Stroke is a major cause of disability and death worldwide, and rehabilitation therapy is crucial to improving patients' quality of life and promoting functional recovery. In recent years, with advances in medical technology and in-depth research on the mechanisms of stroke, significant progress has been made in the field of post-stroke rehabilitation. Currently, a variety of rehabilitation treatment methods are available, including physical therapy, occupational therapy, and speech therapy, among others. However, how to address resource shortages and achieve personalized rehabilitation for patients in clinical practice remains a pressing issue to be resolved. Furthermore, the application of cutting-edge rehabilitation technologies, such as robot-assisted therapy and virtual reality technology, has opened up new possibilities for rehabilitation training, as these tools can enhance patient engagement and improve training outcomes. Meanwhile, multidisciplinary collaboration is also particularly important during the rehabilitation process: integrating expertise from different disciplines enables the provision of comprehensive rehabilitation support for patients. This article focuses on therapeutic approaches, the application of new technologies, and personalized rehabilitation in post-stroke rehabilitation. It also explores future research directions and potential opportunities, aiming to offer a comprehensive perspective and reference for professionals in the field of post-stroke rehabilitation, thereby optimizing the rehabilitation outcomes of stroke patients.