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中华脑科疾病与康复杂志(电子版) ›› 2021, Vol. 11 ›› Issue (01) : 9 -13. doi: 10.3877/cma.j.issn.2095-123X.2021.01.003

所属专题: 经典病例 文献

周围神经疾患

肉毒杆菌毒素A型治疗慢性偏头痛的疗效分析(附47例报道)
王嗣嵩1, 任骥1, 熊建平1, 郑宏伟1, 陈昌平1, 孙华东1, 陈永军1, 张桓1, 冯文1, 潘海鹏1,()   
  1. 1. 610000 成都,西南医科大学附属成都三六三医院神经外科
  • 收稿日期:2021-01-04 出版日期:2021-02-15
  • 通信作者: 潘海鹏
  • 基金资助:
    四川省医学会青年创新科研课题(Q19021)

Analysis of botulinum toxin type A in the treatment of chronic migraine: a report of 47 cases

Sisong Wang1, Ji Ren1, Jianping Xiong1, Hongwei Zheng1, Changping Chen1, Huadong Sun1, Yongjun Chen1, Huan Zhang1, Wen Feng1, Haipeng Pan1,()   

  1. 1. Department of Neurosurgery, Chengdu 363 Hospital Affiliated to Southwest Medical University, Chengdu 610000, China
  • Received:2021-01-04 Published:2021-02-15
  • Corresponding author: Haipeng Pan
引用本文:

王嗣嵩, 任骥, 熊建平, 郑宏伟, 陈昌平, 孙华东, 陈永军, 张桓, 冯文, 潘海鹏. 肉毒杆菌毒素A型治疗慢性偏头痛的疗效分析(附47例报道)[J]. 中华脑科疾病与康复杂志(电子版), 2021, 11(01): 9-13.

Sisong Wang, Ji Ren, Jianping Xiong, Hongwei Zheng, Changping Chen, Huadong Sun, Yongjun Chen, Huan Zhang, Wen Feng, Haipeng Pan. Analysis of botulinum toxin type A in the treatment of chronic migraine: a report of 47 cases[J]. Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition), 2021, 11(01): 9-13.

目的

探讨使用肉毒杆菌毒素A型(BoNTA)治疗慢性偏头痛(CM)的疗效。

方法

回顾性分析西南医科大学附属成都三六三医院神经外科自2018年6月至2019年6月收治的47例CM患者的临床资料。所有患者均使用BoNTA治疗,采用术前和术后问卷调查比较疼痛的严重程度和每月疼痛发作次数。

结果

治疗前患者报告的平均疼痛发作次数中位数为12(9,16)次/月,治疗后减少到3(1,5)次/月。术前患者疼痛强度的中位数为7(7,8)分,治疗后降低至1(1,5)分。11例患者术后疼痛完全消除,28例患者症状明显缓解,3例患者症状有效缓解,仅5例患者术后没有任何明显的改善。平均随访时间为11.06个月。

结论

对于CM患者,BoNTA治疗可提供良好的治疗效果。

Objective

To study the therapeutic effect of botulinum toxin serotype A (BoNTA) in the treatment of chronic migraine (CM).

Methods

A retrospective analysis was performed on 47 patients with CM admitted to the Department of Neurosurgery, Chengdu 363 Hospital from June 2018 to June 2019. All patients were treated with BoNTA. The severity of pain and the number of pain episodes per month were compared by preoperative and postoperative questionnaires.

Results

The average pain incidence reported by the patients before operation was 12(9,16) times per month, but the average pain incidence reported by the patients after operation was reduced to 3(1,5) times per month. The mean pain score also decreased from 7(7,8) points before surgery to 1(1,5) points after injection. Eleven patients reported pain free after injection, 28 patients reported significant relief of pain, 3 patients reported effective relief of pain, and only 5 patients reported no significant postoperative improvement. The mean follow-up time was 11.06 months.

Conclusion

BoNTA is a feasible and promising treatment for CM.

图1 常用注射位点示意图
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