对无创脑水肿动态监测仪诊断急性脑损伤的文献进行荟萃分析，评价无创脑水肿动态监测仪对脑出血、颅脑外伤及脑梗死的诊断价值。

使用中国生物医学文献、万方医药、中国知网、PubMed等数据库检索无创脑水肿动态监测仪相关中英文文献。以急性脑损伤患者健侧扰动系数为对照组，对纳入的文献进行质量评价，并提取相关数据进行研究。数据分析采用Review Manager 5.4版软件。检验纳入文献的异质性，采取单篇文献排除法进行敏感性分析，并绘制森林图计算各亚组扰动系数对比的OR值。

最后纳入文献共计8篇，存在异质性，按发病类型进行亚组分析。亚组分析结果：发病后1 d脑出血及颅脑外伤患者大脑患侧扰动系数均显著低于健侧，OR值分别为-2.57（95%CI：-3.01~-2.13）、-0.83（95%CI：-1.02~-0.63），而发病后3、7 d脑出血及颅脑外伤患者大脑患侧扰动系数均显著高于健侧；发病后1、3、7 d脑梗死患者大脑患侧扰动系数均显著高于健侧，OR值分别为0.75（95%CI：0.39~1.10）、0.61（95%CI：0.32~0.90）、0.50（95%CI：0.01~0.99）；发病后脑出血、脑梗死及颅脑外伤患者1~3 d扰动系数变化幅度均显著大于3~7 d，OR值分别为3.30（95%CI：3.11~3.50）、1.03（95%CI：0.08~1.98）、2.23（95%CI：2.09~2.38）。

无创脑水肿动态监测仪对急性脑损伤患者的扰动系数监测符合脑水肿发生的基本病理生理规律，反映了患者脑水肿严重程度变化的动态过程，可作为急性脑损伤患者的临床辅助诊断方法，帮助临床医生动态了解患者的脑水肿情况。

To perform a meta-analysis of non-invasive brain edema dynamic monitor in diagnosis of acute brain injury and evaluate the diagnostic value of non-invasive brain edema dynamic monitor for intracerebral hemorrhage, brain trauma and cerebral infarction.

The literatures of the non-invasive brain edema dynamic monitor were retrieved using the Chinese Biomedical Literature Database, Wanfang Medical Database, Chinese Knowledge Network Journal Database, and the PubMed Database. The cerebral electrical impedance of the brain with healthy side in acute brain injury patients was treated as control. The quality of included literatures was assessed. The relevant data for research was extracted. Statistical analysis was performed Review Manager 5.4 software. The heterogeneity of the literature was tested. The sensitivity analysis was carried out by single literature exclusion method, and the OR value of disturbance coefficient of each subgroup was calculated by drawing forest map.

Eight studies with heterogeneity were included for subgroup analysis according to the onset type. The cerebral electrical impedance was significantly lower than that of healthy side after 1 d of intracerebral hemorrhage and brain trauma, the OR values were -2.57(95%CI: -3.01--2.13) and -0.83(95%CI: -1.02--0.63). The cerebral electrical impedance was significantly higher than that of healthy side after 3 and 7 d of intracerebral hemorrhage and brain trauma. The cerebral electrical impedance was significantly higher than that of healthy side after 1, 3 and 7 d of cerebral infarction, the OR values were 0.75(95%CI: 0.39-1.10), 0.61(95%CI: 0.32-0.90), 0.50(95%CI: 0.31-0.99). The variation amplitude of cerebral electrical impedance during 1-3 d in patients with intracerebral hemorrhage, cerebral infarction and brain trauma was significantly greater than that during 3-7 d after onset, the OR values were 3.30 (95%CI: 3.11-3.50), 1.03 (95%CI: 0.08-1.98), 2.23 (95%CI: 2.09-2.38).

The cerebral electrical impedance of non-invasive brain edema dynamic monitor in patients with acute brain injury accorded with the basic pathophysiological law of brain edema and reflected the dynamic process of changes in the severity of cerebral edema. It can be used as an auxiliary diagnostic method for patients with acute brain injury to help clinicians understand the situation of brain edema in patients at any time during treatment.