To investigate the clinical effect of supplementary antiepileptic therapy on electroencephalogram epileptic status in patients with successful resuscitation after cardiac arrest.

Thirty-one patients with status epilepticus after cardiac arrest and obtained successful cardiopulmonary resuscitation (CPR) admitted to Kaiping Central Hospital from January 2016 to December 2018 were selected as the study subjects for a randomized controlled study. According to the random number table method, the patients were divided into the observation group (17 cases) and the control group (14 cases). On the basis of standardized treatment of CPR, the observation group was given supplementary antiepileptic drug therapy to achieve control of epileptic state, while the control group was given conventional sedation treatment. The differences of clinical therapeutic indexes (CPR available time, use of electrical shock, mechanical ventilation, ICU length of hospital stay, recurrence time, epilepsy) and prognosis of neuro-psychiatric outcomes [cerebral performance category (CPC), quality of life assessment scale SF-36 score (SF-36), Montreal cognitive assessment (MoCA), Montgomery and Asberg depression rating scale (MADRS) score] between the two groups were compared.

There were no statistically significant differences in CPR duration, electric defibrillation use, mechanical ventilation duration, and GOS score at discharge time between the two groups (P>0.05). ICU treatment time and epilepsy recurrence rate of patients in the observation group were lower than those in the control group, with statistically significant differences (P<0.05). The average rank of CPC score and MADRS score in the observation group were smaller than those in the control group, with statistically significant differences (P<0.05), while the SF-36 score and MoCA score were higher than those in the control group, with statistically significant differences (P<0.05).

Supplementing antiepileptic therapy can shorten the treatment time in ICU, reduce the rate of epileptic recurrence and effectively improve the neuro-psychiatric prognosis of patients with electroencephalogram epileptic status after resuscitation of cardiac arrest.