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中华脑科疾病与康复杂志(电子版) ›› 2021, Vol. 11 ›› Issue (02) : 116 -120. doi: 10.3877/cma.j.issn.2095-123X.2021.02.011

综述

心肺复苏后全脑缺血再灌注损伤的研究进展
康晓宇1, 刘丽旭1,()   
  1. 1. 100068 北京,首都医科大学康复医学院·中国康复研究中心北京博爱医院神经康复一科
  • 收稿日期:2021-03-16 出版日期:2021-04-15
  • 通信作者: 刘丽旭
  • 基金资助:
    中国康复研究中心科研项目(2017ZX-11)

Progress of global cerebral ischemia reperfusion injury after cardiopulmonary resuscitation

Xiaoyu Kang1, Lixu Liu1,()   

  1. 1. Department of Neurological Rehabilitation I, School of Rehabilitation Medicine, Capital Medical University, Beijing Bo’ai Hospital, China Rehabilitation Research Centre, Beijing 100068, China
  • Received:2021-03-16 Published:2021-04-15
  • Corresponding author: Lixu Liu
引用本文:

康晓宇, 刘丽旭. 心肺复苏后全脑缺血再灌注损伤的研究进展[J/OL]. 中华脑科疾病与康复杂志(电子版), 2021, 11(02): 116-120.

Xiaoyu Kang, Lixu Liu. Progress of global cerebral ischemia reperfusion injury after cardiopulmonary resuscitation[J/OL]. Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition), 2021, 11(02): 116-120.

心肺复苏后的脑功能障碍是影响患者病死率和致残率的主要因素,然而迄今为止针对心肺复苏后全脑缺血再灌注损伤患者的治疗手段仍非常有限,如何针对心脏骤停后全脑缺血再灌注损伤进行有效的脑保护,也是目前亟待解决的一大难题。因此,本文针对心肺复苏后全脑缺血再灌注损伤的概念、流行病学、病理生理机制及治疗手段的研究进展作一综述。

Brain dysfunction after cardiopulmonary resuscitation is the main factor affecting the mortality and morbidity of patients. However, the treatment of global cerebral ischemia-reperfusion injury after cardiopulmonary resuscitation is still very limited. How to effectively protect the brain after global cerebral ischemia-reperfusion injury caused by cardiac arrest is a big problem to be solved urgently. This review is based on the concept, epidemiology, pathophysiological mechanisms and therapies of global cerebral ischemia reperfusion injury after cardiopulmonary resuscitation in order to introduce its research progress.

图1 全脑缺血再灌注损伤的病理生理过程
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