Migraine and epilepsy disease: a two sample Mendelian randomization study

doi:10.3877/cma.j.issn.2095-123X.2026.02.002

Abstract

Abstract:

Objective

To explore the correlation between migraine and epilepsy using a two sample Mendelian randomization (MR) study method.

Methods

Single nucleotide polymorphism (SNP) information of two samples was obtained from publicly available genome-wide association study (GWAS) databases, and suitable SNPs were selected as instrumental variables. Five methods for MR analysis were employed, including inverse variance weighted (IVW), weighted median estimator (WME), MR-Egger regression, weighted mode, and simple median. Additionally, Cochran's Q test, MR-Egger regression method, funnel plot, and leave-one-out method were used for sensitivity analysis to evaluate the robustness of the results.

Results

This study identified 13 SNPs that satisfied the MR hypothesis. Using the IVW method, it was found that migraine patients have an increased risk of developing epilepsy (OR=1.216, 95%CI: 1.046-1.414, P=0.011), indicating a positive correlation between migraine and epilepsy. Multiple sensitivity analyses showed no heterogeneity (P=0.120) or horizontal pleiotropy (P=0.472) in the study, indicating the robustness of the results.

Conclusions

Comorbid migraine increases the risk of epilepsy, and early prevention and intervention should be implemented to reduce the incidence of epilepsy.

Key words: Epilepsy, Migraine, Mendelian randomization

Jinmei Tan, Shan Wu. Migraine and epilepsy disease: a two sample Mendelian randomization study[J]. Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition), 2026, 16(02): 71-76.

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References 38

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疾病	GWAS ID	样本量	人群	年份	病例数	对照数	SNPs数量
偏头痛	finn-b-G6_MIGRAINE	184 654	欧洲人	2021年	8 547	176 107	16 380 367
癫痫	finn-b-G6_EPLEPSY	182 367	欧洲人	2021年	6 260	176 107	16 380 349

疾病	GWAS ID	样本量	人群	年份	病例数	对照数	SNPs数量
偏头痛	finn-b-G6_MIGRAINE	184 654	欧洲人	2021年	8 547	176 107	16 380 367
癫痫	finn-b-G6_EPLEPSY	182 367	欧洲人	2021年	6 260	176 107	16 380 349

SNP	效应等位基因	其他等位基因	等位基因效应大小	等位基因效应位点频率	标准误	P值
rs10770255	T	A	0.144 3	0.075 09	0.031 4	<0.001
rs113409543	G	C	-0.642 9	0.004 584	0.133 1	<0.001
rs1144709	T	C	-0.095 7	0.250 2	0.019 3	<0.001
rs12828811	G	A	-0.110 5	0.145 2	0.023 7	<0.001
rs138931689	A	G	0.197 0	0.040 63	0.043 1	<0.001
rs143370621	G	A	-0.186 8	0.046 31	0.039 6	<0.001
rs145281382	T	C	0.175 7	0.051 62	0.037 3	<0.001
rs2301798	T	C	-0.177 3	0.062 35	0.034 6	<0.001
rs3003958	A	G	0.088 4	0.330 2	0.017 6	<0.001
rs35877876	T	C	0.198 4	0.046 93	0.039 5	<0.001
rs4849052	C	T	-0.329 8	0.983 4	0.066 0	<0.001
rs7398375	G	C	0.091 2	0.332 5	0.017 8	<0.001
rs9349379	G	A	-0.092 1	0.451 1	0.016 6	<0.001

SNP	效应等位基因	其他等位基因	等位基因效应大小	等位基因效应位点频率	标准误	P值
rs10770255	T	A	0.144 3	0.075 09	0.031 4	<0.001
rs113409543	G	C	-0.642 9	0.004 584	0.133 1	<0.001
rs1144709	T	C	-0.095 7	0.250 2	0.019 3	<0.001
rs12828811	G	A	-0.110 5	0.145 2	0.023 7	<0.001
rs138931689	A	G	0.197 0	0.040 63	0.043 1	<0.001
rs143370621	G	A	-0.186 8	0.046 31	0.039 6	<0.001
rs145281382	T	C	0.175 7	0.051 62	0.037 3	<0.001
rs2301798	T	C	-0.177 3	0.062 35	0.034 6	<0.001
rs3003958	A	G	0.088 4	0.330 2	0.017 6	<0.001
rs35877876	T	C	0.198 4	0.046 93	0.039 5	<0.001
rs4849052	C	T	-0.329 8	0.983 4	0.066 0	<0.001
rs7398375	G	C	0.091 2	0.332 5	0.017 8	<0.001
rs9349379	G	A	-0.092 1	0.451 1	0.016 6	<0.001

暴露	结局	SNP数量	MR方法	OR值	95%CI	P值	异质性检验P值	水平多效性检验P值
			MR-Egger回归法	1.383	0.954~2.007	0.115
			逆方差加权法	1.216	1.046~1.414	0.011
偏头痛	癫痫	13	加权众数法	1.162	0.884~1.527	0.303	0.120	0.472
			简单模型法	1.174	0.869~1.585	0.317
			加权中位数法	1.180	0.994~1.403	0.059

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