切换至 "中华医学电子期刊资源库"

中华脑科疾病与康复杂志(电子版) ›› 2023, Vol. 13 ›› Issue (04) : 235 -240. doi: 10.3877/cma.j.issn.2095-123X.2023.04.007

综述

马黛茶对脑血管疾病防治作用的研究进展
杨梦琦, 马慧芬, 訾阳, 王楠, 杜冰玉, 常万鹏, 于少泓()   
  1. 250355 济南,山东中医药大学康复医学院
    100191 北京,国家卫生健康委能力建设和继续教育中心
    250001 济南,山东中医药大学第二附属医院康复医学科
    250300 济南,山东中医药大学医学院
  • 收稿日期:2022-05-25 出版日期:2023-08-15
  • 通信作者: 于少泓

Research progress of yerba mate tea on prevention and treatment of cerebrovascular disease

Mengqi Yang, Huifen Ma, Yang Zi, Nan Wang, Bingyu Du, Wanpeng Chang, Shaohong Yu()   

  1. School of Rehabilitation Medicine, Shandong University of Traditional Chinese Medicine, Ji'nan 250355, China
    National Health Commission Capacity Building and Continuing Education Center, Beijing 100191, China
    Department of Rehabilitation Medicine, Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Ji'nan 250001, China
    School of Medicine, Shandong University of Traditional Chinese Medicine, Ji'nan 250300, China
  • Received:2022-05-25 Published:2023-08-15
  • Corresponding author: Shaohong Yu
  • Supported by:
    National Ministry of Science and Technology International Cooperation and Exchange Program(2010016); Health Science and Technology Development Program of Shandong Province(2018WS201); Science and Technology Program of Higher Education in Shandong Province(J16LK09)
引用本文:

杨梦琦, 马慧芬, 訾阳, 王楠, 杜冰玉, 常万鹏, 于少泓. 马黛茶对脑血管疾病防治作用的研究进展[J]. 中华脑科疾病与康复杂志(电子版), 2023, 13(04): 235-240.

Mengqi Yang, Huifen Ma, Yang Zi, Nan Wang, Bingyu Du, Wanpeng Chang, Shaohong Yu. Research progress of yerba mate tea on prevention and treatment of cerebrovascular disease[J]. Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition), 2023, 13(04): 235-240.

脑血管疾病具有高致残率和高死亡率的特点,严重威胁人类的健康。天然药物马黛茶具有安全、多成分、多靶点的作用特点,可以通过降血糖、降血脂、抗氧化、调节炎症反应、改善血液流变性、改善血管内皮功能障碍等多种作用机制切断脑血管疾病发生途径,改善脑血管系统功能,发挥脑血管疾病的防治作用。本文围绕上述内容进行综述,为深入开展马黛茶对脑血管疾病的防治作用研究、扩大马黛茶临床应用提供参考。

Cerebrovascular diseases are characterized by high disability and high mortality rates, seriously threatening human health. Natural medicine yerba mate tea has the characteristics of safety, multi-component, and multi-target action. It can cut off the pathway of cerebrovascular diseases and improve the function of the cerebrovascular system through various mechanisms of action such as hypoglycemia, hypolipidemia, antioxidation, regulation of inflammatory response, improvement of blood rheology, and improvement of vascular endothelial dysfunction, which can play a role in the prevention and treatment of cerebrovascular diseases. This paper reviews the above aspects to provide a reference for further research on the preventive and curative effects of yerba mate tea on cerebrovascular diseases and to expand the clinical application of yerba mate tea.

[1]
汤志辉,黄巍,罗飞,等.自发性脑出血患者流行病学特点与死亡影响因素分析[J].中华神经创伤外科电子杂志, 2022, 8(4): 224-228. DOI: 10.3877/cma.j.issn.2095-9141.2022.04.006.
[2]
李松岩,左言辉.视觉反馈平衡训练联合功能性电刺激治疗对脑卒中后偏瘫患者平衡功能及下肢功能的影响[J].中华脑科疾病与康复杂志(电子版), 2022, 12(4): 217-220. DOI: 10.3877/cma.j.issn.2095-123X.2022.04.005.
[3]
Li L, Su C, Chen X, et al. Chlorogenic acids in cardiovascular disease: a review of dietary consumption, pharmacology, and pharmacokinetics[J]. J Agric Food Chem, 2020, 68(24): 6464-6484. DOI: 10.1021/acs.jafc.0c01554.
[4]
Liu D, Wang H, Zhang Y, et al. Protective effects of chlorogenic acid on cerebral ischemia/reperfusion injury rats by regulating oxidative stress-related Nrf2 pathway[J]. Drug Des Devel Ther, 2020, 14: 51-60. DOI: 10.2147/DDDT.S228751.
[5]
Garcia-Lazaro RS, Lamdan H, Caligiuri LG, et al. In vitro and in vivo antitumor activity of Yerba mate extract in colon cancer models[J]. J Food Sci, 2020, 85(7): 2186-2197. DOI: 10.1111/1750-3841.15169.
[6]
韩晴,杨英兰,韩茜茜,等.马黛茶成分及疗效的研究进展[J].山西医药杂志, 2020, 49(4): 414-417. DOI: 10.3969/j.issn.0253-9926.2020.04.018.
[7]
Gan RY, Zhang D, Wang M, et al. Health benefits of bioactive compounds from the genus Ilex, a source of traditional caffeinated beverages[J]. Nutrients, 2018, 10(11): 1682. DOI: 10.3390/nu10111682.
[8]
任忠梅,张安新,邢春丽.急性缺血性脑卒中患者血清因子、肺功能变化及其与阻塞型睡眠呼吸暂停综合征的关系[J].中华脑科疾病与康复杂志(电子版), 2019, 9(3): 137-141. DOI: 10.3877/cma.j.issn.2095-123X.2019.03.003.
[9]
贾敏,庄慧魁,杨军.天蝎散Ⅰ号方治疗缺血性中风恢复期临床观察[J].山东中医杂志, 2019, 38(8): 754-757. DOI: 10.16295/j.cnki.0257-358x.2019.08.010.
[10]
高红莉,刘昭纯,陈强,等.马黛茶对高脂血症大鼠血液流变学及心肌ATP酶活性的影响[J].中国老年学杂志, 2014, 34(24): 6991-6993. DOI: 10.3969/j.issn.1005-9202.2014.24.067.
[11]
井静,于京芳,张铁峰.马黛茶改善非酒精性脂肪性肝病痰瘀互结证血脂水平疗效分析[J].临床军医杂志, 2017, 45(7): 683-684. DOI: 10.16680/j.1671-3826.2017.07.08.
[12]
于少泓.马黛通络饮对APOE基因敲除小鼠脂质代谢的影响[J].环球中医药, 2017, 10(9): 957-961. DOI: 10.3969/j.issn.1674-1749.2017.09.006.
[13]
Conceição EP, Kaezer AR, Peixoto-Silva N, et al. Effects of Ilex paraguariensis (yerba mate) on the hypothalamic signalling of insulin and leptin and liver dysfunction in adult rats overfed during lactation[J]. J Dev Orig Health Dis, 2017, 8(1): 123-132. DOI: 10.1017/S2040174416000519.
[14]
de Meneses Fujii TM, Jacob PS, Yamada M, et al. Yerba mate (Ilex paraguariensis) modulates NF-kappaB pathway and AKT expression in the liver of rats fed on a high-fat diet[J]. Int J Food Sci Nutr, 2014, 65(8): 967-976. DOI: 10.3109/09637486.2014.945153.
[15]
曹志伟,刘倩,李静,等.三酰甘油血糖指数纵向轨迹对新发心脑血管疾病的影响研究[J].中国全科医学, 2022, 25(5): 554-657; 554-560, 657. DOI: 10.12114/j.issn.1007-9572.2021.01.320.
[16]
Arçari DP, Bartchewsky W Jr, dos Santos TW, et al. Anti-inflammatory effects of yerba maté extract (Ilex paraguariensis) ameliorate insulin resistance in mice with high fat diet-induced obesity[J]. Mol Cell Endocrinol, 2011, 335(2): 110-115. DOI: 10.1016/j.mce.2011.01.003.
[17]
Hussein GM, Matsuda H, Nakamura S, et al. Mate tea (Ilex paraguariensis) promotes satiety and body weight lowering in mice: involvement of glucagon-like peptide-1[J]. Biol Pharm Bull, 2011, 34(12): 1849-1855. DOI: 10.1248/bpb.34.1849.
[18]
Kang YR, Lee HY, Kim JH, et al. Anti-obesity and anti-diabetic effects of yerba mate (Ilex paraguariensis) in C57BL/6J mice fed a high-fat diet[J]. Lab Anim Res, 2012, 28(1): 23-29. DOI: 10.5625/lar.2012.28.1.23.
[19]
Balsan G, Pellanda LC, Sausen G, et al. Effect of yerba mate and green tea on paraoxonase and leptin levels in patients affected by overweight or obesity and dyslipidemia: a randomized clinical trial[J]. Nutr J, 2019, 18(1): 5. DOI: 10.1186/s12937-018-0426-y.
[20]
田晶,蔡欣池,任晶,等.内皮细胞功能障碍参与动脉粥样硬化发病的研究进展[J].生理科学进展, 2021, 52(5): 357-361. DOI: 10.3969/j.issn.0559-7765.2021.05.007.
[21]
于少泓.马黛通络饮对动脉粥样硬化小鼠血管内皮损伤的保护作用[J].新中医, 2017, 49(10): 1-4. DOI: 10.13457/j.cnki.jncm.2017.10.001.
[22]
González Arbeláez LF, Fantinelli JC, Ciocci Pardo A, et al. Effect of an Ilex paraguariensis (yerba mate) extract on infarct size in isolated rat hearts: the mechanisms involved[J]. Food Funct, 2016, 7(2): 816-824. DOI: 10.1039/c5fo01255d.
[23]
Suzuki A, Yamamoto N, Jokura H, et al. Chlorogenic acid attenuates hypertension and improves endothelial function in spontaneously hypertensive rats[J]. J Hypertens, 2006, 24(6): 1065-1073. DOI: 10.1097/01.hjh.0000226196.67052.c0.
[24]
Tom EN, Girard-Thernier C, Demougeot C. The Janus face of chlorogenic acid on vascular reactivity: a study on rat isolated vessels[J]. Phytomedicine, 2016, 23(10): 1037-1042. DOI: 10.1016/j.phymed.2016.06.012.
[25]
Gebara KS, Gasparotto-Junior A, Santiago PG, et al. Daily intake of chlorogenic acids from consumption of maté (Ilex paraguariensis A. St.-Hil.) traditional beverages[J]. J Agric Food Chem, 2017, 65(46): 10093-10100. DOI: 10.1021/acs.jafc.7b04093.
[26]
Wu C, Luan H, Zhang X, et al. Chlorogenic acid protects against atherosclerosis in ApoE-/- mice and promotes cholesterol efflux from RAW264.7 macrophages[J]. Plos One, 2014, 9(9): e95452. DOI: 10.1371/journal.pone.0095452.
[27]
Fuentes E, Caballero J, Alarcón M, et al. Chlorogenic acid inhibits human platelet activation and thrombus formation[J]. PLoS One, 2014, 9(3): e90699. DOI: 10.1371/journal.pone.0090699.
[28]
马岱朝,陈文博,陈亮,等.进展性脑梗死的高危因素及对不同中医证型病情进展的影响[J].山东中医杂志, 2020, 39(8): 814-831; 814-819, 831. DOI: 10.16295/j.cnki.0257-358x.2020.08.010.
[29]
许立培.马黛茶改善瘀血体质临床研究[D].济南:山东中医药大学, 2014.
[30]
于少泓.马黛多酚对动脉粥样硬化形成早期的干预机制研究[D].济南:山东大学, 2015.
[31]
李斌,周宇,马勇,等. Toll样受体4相关信号通路在缺血性脑卒中炎症损伤中的研究进展[J].中华神经医学杂志, 2023, 22(2): 205-211. DOI: 10.3760/cma.j.cn115354-20220706-00473.
[32]
欧春影,李传玲,安晓雷,等.急性脑梗死患者血清BDNF、IL-6和TNF-α含量与血管性认知障碍关系的临床分析[J].中华脑科疾病与康复杂志(电子版), 2019, 9(3): 163-167. DOI: 10.3877/cma.j.issn.2095-123X.2019.03.009.
[33]
Borges MC, Vinolo MA, Nakajima K, et al. The effect of mate tea (Ilex paraguariensis) on metabolic and inflammatory parameters in high-fat diet-fed Wistar rats[J]. Int J Food Sci Nutr, 2013, 64(5): 561-569. DOI: 10.3109/09637486.2012.759188.
[34]
Puangpraphant S, Dia VP, de Mejia EG, et al. Yerba mate tea and mate saponins prevented azoxymethane-induced inflammation of rat colon through suppression of NF-κB p65ser(311) signaling via IκB-α and GSK-3β reduced phosphorylation[J]. Biofactors, 2013, 39(4): 430-440. DOI: 10.1002/biof.1083.
[35]
Hebeda CB, Bolonheis SM, Nakasato A, et al. Effects of chlorogenic acid on neutrophil locomotion functions in response to inflammatory stimulus[J]. J Ethnopharmacol. 2011, 135(2): 261-269. DOI: 10.1016/j.jep.2011.02.033.
[36]
吴愿如,黄华,曾彩凤,等.血清小而密低密度脂蛋白、超氧化物歧化酶水平与缺血性脑血管疾病患者病情严重程度的相关性研究[J].实用心脑肺血管病杂志, 2019, 27(11): 25-28. DOI: 10.3969/j.issn.1008-5971.2019.11.006.
[37]
高红莉,曲晓兰,刘昭纯.马黛茶对高脂血症小鼠血脂及抗氧化作用的影响[J].时珍国医国药, 2013, 24(8): 1856-1858. DOI: 10.3969/j.issn.1008-0805.2013.08.022.
[38]
Saraiva BR, Vital ACP, Anjo FA, et al. Effect of yerba mate (Ilex paraguariensis A. St.-Hil.) addition on the functional and technological characteristics of fresh cheese[J]. J Food Sci Technol, 2019, 56(3): 1256-1265. DOI: 10.1007/s13197-019-03589-w.
[39]
Piovezan-Borges AC, Valério-Júnior C, Gonçalves IL, et al. Antioxidant potential of yerba mate (Ilex paraguariensis St. Hil.) extracts in Saccharomyces cerevisae deficient in oxidant defense genes[J]. Braz J Biol, 2016, 76(2): 539-544. DOI: 10.1590/1519-6984.01115.
[40]
高红莉,曲晓兰,刘昭纯.马黛茶多酚对大鼠脑缺血再灌注损伤的保护作用[J].中药药理与临床, 2013, 29(1): 75-77. DOI: 10.13412/j.cnki.zyyl.2013.01.026.
[41]
Jung HJ, Im SS, Song DK, et al. Effects of chlorogenic acid on intracellular calcium regulation in lysophosphatidylcholine-treated endothelial cells[J]. BMB Rep, 2017, 50(6): 323-328. DOI: 10.5483/bmbrep.2017.50.6.182.
[42]
Pereira AAF, Tirapeli KG, Chaves-Neto AH, et al. Ilex paraguariensis supplementation may be an effective nutritional approach to modulate oxidative stress during perimenopause[J]. Exp Gerontol, 2017, 90: 14-18. DOI: 10.1016/j.exger.2017.01.011.
[43]
Wan CW, Wong CN, Pin WK, et al. Chlorogenic acid exhibits cholesterol lowering and fatty liver attenuating properties by up-regulating the gene expression of PPAR-α in hypercholesterolemic rats induced with a high-cholesterol diet[J]. Phytother Res, 2013, 27(4): 545-551. DOI: 10.1002/ptr.4751.
[44]
Preetha Rani MR, Anupama N, Sreelekshmi M, et al. Chlorogenic acid attenuates glucotoxicity in H9c2 cells via inhibition of glycation and PKC α upregulation and safeguarding innate antioxidant status[J]. Biomed Pharmacother, 2018, 100: 467-477. DOI: 10.1016/j.biopha.2018.02.027.
[45]
Bhandarkar NS, Brown L, Panchal SK. Chlorogenic acid attenuates high-carbohydrate, high-fat diet-induced cardiovascular, liver, and metabolic changes in rats[J]. Nutr Res, 2019, 62: 78-88. DOI: 10.1016/j.nutres.2018.11.002.
[1] 马艳波, 华扬, 刘桂梅, 孟秀峰, 崔立平. 中青年人颈动脉粥样硬化病变的相关危险因素分析[J]. 中华医学超声杂志(电子版), 2023, 20(08): 822-826.
[2] 王友芳, 李兴超, 朱晓松, 刘清敏, 张建国, 杨淑红, 相然, 张蒙蒙, 车峰远. 预后营养指数对急性颅内动脉粥样硬化性大血管闭塞患者预后评估价值分析[J]. 中华危重症医学杂志(电子版), 2023, 16(03): 193-197.
[3] 秦玲玲, 游兆媛, 丁舒, 王晓莉, 朱萌. 基于遗忘曲线规律的随访对冠状动脉粥样硬化性心脏病介入治疗患者自我管理行为的影响[J]. 中华危重症医学杂志(电子版), 2022, 15(06): 481-485.
[4] 谢恩睿, 段一璇, 刘畅, 邓捷. 利用随机森林联合人工神经网络基于外周血细胞易感基因建立冠心病诊断模型[J]. 中华细胞与干细胞杂志(电子版), 2023, 13(01): 19-26.
[5] 任丽, 吴锡骅, 刘婷, 梅益彰. 沉默LncRNA MEG3调控miR-424-5p/FoxO1对氧化型低密度脂蛋白诱导的动脉粥样硬化的保护机制[J]. 中华细胞与干细胞杂志(电子版), 2022, 12(06): 335-345.
[6] 关明函, 薛志强. 右美托咪定改善大鼠脑缺血再灌注后脑损伤的研究[J]. 中华神经创伤外科电子杂志, 2023, 09(05): 270-276.
[7] 刘宏达, 邵祥忠, 李林, 许小伟. 海安地区动脉粥样硬化性脑梗死患者CYP2C19基因多态性及与氯吡格雷抵抗的关系[J]. 中华神经创伤外科电子杂志, 2023, 09(04): 234-240.
[8] 陶璐, 初楠, 韩洁, 白春英, 逄雯丽, 余海源. 血清PECAM-1、Sirt1水平与2型糖尿病患者颈动脉粥样硬化的关系[J]. 中华临床医师杂志(电子版), 2023, 17(03): 291-296.
[9] 冯佳佳, 刘丹, 张广炜, 金丽霞. microRNA与脑动脉粥样硬化斑块破裂的研究新进展[J]. 中华临床医师杂志(电子版), 2022, 16(06): 601-604.
[10] 杨占奇, 钟绍婷, 谢焱, 张琼阁, 赵红薇, 张宏林, 王宏宇. 北京市古城社区卫生服务中心慢性病管理现况浅析[J]. 中华临床医师杂志(电子版), 2022, 16(06): 474-480.
[11] 李世凯, 梁佳, 何艳艳, 于毅, 李天晓, 常金龙, 贺迎坤. 兔颈动脉粥样硬化性狭窄模型在介入治疗的应用进展[J]. 中华介入放射学电子杂志, 2023, 11(04): 357-362.
[12] 熊鑫, 邓勇志. 基于血管内超声的机器学习在冠状动脉病变中的研究进展[J]. 中华诊断学电子杂志, 2023, 11(03): 153-157.
[13] 邱令智, 胡萍, 罗婷, 鄢华. 脂蛋白(a)与心房颤动关系的研究进展[J]. 中华脑血管病杂志(电子版), 2023, 17(03): 280-284.
[14] 罗峥, 张蔚, 徐晓云, 史楠, 张燕, 赵梅珍, 刘康永, 赵玫, 李小攀. 65岁以上心脑血管疾病共存病例诊治分析[J]. 中华脑血管病杂志(电子版), 2023, 17(03): 207-213.
[15] 林雨, 王艳玲. 颈动脉斑块易损性的评估与干预的研究进展[J]. 中华脑血管病杂志(电子版), 2023, 17(01): 66-69.
阅读次数
全文


摘要