Research progress of EEG non-linear analysis in disorders of consciousness

doi:10.3877/cma.j.issn.2095-123X.2023.03.010

Abstract

Abstract:

Disorders of consciousness (DOC) is a serious complication of stroke and other diseases, China's medical system is facing medical and ethical problems brought about by the increasing number of DOC patients. In recent years, the field of coma-arousal medicine has developed rapidly, and the current assessment of DOC patients' consciousness mainly relies on subjective means, such as clinical behavioral scales, but lack of examination methods which is objective and accurate. Electroencephalogram (EEG) non-linear analysis is a novel electrophysiological examination, which combines nonlinear dynamics analysis with EEG. It has the advantages of high temporal resolution, non-invasive, portable and so on. This paper reviews the role of EEG non-linear analysis in evaluating the level of consciousness, the process of recovering from consciousness, prognosis and the efficacy of rehabilitation in patients with DOC after stroke, and provides assistance for the development of multimodal assessment and treatment system of DOC.

Key words: Disorder of consciousness, Stroke, Electroencephalogram, Non-linear dynamics

Xinyu Yang, Jianwen Peng, Huiping Li, Xi Tao, Cuini Fang, Tao Song. Research progress of EEG non-linear analysis in disorders of consciousness[J]. Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition), 2023, 13(03): 185-190.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhnkjbykfzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2095-123X.2023.03.010

https://zhnkjbykfzz.cma-cmc.com.cn/EN/Y2023/V13/I03/185

References 48

[1]	Kondziella D, Bender A, Diserens K, et al. European academy of neurology guideline on the diagnosis of coma and other disorders of consciousness[J]. Eur J Neurol, 2020, 27(5): 741-756. DOI: 10.1111/ene.14151.
[2]	中国残疾人康复协会,中国康复医学会,中国康复研究中心.慢性意识障碍康复中国专家共识[J].中国康复理论与实践, 2023, 29(2): 125-139. DOI: 10.3969/j.issn.1006-9771.2023.02.001.
[3]	何江弘.慢性意识障碍的体系构建[J].中华脑科疾病与康复杂志(电子版), 2018, 8(1): 58-60. DOI: 10.3877/cma.j.issn.2095-123X.2018.01.015.
[4]	陈丹,刘圣香.以家庭为中心的群组式健康管理在缺血性脑卒中病人二级预防中的应用效果[J].护理研究, 2021, 35(3): 514-518. DOI: 10.12102/j.issn.1009-6493.2021.03.032.
[5]	Afrasiabi M, Redinbaugh MJ, Phillips JM, et al. Consciousness depends on integration between parietal cortex, striatum, and thalamus[J]. Cell Syst, 2021, 12(4): 363-373.e311. DOI: 10.1016/j.cels.2021.02.003.
[6]	Towner RA, Saunders D, Smith N, et al. Anti-inflammatory agent, OKN-007, reverses long-term neuroinflammatory responses in a rat encephalopathy model as assessed by multi-parametric MRI: implications for aging-associated neuroinflammation[J]. Geroscience, 2019, 41(4): 483-494. DOI: 10.1007/s11357-019-00094-y.
[7]	中国医师协会神经修复专业委员会意识障碍与促醒学组.慢性意识障碍诊断与治疗中国专家共识[J].中华神经医学杂志, 2020, 19(10): 977-982. DOI: 10.3760/cma.j.cn115354-20200701-00525.
[8]	倪莹莹,王首红,宋为群,等.神经重症康复中国专家共识(中)[J].中国康复医学杂志, 2018, 33(2): 130-136. DOI: 10.3969/j.issn.1001-1242.2018.02.002.
[9]	Van Erp WS, Aben AML, Lavrijsen JCM, et al. Unexpected emergence from the vegetative state: delayed discovery rather than late recovery of consciousness[J]. J Neurol, 2019, 266(12): 3144-3149. DOI: 10.1007/s00415-019-09542-3.
[10]	程晓荣,孙登娟,张义宝,等.重复经颅直流电刺激联合康复治疗意识障碍研究[J].康复学报, 2022, 3(32): 243-247, 253. DOI: 10.3724/SP.J.1329.2022.03007.
[11]	Giacino JT, Katz DI, Schiff ND, et al. Comprehensive systematic review update summary: disorders of consciousness[J]. Arch Phys Med Rehabil, 2018, 99(9): 1710-1719. DOI: 10.1016/j.apmr.2018.07.002.
[12]	陈炎,何艳斌,虞容豪.修订版昏迷恢复量表对长期意识障碍患者的预后评估[J].实用医学杂志, 2019, 35(18): 2905-2908. DOI: 10.3969/j.issn.1006-5725.2019.18.016.
[13]	Zappa S, Fagoni N, Bertoni M, et al. Determination of imminent brain death using the full outline of unresponsiveness score and the glasgow coma scale: a prospective, multicenter, pilot feasibility study[J]. J Intensive Care Med, 2020, 35(2): 203-207. DOI: 10.1177/0885066617738714.
[14]	Zappaterra MW, Lehtinen MK. The cerebrospinal fluid: regulator of neurogenesis, behavior, and beyond[J]. Cell Mol Life Sci, 2012, 69(17): 2863-2878. DOI: 10.1007/s00018-012-0957-x.
[15]	Hollinger A, Rüst CA, Riegger H, et al. Ketamine vs. haloperidol for prevention of cognitive dysfunction and postoperative delirium: a phase IV multicentre randomised placebo-controlled double-blind clinical trial[J]. J Clin Anesth, 2021, 68: 110099. DOI: 10.1016/j.jclinane.2020.110099.
[16]	Mofakham S, Liu Y, Hensley A, et al. Injury to thalamocortical projections following traumatic brain injury results in attractor dynamics for cortical networks[J]. Prog Neurobiol, 2022, 210: 102215. DOI: 10.1016/j.pneurobio.2022.102215.
[17]	Grund M, Forschack N, Nierhaus T, et al. Neural correlates of conscious tactile perception: an analysis of BOLD activation patterns and graph metrics[J]. Neuroimage, 2021, 224: 117384. DOI: 10.1016/j.neuroimage.2020.117384.
[18]	何江弘,谢秋幼,徐如祥.《欧洲昏迷和意识障碍诊断指南》(2020版)解读[J].中华神经创伤外科电子杂志, 2020, 6(3): 135-140. DOI: 10.3877/cma.j.issn.2095-9141.2020.03.002.
[19]	欧梦涵,宋涛.失匹配负波评估意识障碍患者预后的临床应用及研究进展[J].中国康复医学杂志, 2021, 36(5): 616-620. DOI: 10.3969/j.issn.1001-1242.2021.05.021.
[20]	黄丽君,杨新宇,宋涛.事件相关电位P3在慢性意识障碍患者中的临床应用研究[J].中国康复医学杂志, 2022, 37(4): 556-561. DOI: 10.3969/j.issn.1001-1242.2022.04.023.
[21]	高园,史艳妮,柳孟丽,等.急性脑卒中患者轻度认知功能障碍与脑电图变化的相关性及临床分析[J].检验医学与临床, 2020, 17(8): 1097-1100. DOI: 10.3969/j.issn.1672-9455.2020.08.025.
[22]	Jacob JE, Chandrasekharan S, Nair GK, et al. Effect of combining features generated through non-linear analysis and wavelet transform of EEG signals for the diagnosis of encephalopathy[J]. Neurosci Lett, 2021, 765: 136269. DOI: 10.1016/j.neulet.2021.136269.
[23]	Goldberger AL. Non-linear dynamics for clinicians: chaos theory, fractals, and complexity at the bedside[J]. Lancet, 1996, 347(9011): 1312-1314. DOI: 10.1016/s0140-6736(96)90948-4.
[24]	彭静,彭承琳.混沌理论和方法在医学信号处理中的应用[J].国际生物医学工程杂志, 2006, 29(2): 124-127. DOI: 10.3760/cma.j.issn.1673-4181.2006.02.016.
[25]	Sharma AA, Goodman AM, Allendorfer JB, et al. Regional brain atrophy and aberrant cortical folding relate to anxiety and depression in patients with traumatic brain injury and psychogenic nonepileptic seizures[J]. Epilepsia, 2022, 63(1): 222-236. DOI: 10.1111/epi.17109.
[26]	安东侠,李瑶,张文辉,等.记忆力障碍训练对中老年轻、中度认知障碍人群的影响[J].中国老年学杂志, 2021, 41(17): 3697-3700. DOI: 10.3969/j.issn.1005-9202.2021.17.020.
[27]	Alù F, Orticoni A, Judica E, et al. Entropy modulation of electroencephalographic signals in physiological aging[J]. Mech Ageing Dev, 2021, 196: 111472. DOI: 10.1016/j.mad.2021.111472.
[28]	刘义,王文辉,赵武.量化脑电图对于PICU意识障碍患儿应用价值[J].医学理论与实践, 2020, 33(2): 197-200. DOI: 10.19381/j.issn.1001-7585.2020.02.009.
[29]	Sun Y, Chen X. Automatic detection of epilepsy based on entropy feature fusion and convolutional neural network[J]. Oxid Med Cell Longev, 2022, 2022: 1322826. DOI: 10.1155/2022/1322826.
[30]	Lian J, Luo Y, Zheng M, et al. Sleep-dependent anomalous cortical information interaction in patients with depression[J]. Front Neurosci, 2021, 15: 736426. DOI: 10.3389/fnins.2021.736426.
[31]	王勇,梁振虎,夏小雨,等.静息态脑电在意识诊断中的临床应用[J].中国生物医学工程学报, 2021, 40(2): 154-162. DOI: 10.3969/j.issn.0258-8021.2021.02.04.
[32]	Porcaro C, Marino M, Carozzo S, et al. Fractal dimension feature as a signature of severity in disorders of consciousness: an EEG study[J]. Int J Neural Syst, 2022, 32(7): 2250031. DOI: 10.1142/s0129065722500319.
[33]	Luppi AI, Craig MM, Coppola P, et al. Preserved fractal character of structural brain networks is associated with covert consciousness after severe brain injury[J]. Neuroimage Clin, 2021, 30: 102682. DOI: 10.1016/j.nicl.2021.102682.
[34]	Thul A, Lechinger J, Donis J, et al. EEG entropy measures indicate decrease of cortical information processing in disorders of consciousness[J]. Clin Neurophysiol, 2016, 127(2): 1419-1427. DOI: 10.1016/j.clinph.2015.07.039.
[35]	Altıntop ÇG, Latifoğlu F, Akın AK, et al. Classification of depth of coma using complexity measures and nonlinear features of electroencephalogram signals[J]. Int J Neural Syst, 2022, 32(5): 2250018. DOI: 10.1142/s0129065722500186.
[36]	郝学良,杨文伟,李景琦,等.严重意识障碍患者康复过程EEG非线性特征与CRS-R评分相关性分析与可视化表征[J].中国生物医学工程学报, 2015, 34(2): 153-159. DOI: 10.3969/j.issn.0258-8021.2015.02.004.
[37]	Lei L, Liu K, Yang Y, et al. Spatio-temporal analysis of EEG features during consciousness recovery in patients with disorders of consciousness[J]. Clin Neurophysiol, 2022, 133: 135-144. DOI: 10.1016/j.clinph.2021.08.027.
[38]	Lee H, Golkowski D, Jordan D, et al. Relationship of critical dynamics, functional connectivity, and states of consciousness in large-scale human brain networks[J]. Neuroimage, 2019, 188: 228-238. DOI: 10.1016/j.neuroimage.2018.12.011.
[39]	Sarà M, Pistoia F, Pasqualetti P, et al. Functional isolation within the cerebral cortex in the vegetative state: a nonlinear method to predict clinical outcomes[J]. Neurorehabil Neural Repair, 2011, 25(1): 35-42. DOI: 10.1177/1545968310378508.
[40]	Stefan S, Schorr B, Lopez-Rolon A, et al. Consciousness indexing and outcome prediction with resting-state EEG in severe disorders of consciousness[J]. Brain Topogr, 2018, 31(5): 848-862. DOI: 10.1007/s10548-018-0643-x.
[41]	陈璇,蔡贤斌.脑电非线性分析频谱熵对意识障碍患者预后评估的作用[J].广东医学, 2014, 35(11): 1677-1679.
[42]	Gosseries O, Schnakers C, Ledoux D, et al. Automated EEG entropy measurements in coma, vegetative state/unresponsive wakefulness syndrome and minimally conscious state[J]. Funct Neurol, 2011, 26(1): 25-30.
[43]	Wu DY, Cai G, Yuan Y, et al. Application of nonlinear dynamics analysis in assessing unconsciousness: a preliminary study[J]. Clin Neurophysiol, 2011, 122(3): 490-498. DOI: 10.1016/j.clinph.2010.05.036.
[44]	Wu DY, Cai G, Zorowitz RD, et al. Measuring interconnection of the residual cortical functional islands in persistent vegetative state and minimal conscious state with EEG nonlinear analysis[J]. Clin Neurophysiol, 2011, 122(10): 1956-1966. DOI: 10.1016/j.clinph.2011.03.018.
[45]	Liu B, Zhang X, Wang L, et al. Outcome prediction in unresponsive wakefulness syndrome and minimally conscious state by non-linear dynamic analysis of the EEG[J]. Front Neurol, 2021, 12: 510424. DOI: 10.3389/fneur.2021.510424.
[46]	梁振虎,任娜,王勇,等.基于互样本熵脑网络的脊髓电刺激下微意识状态患者脑功能评估[J].中国科学:信息科学, 2021, 51(6): 940-958. DOI: 10.1360/SSI-2020-0010.
[47]	张旭,侯俊,段国平,等.经颅直流电刺激对脑外伤患者精神运动抑制状态的治疗作用[J].中国康复医学杂志, 2018, 33(12): 1405-1409. DOI: 10.3969/j.issn.1001-1242.2018.12.005.
[48]	袁英,汪洁,孙妍,等.经颅直流电刺激对吞咽失用症及皮质兴奋性的作用[J].中国康复医学杂志, 2012, 27(6): 497-503. DOI: 10.3969/j.issn.1001-1242.2012.06.004.

Please choose a citation manager

Content to export