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中华脑科疾病与康复杂志(电子版) ›› 2021, Vol. 11 ›› Issue (03) : 139 -146. doi: 10.3877/cma.j.issn.2095-123X.2021.03.003

临床研究

基于多数据库分析PARK2在泛癌中的表达与突变
豆雅楠1, 费晓炜1, 魏嘉良1, 费舟1,()   
  1. 1. 710032 西安,空军军医大学第一附属医院神经外科
  • 收稿日期:2021-05-18 出版日期:2021-06-15
  • 通信作者: 费舟

Analysis of the expression and mutation of PARK2 in pan-cancer based on multiple databases

Ya’nan Dou1, Xiaowei Fei1, Jialiang Wei1, Zhou Fei1,()   

  1. 1. Department of Neurosurgery, The First Affiliated Hospital of Air Force Military Medical University, Xi’an 710032, China
  • Received:2021-05-18 Published:2021-06-15
  • Corresponding author: Zhou Fei
引用本文:

豆雅楠, 费晓炜, 魏嘉良, 费舟. 基于多数据库分析PARK2在泛癌中的表达与突变[J/OL]. 中华脑科疾病与康复杂志(电子版), 2021, 11(03): 139-146.

Ya’nan Dou, Xiaowei Fei, Jialiang Wei, Zhou Fei. Analysis of the expression and mutation of PARK2 in pan-cancer based on multiple databases[J/OL]. Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition), 2021, 11(03): 139-146.

目的

分析PARK2在泛癌中的表达与突变。

方法

采用肿瘤免疫数据库TIMER2.0分析PARK2在33种肿瘤中的mRNA表达水平,探讨癌症相关成纤维细胞浸润水平与癌症基因组图谱(TCGA)不同癌症类型中PARK2基因表达的潜在关系;采用GEPIA数据库获得所有TCGA中不同PARK2表达的肿瘤患者的总生存期(OS)和无病生存期(DFS);采用cBioportal数据库进行泛癌种基因突变汇总并获得PARK2功能结构域图上的具体的突变位点信息;采用STRING数据库得到PARK2的蛋白相互作用网络。

结果

PARK2在大多数癌症中高表达且与肿瘤患者的预后存在明显相关性。PARK2的表达与宫颈鳞癌、腺癌、结肠癌、食管癌及头颈鳞状细胞癌等癌症中的肿瘤相关成纤维细胞浸润水平相关。PARK2基因的突变和(或)缺失也参与了PARK2的功能发挥。

结论

PARK2的表达与临床预后、免疫浸润等存在统计学相关性,将有助于从临床肿瘤样本的角度理解PARK2在肿瘤发生中的作用,为多癌肿的治疗提供一种潜在的靶向治疗策略。

Objective

To analyze the expression and mutation of PARK2 in pan-cancer.

Methods

The tumor immune database TIMER2.0 was used to analyze the mRNA expression level of PARK2 in 33 tumors, and to investigate the potential relationship between the level of cancer-related fibroblast infiltration and PARK2 gene expression in different cancer types of The Cancer Genome Atlas (TCGA); the GEPIA database was used to obtain the overall survival and disease-free survival of PARK2 in all TCGA tumors; the cBioportal database was used to summarize the mutations of pan-cancer genes and obtain the specific mutation site information on the PARK2 functional domain map; the STRING database was used to obtain the protein interaction network of PARK2.

Results

PARK2 is highly expressed in most cancers and has a significant correlation with the prognosis of tumor patients. The expression of PARK2 was correlated with the infiltration of tumor associated fibroblasts in cervical squamous cell carcinoma and endocervical adenocarcinoma, colon adenocarcinoma, esophageal carcinoma, head and neck squamous cell carcinoma. Mutations and/or deletions of PARK2 gene are also involved in the function of PARK2.

Conclusion

The pan-cancer analysis of PARK2 showed that PARK2 expression was statistically correlated with clinical prognosis, immune invasion, etc., which will help to understand the role of in tumorigenesis from the perspective of clinical tumor samples and provide a potential targeted therapeutic strategy for the treatment of multiple cancers.

图1 PARK2在各个肿瘤中的mRNA和病理分期的表达
图2 PARK2高表达/低表达对生存的影响
图3 TCGA包含的不同肿瘤类型中PARK2的遗传变异情况
图4 免疫细胞的浸润水平与TCGA不同癌症类型中PARK2基因表达之间的相关性
图5 PARK2结合蛋白和PARK2表达相关基因分析
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