Research progress in microRNA regulating cognitive function

doi:10.3877/cma.j.issn.2095-123X.2020.01.012

Abstract

Abstract:

MicroRNA (miRNA) widely exists in the nervous system, and could regulate pathophysiological processes, such as synaptic plasticity, neuroinflammation, autophagy, oxidative stress, and toxic protein aggregation, affect learning, memory and other advanced cognitive functions, and participate in the cognition dysfunction-related diseases, including Alzheimer’s disease, post-operative cognitive dysfunction. Moreover, the peripheral changes of miRNA expression could be similar as those in the central nervous system, suggesting that peripheral miRNA might be developed as potential clinical biomarkers for cognition dysfunction-related diseases. This paper have summarized the molecular mechanisms underlying the action of miRNA on the cognitive functions and pathological mechanism of cognitive impairment related diseases, and the progress of miRNA used as biomarkers for cognition dysfunction-related diseases.

Key words: MicroRNA, Cognitive impairment, Learning and memory, Biomarker

Kequn Huang, Lin Liu, Wei Cui, Xiang Wu. Research progress in microRNA regulating cognitive function[J]. Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition), 2020, 10(01): 53-56.

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