±6.93	20.15±6.21	-4.578	<0.001
联想学习	23.29±9.06	26.88±5.51	-3.857	<0.001
图像自由回忆	17.84±6.92	25.76±3.78	-11.438	<0.001
无意义图形再认	17.81±4.47	20.64±2.93	-6.045	<0.001
人像特点联系回忆	18.90±6.67	22.30±5.79	-4.384	<0.001

CMS评分	观察组（n=130）	对照组（n=130）	t值	P值
MQ	94.04±19.21	105.75±9.45	-6.219	<0.001
指向记忆	16.41±6.93	20.15±6.21	-4.578	<0.001
联想学习	23.29±9.06	26.88±5.51	-3.857	<0.001
图像自由回忆	17.84±6.92	25.76±3.78	-11.438	<0.001
无意义图形再认	17.81±4.47	20.64±2.93	-6.045	<0.001
人像特点联系回忆	18.90±6.67	22.30±5.79	-4.384	<0.001

频段	对照组（n=130）	认知功能正常组（n=76）	认知功能损伤组（n=54）	F值	P值
α	60.48±11.01	61.35±11.07	50.97±10.97^ab	6.334	0.002
θ	4.01±1.97	4.02±1.07	7.54±1.55^ab	44.915	<0.001
β	17.52±3.84	17.60±4.03	15.91±3.79	0.659	0.518
δ	2.93±0.40	2.91±0.46	5.94±1.54^ab	66.333	<0.001

Please choose a citation manager

Content to export