Effects of phenobarbital on the neurological behavior and development of neonates with epileptic convulsions

doi:10.3877/cma.j.issn.2095-123X.2019.05.005

Abstract

Abstract:

Objective

To investigate the effect of phenobarbital on neuropsychiatric development in neonates with epileptic convulsions.

Methods

Fifty-nine cases of neonatal epileptic convulsions, admitted to neonatology department of Dongguan Marina Bay Central Hospital from January 2016 to June 2018, were selected as the research object, and they were randomly divided into observation group and the control group. Observation group was treated with phenobarbital electrical and clinical control (without convulsion, without abnormal discharge of cerebral cortex and convulsion wave) and the control group treated by phenobarbital clinical symptoms only control (without convulsion, but there are abnormal discharge of cerebral cortex, convulsion wave). The differences of electroencephalogram (EEG)-clinical symptom treatment results, dosage, sequelae, mental development index and psychomotor development index were compared between the 2 groups.

Results

The recurrence rate of convulsion in the observation group was significantly lower than that in the control group (P<0.05), the normal rate of EEG was significantly higher than that in the control group (P<0.05), and there was no significant difference in the incidence of sequelae (P>0.05). The dosage of phenobarbital in the observation group was significantly higher than that in the control group (P<0.05). There was no significant difference in MDI and PDI scores between the observation group and the control group at the 6^th and 12^th months(P>0.05), while the MDI and PDI scores of the observation group were significantly higher than those of the control group at the 18^th month (P<0.05).

Conclusion

Increase the dose to control the electro-clinical seizure of neonates with epileptic convulsion is more effective than only controlling the seizure of clinical symptoms, and has advantage of the neurological behavior and development of neonates.

Key words: Phenobarbital, Neonates, Convulsions, Neurological behavior

Yanling Chen, Wei Li, Kuidai Chen, Xiaoyu Wang, Kangcheng He, Xiaoxia Wang. Effects of phenobarbital on the neurological behavior and development of neonates with epileptic convulsions[J]. Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition), 2019, 09(05): 277-280.

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References 21

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项目		观察组（n=32）	对照组（n=27）	t/χ²值	P值
性别（男/女）		18/14	17/10	0.273	0.601
胎龄（周）		38.94±1.80	39.19±1.78	0.531	0.598
日龄（d）		16.34±5.95	13.94±4.56	1.711	0.092
出生体质量（g）		3229.19±535.03	3425.19±386.47	1.585	0.118
病因分类		?	?	0.713	0.982
?	缺血缺氧性脑病	10	9	?	?
?	颅内出血（Ⅰ-Ⅱ级）	4	6	?	?
?	胆红素脑损伤	4	4	?	?
?	化脓性脑膜炎	3	2	?	?
?	低血糖	2	2	?	?
?	原因不明	6	7	?	?
用药剂量（mg）		118.53±20.06	71.15±22.41	8.569	<0.001
惊厥复发情况		?	?	2.181	0.029
?	无	18	8	?	?
?	有	14	19	?	?
复查脑电图情况		?	?	2.446	0.014
?	正常	16	6	?	?
?	异常	16	21	?	?
后遗症		?	?	0.958	0.371
?	无	26	19	?	?
?	有	6	8	?	?

项目		观察组（n=32）	对照组（n=27）	t/χ²值	P值
性别（男/女）		18/14	17/10	0.273	0.601
胎龄（周）		38.94±1.80	39.19±1.78	0.531	0.598
日龄（d）		16.34±5.95	13.94±4.56	1.711	0.092
出生体质量（g）		3229.19±535.03	3425.19±386.47	1.585	0.118
病因分类		?	?	0.713	0.982
?	缺血缺氧性脑病	10	9	?	?
?	颅内出血（Ⅰ-Ⅱ级）	4	6	?	?
?	胆红素脑损伤	4	4	?	?
?	化脓性脑膜炎	3	2	?	?
?	低血糖	2	2	?	?
?	原因不明	6	7	?	?
用药剂量（mg）		118.53±20.06	71.15±22.41	8.569	<0.001
惊厥复发情况		?	?	2.181	0.029
?	无	18	8	?	?
?	有	14	19	?	?
复查脑电图情况		?	?	2.446	0.014
?	正常	16	6	?	?
?	异常	16	21	?	?
后遗症		?	?	0.958	0.371
?	无	26	19	?	?
?	有	6	8	?	?

评分	组别	例数	第6个月	第12个月	第18个月
MDI	观察组	32	80.56±6.85	87.56±6.34	94.66±4.35
	对照组	27	81.74±6.36	85.48±6.82	90.96±8.28
	t值	?	0.680	1.214	2.087
	P值	?	0.499	0.230	0.044
PDI	观察组	32	78.91±6.67	95.44±3.53	98.81±4.62
	对照组	27	79.96±7.87	94.85±3.46	96.44±3.77
	t值	?	0.559	0.641	2.130
	P值	?	0.579	0.524	0.037

评分	组别	例数	第6个月	第12个月	第18个月
MDI	观察组	32	80.56±6.85	87.56±6.34	94.66±4.35
	对照组	27	81.74±6.36	85.48±6.82	90.96±8.28
	t值	?	0.680	1.214	2.087
	P值	?	0.499	0.230	0.044
PDI	观察组	32	78.91±6.67	95.44±3.53	98.81±4.62
	对照组	27	79.96±7.87	94.85±3.46	96.44±3.77
	t值	?	0.559	0.641	2.130
	P值	?	0.579	0.524	0.037

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