Application of neural organs in the treatment of common brain diseases and their prospects in the repair of spinal cord injuries

doi:10.3877/cma.j.issn.2095-123X.2024.05.001

Abstract

Abstract:

Traumatic spinal cord injury is often accompanied by irreversible damage to neurons and deterioration and remodeling of the cellular microenvironment， causing long-term loss of movement，sensory dyfunction and autonomic dysfunction. Although rodent and non-human primate models have contributed significantly to modelling the pathological mechanisms of spinal cord damage and to screening treatments， animal experimental results often differ from clinical practice due to differences between species. Recent studies shown that functional neural organoids formed from pluripotent stem cells in a three-dimensional culture system contain many key features of the human brain or spinal cord.Compared with the neural stem cells/neural progenitor cells cultured in two dimensions， the neural organoids have more stable cell architecture， tissue morphology and more mature neural differentiation，and，play a significant role in the simulation of diseases such as Parkinson's disease，Alzheimer's disease，traumatic brain injury， and stroke. Meanwhile， in nerve injury repair， neural organoids have a high survival rate after transplantation， and can promote vascular regeneration in the injured area and form functional connections with the host. This review summarizes the application of neural organoids in Parkinson's disease， Alzheimer's disease， traumatic brain injury， stroke， and discusses the application value of spinal cord injury repairment.

Key words: Nueral organoids, Nerve damage, Regeneration, Differentiation

Jin Zhang, Xinda Li, Ruxiang Xu. Application of neural organs in the treatment of common brain diseases and their prospects in the repair of spinal cord injuries[J]. Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition), 2024, 14(05): 257-263.

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