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中华脑科疾病与康复杂志(电子版) ›› 2022, Vol. 12 ›› Issue (06) : 365 -369. doi: 10.3877/cma.j.issn.2095-123X.2022.06.009

短篇论著

脑深部电刺激术治疗梅杰综合征的两年疗效分析
徐武1,(), 姜成荣1, 种玉龙1, 梁维邦1   
  1. 1. 210008 南京,南京大学医学院附属鼓楼医院神经外科
  • 收稿日期:2022-05-09 出版日期:2022-12-15
  • 通信作者: 徐武

Two-year operative effect of deep brain stimulation in Meige syndrome

Wu Xu1,(), Chengrong Jiang1, Yulong Chong1, Weibang Liang1   

  1. 1. Department of Neurosurgery, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China
  • Received:2022-05-09 Published:2022-12-15
  • Corresponding author: Wu Xu
引用本文:

徐武, 姜成荣, 种玉龙, 梁维邦. 脑深部电刺激术治疗梅杰综合征的两年疗效分析[J]. 中华脑科疾病与康复杂志(电子版), 2022, 12(06): 365-369.

Wu Xu, Chengrong Jiang, Yulong Chong, Weibang Liang. Two-year operative effect of deep brain stimulation in Meige syndrome[J]. Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition), 2022, 12(06): 365-369.

目的

分析双侧脑深部电刺激术(DBS)治疗梅杰综合征(MS)的2年内临床效果。

方法

选取南京大学医学院附属鼓楼医院神经外科自2014年1月至2017年12月进行手术治疗的11例MS患者为研究对象,其中1例行双侧丘脑底核-DBS,10例行双侧苍白球-DBS。在术前和开机后1个月、6个月、2年时运用Burke-Fahn-Maisden肌张力障碍量表(BFMdrs)评估患者的运动功能,评价症状改善情况。

结果

11例患者术前BFMdrs评分为(14.64±1.57)分,开机后1个月、6个月、2年时的评分分别为(8.18±1.33)、(4.55±1.21)、(4.09±1.22)分,平均改善率分别为44.10%、68.94%、72.05%,与术前比较差异均有统计学意义(P<0.05)。

结论

双侧DBS治疗MS效果确切,远期疗效优于近期,提高了患者的生存质量。

Objective

To investigate the improvement of symptoms in recent to two years after bilateral deep brain stimulation (DBS) for Meige syndrome (MS).

Methods

Eleven MS patients were treated from January 2014 to December 2017 in Neurosurgery Department of the Affiliated Drum Tower Hospital of Nanjing University Medical School with bilateral DBS, including 1 case with Stn-DBS and 10 cases with Gpi-DBS. The patients were evaluated by Burke-Fahn-Maisden dystonia rating scale (BFMdrs) before operation, and 1 month, 6 months, 2 years after the pulse stimulator were turned on respectively.

Results

The BFMdrs score of 11 patients before operation was (14.64±1.57), and the scores at 1 month, 6 months, and 2 years after operation were (8.18±1.33), (4.55±1.21), and (4.09±1.22), respectively, with statistical significance compared with that before operation (P<0.05). The average improvement rate at 1 month, 6 months, and 2 years after operation were 44.10%, 68.94%, and 72.05%, respectively.

Conclusion

Bilateral DBS has a definite effect on MS, and the long-term effect is better than the short-term effect, which improves the quality of life of MS patients.

图1 1例苍白球钙化梅杰综合征患者的术前CT资料
表1 11例患者的基本资料及植入设备、靶点坐标
图2 术中C型臂X光机确认电极无移位
表2 11例患者术前及开机后1个月、6个月、2年时的BFMdrs运动功能评分和改善率
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