To study the effect of growth hormone (GH) combined with enteral nutrition in improving nutritional status and clinical prognosis of coma patients after severe craniocerebral injury.

Eighty-four patients with coma after severe craniocerebral injury from January 1, 2017 to October 31, 2018 were selected as the research object, and they were randomly divided into experimental group and control group, 42 cases, respectively. The experimental group was given the GH with enteral nutrition therapy, and the control group pure use of enteral nutrition, then compared two groups of patients with nutrition related index, including blood biochemical indicator, immune function, complications, and 6 months after discharge life self-care ability assessment rating scale.

The levels of nutrition-related blood biochemical indexes prealbumin, albumin, hemoglobin, transferrin and immune function indexes lgA, lgM and lgG in the experimental group were higher than those in the control group, with statistically significant differences (P<0.05). There was no significant difference between the experimental group and the control group in the incidence of gastrointestinal complications, urinary tract infection and deep vein thrombosis during hospitalization (P>0.05), but the incidence of pulmonary infection in the experimental group was lower than that in the control group during hospitalization (P<0.05). The daily living ability of the experimental group was better than that of the control group at the 6^th month after treatment, and the difference was statistically significant (P<0.05).

GH combined with enteral nutrition can improve the nutritional status of patients with coma after severe craniocerebral injury, reduce the incidence of complications and improve the long-term clinical prognosis.