Clinical observation of early hyperbaric oxygen in the treatment of traumatic cerebral infarction

doi:10.3877/cma.j.issn.2095-123X.2023.02.005

Abstract

Abstract:

Objective

To observe the clinical effect of early hyperbaric oxygen on traumatic cerebral infarction and analyze its safety.

Methods

From January 2018 to January 2021, a total of 68 patients with combined cerebral infarction and craniocerebral injury were treated in the Neurosurgery Department of the 901^st Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army. According to the treatment method, the patients were divided into two groups. Among them, the control group (32 cases) received routine drug therapy and surgical treatment if necessary after hospitalization, while the treatment group (36 cases) received hyperbaric oxygen therapy after stabilization on the basis of the control group. A course of treatment lasted 10 d. The Fugl-Meyer Assessment (FMA) and the Neurological Deficit Scale (NDS) were used to evaluate the four-limb motor function and neurological deficit degree of patients before and 60 d after treatment. After 180 d of treatment, the modified Rankin scale (mRS) was used to assess the long-term efficacy, and Kaplan-Meier analysis was performed on the two groups of patients.

Results

The FMA score of the two groups at 60 d after treatment was higher than that before treatment, while the NDS score at 60 d after treatment was lower than that before treatment (P<0.05); The FMA score of the treatment group at 60 d after treatment was higher than that of the control group, and the NDS score was lower than that of the control group (P<0.05). After 180 d of treatment, the mRS score of the treatment group was significantly better than that of the control group, and the Kaplan-Meier curve of the treatment group patients was significantly higher than that of the control group patients, with a statistically significant difference (P<0.05). No serious adverse reactions occurred in 2 groups.

Conclusion

Early hyperbaric oxygen therapy can improve the clinical efficacy of traumatic cerebral infarction patients, reduce their mortality, and no serious adverse reactions, worthy of clinical use.

Key words: Traumatic cerebral infarction, Hyperbaric oxygen, Motor function, Neurological deficit, Long-term efficacy

Meijie Zhu, Yulei Liang, Houdong Mei, Kewan Liu, Xiaogang Wu. Clinical observation of early hyperbaric oxygen in the treatment of traumatic cerebral infarction[J]. Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition), 2023, 13(02): 97-101.

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References 16

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组别	例数	性别[例（%）]		年龄（岁，Mean±SD）	梗死位置[例（%）]				GCS评分（分，Mean±SD）
组别	例数	男	女	年龄（岁，Mean±SD）	大脑	小脑	脑干	多发梗死	≤5	6~9	≥10
对照组	32	19（59.38）	13（40.62）	54.3±6.8	20（62.50）	3（9.38）	3（9.38）	6（18.74）	5（15.63）	14（43.75）	13（40.62）
治疗组	36	22（61.11）	14（38.89）	52.4±8.5	24（66.67）	3（8.33）	1（2.78）	8（22.22）	6（16.67）	18（50.00）	12（33.33）
t/χ²值		0.210		0.170	1.419				0.397
P值		0.884		0.986	0.701				0.820

组别	例数	性别[例（%）]		年龄（岁，Mean±SD）	梗死位置[例（%）]				GCS评分（分，Mean±SD）
组别	例数	男	女	年龄（岁，Mean±SD）	大脑	小脑	脑干	多发梗死	≤5	6~9	≥10
对照组	32	19（59.38）	13（40.62）	54.3±6.8	20（62.50）	3（9.38）	3（9.38）	6（18.74）	5（15.63）	14（43.75）	13（40.62）
治疗组	36	22（61.11）	14（38.89）	52.4±8.5	24（66.67）	3（8.33）	1（2.78）	8（22.22）	6（16.67）	18（50.00）	12（33.33）
t/χ²值		0.210		0.170	1.419				0.397
P值		0.884		0.986	0.701				0.820

组别	例数	FMA评分				NDS评分
组别	例数	治疗前	治疗后60 d	t值	P值	治疗前	治疗后60 d	t值	P值
对照组	32	31.97±7.78	48.23±3.37	-9.716	<0.001	32.09±4.47	21.86±3.13	7.213	<0.001
治疗组	36	33.86±9.91	61.42±4.68	-12.298	<0.001	33.46±8.92	12.35±2.81	14.975	<0.001
t值		-0.206	-15.603			-0.398	13.578
P值		0.838	<0.001			0.692	<0.001

组别	例数	FMA评分				NDS评分
组别	例数	治疗前	治疗后60 d	t值	P值	治疗前	治疗后60 d	t值	P值
对照组	32	31.97±7.78	48.23±3.37	-9.716	<0.001	32.09±4.47	21.86±3.13	7.213	<0.001
治疗组	36	33.86±9.91	61.42±4.68	-12.298	<0.001	33.46±8.92	12.35±2.81	14.975	<0.001
t值		-0.206	-15.603			-0.398	13.578
P值		0.838	<0.001			0.692	<0.001

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