Research on brain network functional connectivity of upper limb motor dysfunction patients after stroke using multi-target neuroregulation technology

doi:10.3877/cma.j.issn.2095-123X.2024.05.003

Abstract

Abstract:

Objective

To investigate the effects of multi-target neuroregulation technology on upper limb motor function recovery in stroke patients.

Methods

A total of 78 patients with upper limb motor dysfunction after stroke admitted to Rehabilitation Medicine Department of the Third Hospital of Mianyang and Mianyang Traditional Chinese Medicine Hospital from June 2021 to August 2022 were selected for this prospective study. Patients were randomly assigned to the experimental group and the control group using a random number table， with 39 patients in each group. The experimental group received high-precision transcranial direct current stimulation multi-target neuroregulation technology combined with conventional rehabilitation training， while the control group received the same rehabilitation training but with sham stimulation. The treatment period was one month. Before and after treatment，upper limb function was assessed using the Fugl-Meyer assessment upper extremity （FMA-UE），and functional near-infrared spectroscopy data were collected during the resting state.

Results

After training， significant improvements in FMA-UE scores were observed in both groups （P＜0.001）， with a significantly greater improvement in the experimental group compared to the control group （P＜0.05）.Before and after training， both groups showed increased brain network connectivity strength， with significantly greater improvement in the experimental group compared to the control group （P＜0.05）.

Conclusion

Multi-target neuroregulation technology and conventional rehabilitation training can both enhance upper limb motor function and brain network connectivity in stroke patients.However，compared to traditional rehabilitation methods， multi-target neuroregulation technology has a more significant effect on improving upper limb motor function and resting-state brain functional network connectivity.

Key words: Stroke, Upper limb motor dysfunction, Neuroregulation, Functional near-infrared spectroscopy, Resting state, Brain functional connectivity

Hong Zhang, Qi Yang, Jing Luo, Xi Tang, Hong Deng, Wenyuan Gong, Likun Wang, Jing Liu, Shuangchun Ai. Research on brain network functional connectivity of upper limb motor dysfunction patients after stroke using multi-target neuroregulation technology[J]. Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition), 2024, 14(05): 278-284.

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References 20

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组别	例数	性别（男/女）	年龄（岁，Mean±SD）	病程（d，Mean±SD）
对照组	39	27/12	58.9±6.4	16.5±6.5
试验组	39	23/16	60.8±6.3	18.1±6.8
χ ²/t值		0.501	1.321	1.062
P值		0.479	0.190	0.292

组别	例数	性别（男/女）	年龄（岁，Mean±SD）	病程（d，Mean±SD）
对照组	39	27/12	58.9±6.4	16.5±6.5
试验组	39	23/16	60.8±6.3	18.1±6.8
χ ²/t值		0.501	1.321	1.062
P值		0.479	0.190	0.292

组别	例数	治疗前	治疗4周	t值	P值
试验组	39	17.98±4.68	29.32±3.45	12.180	＜0.001
对照组	39	18.75±3.62	27.28±4.02	9.847	＜0.001
t值		0.813	2.404
P值		0.419	0.019

组别	例数	治疗前	治疗4周	t值	P值
试验组	39	17.98±4.68	29.32±3.45	12.180	＜0.001
对照组	39	18.75±3.62	27.28±4.02	9.847	＜0.001
t值		0.813	2.404
P值		0.419	0.019

组别	例数	治疗前	治疗4周	t值	P值
试验组	39	0.335±0.087	0.465±0.075	7.068	＜0.001
对照组	39	0.328±0.092	0.398±0.094	3.324	＜0.001
t值		0.345	3.479
P值		0.731	＜0.001

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