Research progress on the protective effect of astaxanthin on traumatic brain injury

doi:10.3877/cma.j.issn.2095-123X.2019.04.014

Abstract

Abstract:

Traumatic brain injury (TBI) is fatal and has a high disability rate, which is a serious hazard to human health. Secondary cascading injury after TBI is an important cause of poor prognosis. Effective treatment of secondary brain injury is an important part of reducing TBI disability, improving patient prognosis and improving quality of life. Astaxanthin (ATX) is a natural carotenoid with a variety of biological activities. Many studies have shown that ATX has a good effect on fighting acute and chronic damage of the central nervous system, oxidative stress, inflammatory response, improving perfusion, and protecting nerves. The protective mechanism and research progress of ATX on TBI are summarized as follows.

Key words: Traumatic brain injury, Astaxanthin, Oxidative stress, Inflammatory reaction, Neuroprotection

Haoyang Chen, Chong Wang. Research progress on the protective effect of astaxanthin on traumatic brain injury[J]. Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition), 2019, 09(04): 246-250.

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References 43

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作用	研究模型	给药途径	药理作用	参考文献
抗氧化损伤	家兔	口服	SOD↓；TR↓；PON↑	[25]
?	HepG2-C8-ARE-荧光素酶细胞	预培养	GSH↑；Nrf2↑；NQO1↑；HO-1↑；ROS↓	[26]
?	小鼠	侧脑室注射	Nrf2↑；HO-1↑；NQO1↑；GST-1↑	[27]
抗炎作用	小鼠脑神经细胞	预培养	p - Akt ↑；p - MEK ↑；p - ERK ↑；Bcl-2↑；JNK ↓；Bax ↓；Cytochrome C↓；Caspase-3↓；H₂O₂↓	[28]
?	小鼠	口服	IL-1β↓；IL-10↓；TNF-α↓	[29]
?	小鼠	管饲	NF-κB↓；MPO↓；IL-1β↓；TNF-α↓；ICAM-1↓	[30]
?	小胶质细胞	预培养	NF-κB↓；TNF-α↓；JNK↓；CD86↓	[31]
减轻脑水肿	小鼠	腹腔注射	NKCC1 mRNA↓；AQP4↓	[34]
?	体外星形胶质细胞创伤模型	预培养	NF-κB↓；IL-6↓；Caspase-3↓；NKCC1↓；TNF-α↓	[35]
神经保护作用	人体	口服	PLOOH↓	[39]
?	小鼠	口服	ROS↓；HO-1↑；PARP↓；MPP+↓	[41]
?	HT22细胞	预培养	Caspase-3/8/9↓；cleaved PARP↓；ROS↓；Akt/GSK-3β↓；Nrf2↑；HO-1↑	[42]

作用	研究模型	给药途径	药理作用	参考文献
抗氧化损伤	家兔	口服	SOD↓；TR↓；PON↑	[25]
?	HepG2-C8-ARE-荧光素酶细胞	预培养	GSH↑；Nrf2↑；NQO1↑；HO-1↑；ROS↓	[26]
?	小鼠	侧脑室注射	Nrf2↑；HO-1↑；NQO1↑；GST-1↑	[27]
抗炎作用	小鼠脑神经细胞	预培养	p - Akt ↑；p - MEK ↑；p - ERK ↑；Bcl-2↑；JNK ↓；Bax ↓；Cytochrome C↓；Caspase-3↓；H₂O₂↓	[28]
?	小鼠	口服	IL-1β↓；IL-10↓；TNF-α↓	[29]
?	小鼠	管饲	NF-κB↓；MPO↓；IL-1β↓；TNF-α↓；ICAM-1↓	[30]
?	小胶质细胞	预培养	NF-κB↓；TNF-α↓；JNK↓；CD86↓	[31]
减轻脑水肿	小鼠	腹腔注射	NKCC1 mRNA↓；AQP4↓	[34]
?	体外星形胶质细胞创伤模型	预培养	NF-κB↓；IL-6↓；Caspase-3↓；NKCC1↓；TNF-α↓	[35]
神经保护作用	人体	口服	PLOOH↓	[39]
?	小鼠	口服	ROS↓；HO-1↑；PARP↓；MPP+↓	[41]
?	HT22细胞	预培养	Caspase-3/8/9↓；cleaved PARP↓；ROS↓；Akt/GSK-3β↓；Nrf2↑；HO-1↑	[42]

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