To investigate the level of interleukin-33 (IL-33) in patients with acute ischemic stroke and its relationship with the clinical prognosis of patients with stroke.

One hundred and ninety-two cases of patients with acute ischemic stroke from Kaiping Central Hospitals and Jiangmen People’s Hospital from January 2017 to June 2019, were selected as the research object, and randomly choose 100 cases of healthy adults as control group, ischemic cerebral apoplexy patients before treatment and after treatment 1^st, 3^rd, 7^th day, and the change of IL-33 healthy adult peripheral blood, and difference, and according to the level of IL-33 patients with cerebral apoplexy from low to high, The differences in the incidence of adverse events of modified Rankin scale (mRs) score and activity of daily living (ADL) score in patients with low level IL-33 (below quartile P25) and high level IL-33 (above quartile P75) at the 3^rd month after treatment were compared. Meanwhile, the predictive value of IL-33 in clinical prognosis of patients with ischemic stroke was analyzed by receiver operating characteristic (ROC) curve.

IL-33 levels in patients with acute ischemic stroke were higher in patients with ischemic stroke, the average on admission was (575.36±200.75)pg/mL, (727.13±204.96)pg/mL at 1^st day after admission, (647.92±228.41)pg/mL at 3^rd day after admission, and (639.02±185.29)pg/mL at 7^th day after admission, while in healthy adults, the average level of IL-33 was (410.32±145.58)pg/mL, these differences between patients with ischemic stroke and healthy adults at different point were statistically significant (P<0.05). The incidence of adverse events in mRs score and ADL score of patients with high IL-33 level was higher than that of patients with low IL-33 level (P<0.05). The area under the ROC curve of IL-33 as a clinical prognostic indicator under the mRs score and ADL score were 0.847 and 0.727, respectively.

The level of IL-33 in peripheral blood of patients with acute ischemic stroke is significantly higher, and has a better predictive value for the prognosis of patients. The higher the level of IL-33 is, the worse the prognosis of patients is.