Research progress of Treg cells in neuropathic pain

doi:10.3877/cma.j.issn.2095-123X.2025.05.009

Abstract

Abstract:

Neuropathic pain (NP) has emerged as a major threat to human health, yet its underlying mechanisms remain incompletely understood. Current therapeutic approaches for NP are suboptimal, underscoring the urgency to decipher its potential mechanisms and identify novel therapeutic targets and strategies. Recently, increasing evidence suggests that various immune cells and associated cytokines attach great importance to inhibit nociception and promote the resolution of NP. As a subtype of CD4⁺T lymphocytes, regulatory T (Treg) cells exert analgesic effects on NP by secreting inhibitory mediators, suppressing effector cells, and other mechanisms. This review synthesizes the latest advances in Treg cells, their cellular mediators, and their interactions in the context of NP, offering new directions and targets for mechanistic research and therapeutic development in this field.

Key words: Neuropathic pain, Regulatory T cells, Immunoregulation mechanism

Bin Cui, Danhui Wang, Lin Wang, Guoqiang Chen. Research progress of Treg cells in neuropathic pain[J]. Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition), 2025, 15(05): 303-308.

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