To analyze and summarize the experience of motor cortex electrical stimulation (MCS) in the treatment of central post-stroke pain (CPSP), and to discuss the clinical application of MCS.

Four CPSP patients who were treated with MCS from January 2020 to December 2021 in the Pain Department of the Special Medical Center of the Armed Police Force were selected as the study subjects, and their pain numerical scores (NRS) and pain relief rates were recorded before and 2 weeks, 6 months and 12 months after surgery.

The NRS of 4 patients during the postoperative control stage was 2-3 scores, with 74% remission; After 2-6 months of surgery, NRS scores of 3-5 and 50% remission; After adjusting the stimulation parameters, the pain was relieved again, with the NRS 1-3 scores and 76% remission at 6 to 12 months after surgery. The muscle strength of the limbs of the 4 patients was the same as before, and there were no complications such as subdural effusion, hematomas, hemiplegia, epilepsy, and infection after operation.

MCS is one of the safe and effective methods to treat refractory CPSP patients, which can improve the quality of life of patients. The efficacy of MCS depends on the correct selection of patients, the accurate positioning of electrodes and the optimization of parameters.