To study the application of intravenous midazolam in sedation treatment of traumatic brain injury and its effect on cerebral hemodynamics, respiratory status and long-term prognosis.

Seventy patients with traumatic brain injury admitted to Neurosurgery Department of the Second Affiliated Hospital of Xi’an Medical University from May 2014 to December 2019 were selected and randomly divided into the treatment group (n=35) and the control group (n=35). In the treatment group, midazolam were injected intravenously at a rate of 0.1 mg/(kg·h), while patients in the control group were not given any sedatives or analgesics or other drugs affecting intracranial hemodynamics. Transcranial doppler ultrasonography was used to measure the mean blood flow velocity of the middle cerebral artery, and the parameters such as systolic blood pressure, heart rate and respiratory frequency were collected.

Although the flow velocity of patients in the treatment group decreased, the difference was not statistically significant between the two groups(P>0.05). In addition, the heart rate, systolic blood pressure and respiratory rate of the treatment group were significantly lower than those of the control group, and the difference in respiratory rate was statistically significant (P=0.049). Further analysis of the follow-up data showed that there was no significant difference in the mortality and GOS between the two groups (P>0.05).

Intravenous midazolam can effectively control agitation, and can affect the intracranial hemodynamics and respiratory status of patients to a certain extent, but it has no significant impact on the long-term prognosis of patients with traumatic brain injury.