Study on the effects of dexmedetomidine in surgery for chronic subdural hematoma

doi:10.3877/cma.j.issn.2095-123X.2025.05.006

Abstract

Abstract:

Objective

To investigate the impacts of Dexmedetomidine on intraoperative hemodynamics and postoperative pain in patients with chronic subdural hematoma (CSDH) undergoing surgical treatment.

Methods

A total of 96 patients undergoing surgery for CSDH admitted to the Neurosurgery Department of Langfang Aidebao Hospital from October 2020 to October 2022 were selected as the research subjects. They were randomly separated into a control group and a study group using a random number table method, with 48 patients in each group. The control group were given simple local anesthesia, while the study group were given Dexmedetomidine combined local anesthesia. The changes of mean arterial pressure (MAP) and heart rate at the time of skin incision (T1), drilling (T2), skin suture (T3), and the end of surgery (T4), and the pain and analgesia intensity at 3, 12, 24, 48, and 72 h after surgery were compared between the two groups.

Results

The MAP and heart rate of patients in the study group were significantly higher than those in the control group at time points T1, T2, T3, and T4 (P<0.05); at 3, 12, 24, 48 and 72 h after surgery, the visual analogue scale (VAS) of the study group was lower than that of the control group (P<0.05); at 12, 24, 48, and 72 h after surgery, the Ramsay scores of patients in the study group were higher than those in the control group (P<0.05); the incidence of adverse reactions during anesthesia in the study group was lower than that in the control group (P<0.05).

Conclusions

Dexmedetomidine has a good anesthetic effect in patients undergoing surgical treatment for CSDH. It can help maintain hemodynamic stability during surgery, enhance analgesic and sedative effects, and reduce adverse reactions.

Key words: Dexmedetomidine, Chronic subdural hematoma, Surgery, Hemodynamics, Pain

Feifei Niu, Quanle Zheng, Tingting Zhang, Tongle Zhang, Xuetian Li, Wenqi Yang. Study on the effects of dexmedetomidine in surgery for chronic subdural hematoma[J]. Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition), 2025, 15(05): 288-292.

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References 19

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组别	例数	性别（男/女，例）	年龄（岁，mean±SD）	BMI（kg/m²，mean±SD）
对照组	48	21/27	45.32±9.66	23.67±2.55
研究组	48	23/25	45.94±10.12	23.91±2.36
χ²/t值		0.091	-0.307	-0.479
P值		0.763	0.760	0.633

组别	例数	性别（男/女，例）	年龄（岁，mean±SD）	BMI（kg/m²，mean±SD）
对照组	48	21/27	45.32±9.66	23.67±2.55
研究组	48	23/25	45.94±10.12	23.91±2.36
χ²/t值		0.091	-0.307	-0.479
P值		0.763	0.760	0.633

项目	组别	例数	T0	T1	T2	T3	T4	F值	P值
MAP（mmHg）	研究组	48	98.72±10.76	94.02±9.91	90.47±9.58	91.16±9.82	93.38±9.66	4.315	0.002
	对照组	48	98.29±10.82	84.53±9.07	80.22±8.62	82.41±8.57	84.16±8.62	28.880	<0.001
	t值		0.192	4.924	5.583	4.711	5.032
	P值		0.849	<0.001	<0.001	<0.001	<0.001
心率（次/min）	研究组	48	77.18±8.02	74.71±8.15	73.35±8.07	70.14±7.64	70.32±7.57	23.350	<0.001
	对照组	48	76.62±8.14	70.12±7.79	68.28±7.92	66.36±7.05	67.21±6.95	14.060	<0.001
	t值		0.342	2.921	3.244	2.492	2.124
	P值		0.734	0.004	0.002	0.015	0.037

项目	组别	例数	T0	T1	T2	T3	T4	F值	P值
MAP（mmHg）	研究组	48	98.72±10.76	94.02±9.91	90.47±9.58	91.16±9.82	93.38±9.66	4.315	0.002
	对照组	48	98.29±10.82	84.53±9.07	80.22±8.62	82.41±8.57	84.16±8.62	28.880	<0.001
	t值		0.192	4.924	5.583	4.711	5.032
	P值		0.849	<0.001	<0.001	<0.001	<0.001
心率（次/min）	研究组	48	77.18±8.02	74.71±8.15	73.35±8.07	70.14±7.64	70.32±7.57	23.350	<0.001
	对照组	48	76.62±8.14	70.12±7.79	68.28±7.92	66.36±7.05	67.21±6.95	14.060	<0.001
	t值		0.342	2.921	3.244	2.492	2.124
	P值		0.734	0.004	0.002	0.015	0.037

项目	组别	例数	术后3 h	术后12 h	术后24 h	术后48 h	术后72 h
VAS评分	研究组	48	3.19±0.52	3.66±0.47	4.14±0.61	4.75±0.77	3.47±0.61
	对照组	48	4.01±0.86	4.97±0.92	5.45±0.98	6.16±1.04	5.46±0.84
	t值		5.621	8.642	7.824	7.512	13.281
	P值		<0.001	<0.001	<0.001	<0.001	<0.001
Ramsay评分	研究组	48	4.02±0.49	3.99±0.45	4.96±0.64	5.02±0.71	3.77±0.54
	对照组	48	3.97±0.43	3.76±0.41	4.26±0.56	4.27±0.55	3.52±0.46
	t值		0.532	2.624	5.831	5.744	2.382
	P值		0.597	0.010	<0.001	<0.001	0.019

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