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中华脑科疾病与康复杂志(电子版) ›› 2021, Vol. 11 ›› Issue (02) : 109 -115. doi: 10.3877/cma.j.issn.2095-123X.2021.02.010

综述

术中肿瘤荧光剂应用的研究进展
陈立华1, 夏勇1, 孙恺1, 陈文锦1, 张洪钿1, 徐如祥1,()   
  1. 1. 610072 成都,四川省医学科学院·四川省人民医院神经外科
  • 收稿日期:2021-02-16 出版日期:2021-04-15
  • 通信作者: 徐如祥

Research progress of the application of intraoperative tumor fluorescent agents

Lihua Chen1, Yong Xia1, Kai Sun1, Wenjin Chen1, Hongtian Zhang1, Ruxiang Xu1,()   

  1. 1. Department of Neurosurgery, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, Chengdu 610072, China
  • Received:2021-02-16 Published:2021-04-15
  • Corresponding author: Ruxiang Xu
引用本文:

陈立华, 夏勇, 孙恺, 陈文锦, 张洪钿, 徐如祥. 术中肿瘤荧光剂应用的研究进展[J/OL]. 中华脑科疾病与康复杂志(电子版), 2021, 11(02): 109-115.

Lihua Chen, Yong Xia, Kai Sun, Wenjin Chen, Hongtian Zhang, Ruxiang Xu. Research progress of the application of intraoperative tumor fluorescent agents[J/OL]. Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition), 2021, 11(02): 109-115.

肿瘤荧光剂应用于颅内肿瘤手术切除,可通过荧光定位肿瘤并标记肿瘤边界,引导安全、有效地切除肿瘤,提高肿瘤全切率和神经血管的功能保护率,从而延长患者的无进展生存期。目前常用的肿瘤荧光剂有荧光素钠、5-氨基乙酰丙酸、吲哚青绿,各有其优势和局限性,术中选择何种成像方式需要权衡。本文对常见的肿瘤荧光剂的特性、作用机制、使用方法、优势与局限性、临床应用等进行综述。

The application of tumor fluorescent agent in the surgical resection of intracranial tumor can guide the safe and effective resection of tumor by locating the tumor and marking the tumor boundary, improve the total resection rate of tumor and the protection rate of neurovascular function, so as to prolong the progression free survival of patients. Currently, the commonly used tumor fluorescent agents are fluorescein sodium, 5-aminolevulinic acid, indocyanine green, each of which has its own advantages and limitations, the choice of intraoperative imaging mode needs to be weighed. This article reviews the characteristics, mechanism, methods of use, advantages and limitations, and clinical application of common tumor fluorescent agents.

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