Two-year operative effect of deep brain stimulation in Meige syndrome

doi:10.3877/cma.j.issn.2095-123X.2022.06.009

Abstract

Abstract:

Objective

To investigate the improvement of symptoms in recent to two years after bilateral deep brain stimulation (DBS) for Meige syndrome (MS).

Methods

Eleven MS patients were treated from January 2014 to December 2017 in Neurosurgery Department of the Affiliated Drum Tower Hospital of Nanjing University Medical School with bilateral DBS, including 1 case with Stn-DBS and 10 cases with Gpi-DBS. The patients were evaluated by Burke-Fahn-Maisden dystonia rating scale (BFMdrs) before operation, and 1 month, 6 months, 2 years after the pulse stimulator were turned on respectively.

Results

The BFMdrs score of 11 patients before operation was (14.64±1.57), and the scores at 1 month, 6 months, and 2 years after operation were (8.18±1.33), (4.55±1.21), and (4.09±1.22), respectively, with statistical significance compared with that before operation (P<0.05). The average improvement rate at 1 month, 6 months, and 2 years after operation were 44.10%, 68.94%, and 72.05%, respectively.

Conclusion

Bilateral DBS has a definite effect on MS, and the long-term effect is better than the short-term effect, which improves the quality of life of MS patients.

Key words: Meige syndrome, Deep brain stimulation, Motor function, Operative effect

Wu Xu, Chengrong Jiang, Yulong Chong, Weibang Liang. Two-year operative effect of deep brain stimulation in Meige syndrome[J]. Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition), 2022, 12(06): 365-369.

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References 20

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序号	性别	年龄（岁）	病程（年）	分型	靶点	植入设备刺激器	坐标（mm）
序号	性别	年龄（岁）	病程（年）	分型	靶点	植入设备刺激器	电极	X	Y	Z
1	女	45	4	Ⅰ	Gpi	Activa RC	3387	20.5	2	-5
2	女	52	3	Ⅰ	Gpi	Activa RC	3387	21	1	-4
3	男	60	8	Ⅲ	Gpi	Activa RC	3387	22	2	-6
4	女	57	3	Ⅱ	Gpi	Activa RC	3387	19	2	-4
5	男	49	4	Ⅰ	Gpi	Activa RC	3387	20	2	-4
6	男	53	11	Ⅰ	Gpi	Activa RC	3387	19.5	2	-5
7	女	42	6	Ⅲ	Stn	G102R	L301	11	-1	-5
8	女	60	5	Ⅲ	Gpi	Activa RC	3387	20	2	-6
9	女	63	4	Ⅲ	Gpi	G102R	L302	21	1	-4
10	男	52	3	Ⅰ	Gpi	G102R	L302	22	1	-4
11	女	58	7	Ⅰ	Gpi	G102R	L302	18.5	0.5	-4

序号	性别	年龄（岁）	病程（年）	分型	靶点	植入设备刺激器	坐标（mm）
序号	性别	年龄（岁）	病程（年）	分型	靶点	植入设备刺激器	电极	X	Y	Z
1	女	45	4	Ⅰ	Gpi	Activa RC	3387	20.5	2	-5
2	女	52	3	Ⅰ	Gpi	Activa RC	3387	21	1	-4
3	男	60	8	Ⅲ	Gpi	Activa RC	3387	22	2	-6
4	女	57	3	Ⅱ	Gpi	Activa RC	3387	19	2	-4
5	男	49	4	Ⅰ	Gpi	Activa RC	3387	20	2	-4
6	男	53	11	Ⅰ	Gpi	Activa RC	3387	19.5	2	-5
7	女	42	6	Ⅲ	Stn	G102R	L301	11	-1	-5
8	女	60	5	Ⅲ	Gpi	Activa RC	3387	20	2	-6
9	女	63	4	Ⅲ	Gpi	G102R	L302	21	1	-4
10	男	52	3	Ⅰ	Gpi	G102R	L302	22	1	-4
11	女	58	7	Ⅰ	Gpi	G102R	L302	18.5	0.5	-4

序号	术前评分	开机后1个月		开机后6个月		开机后2年
序号	术前评分	评分	改善率	评分	改善率	评分	改善率
1	14	7	50.00%	4	71.83%	3	78.57%
2	13	6	53.85%	5	61.54%	4	69.23%
3	16	9	43.75%	5	68.75%	5	68.75%
4	15	8	46.67%	4	73.33%	3	80.00%
5	13	7	46.15%	3	76.92%	3	76.92%
6	15	9	40.00%	3	80.00%	3	80.00%
7	16	10	37.50%	4	75.00%	4	75.00%
8	17	10	41.18%	4	76.47%	3	82.35%
9	16	9	43.75%	7	56.25%	6	62.50%
10	12	7	41.67%	6	50.00%	6	50.00%
11	14	8	42.86%	5	64.29%	5	64.29%

序号	术前评分	开机后1个月		开机后6个月		开机后2年
序号	术前评分	评分	改善率	评分	改善率	评分	改善率
1	14	7	50.00%	4	71.83%	3	78.57%
2	13	6	53.85%	5	61.54%	4	69.23%
3	16	9	43.75%	5	68.75%	5	68.75%
4	15	8	46.67%	4	73.33%	3	80.00%
5	13	7	46.15%	3	76.92%	3	76.92%
6	15	9	40.00%	3	80.00%	3	80.00%
7	16	10	37.50%	4	75.00%	4	75.00%
8	17	10	41.18%	4	76.47%	3	82.35%
9	16	9	43.75%	7	56.25%	6	62.50%
10	12	7	41.67%	6	50.00%	6	50.00%
11	14	8	42.86%	5	64.29%	5	64.29%

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