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中华脑科疾病与康复杂志(电子版)

中华脑科疾病与康复杂志(电子版) ›› 2017, Vol. 07 ›› Issue (01) : 10 -12. doi: 10.3877/cma.j.issn.2095-123X.2017.01.003

所属专题： 总编推荐； 文献；

临床研究

血清S100β蛋白在孤立性眩晕患者的表达及意义
魏丹1,†(), 李彤2, 杨玉峰1, 张殿印1, 李国平1, 李建波1, 侯玉芹1   
  1. 1. 455000　河南安阳，安阳地区医院神经内科
    2. 453100　河南卫辉，新乡医学院第一附属医院神经内科
  • 收稿日期:2016-07-04 出版日期:2017-02-01
  • 通信作者: 魏丹

Expression and clinical significance of serum protein S100β in patients with isolated vertigo

Dan Wei1,†(), Tong Li2, Yufeng Yang1, Dianyin Zhang1, Guoping Li1, Jianbo Li1, Yuqin Hou1   

  1. 1. Department of Neurology, Anyang Regional Hospital, Anyang 455000 China
    2. Department of Neurology, the First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, China
  • Received:2016-07-04 Published:2017-02-01
  • Corresponding author: Dan Wei
  • About author:
    Corresponding author: Wei Dan, Email:
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魏丹, 李彤, 杨玉峰, 张殿印, 李国平, 李建波, 侯玉芹. 血清S100β蛋白在孤立性眩晕患者的表达及意义[J]. 中华脑科疾病与康复杂志(电子版), 2017, 07(01): 10-12.

Dan Wei, Tong Li, Yufeng Yang, Dianyin Zhang, Guoping Li, Jianbo Li, Yuqin Hou. Expression and clinical significance of serum protein S100β in patients with isolated vertigo[J]. Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition), 2017, 07(01): 10-12.

目的

探索血清S100β蛋白在孤立性眩晕患者的表达，分析其在发病早期对急性后循环卒中与非血管性眩晕的鉴别，为临床孤立性眩晕患者的早期诊断和治疗提供可靠依据。

方法

以急性孤立性眩晕起病的患者为研究对象，分为卒中组(50例)和非血管性眩晕组(50例)，分别测定其在发病24小时内的空腹血清S100β蛋白浓度。

结果

卒中组血清S100β蛋白浓度显著高于非血管性眩晕组，差异具有统计学意义(t＝6.456，P＝0.000)。

结论

S100β蛋白可以作为一种血清生物学标记来鉴别以孤立性眩晕起病的急性后循环卒中和非血管性眩晕。

关键词: 孤立性眩晕, 急性后循环卒中, S100β蛋白
Objective

To investigate the expression of serum protein S100β in patients with isolated vertigo, analyze the diagnosis effect on acute posterior circulation stroke and nonvascular vertigo, which provide the evidence for early diagnosis and treatment of isolated vertigo.

Methods

The patients with acute isolated vertigo were divided into two groups, the stroke group (50 cases) and the nonvascular vertigo group (50 cases), and the empty serum protein S100β expression levels in 24 hours was tested .

Results

The levels of serum protein S100β in the stroke group were significantly higher than the nonvascular vertigo group, with a statistical difference (t=6.456, P=0.000 ).

Conclusion

S100β could serve as a biomarker for distinguishing between acute posterior circulation stroke and nonvascular vertigo.

Key words: Isolated vertigo, Acute posterior circulation stroke, S100β
表1 两组患者一般情况比较
组别 年龄(岁，±s) 性别(n)
男 女
卒中组 59.200±12.381 32 18
非血管性眩晕组 58.100±10.257 22 28
统计值 t＝20.848 χ2＝24.02
P值 0.407 0.45
表2 两组患者空腹血清S100β蛋白的表达(ng/ml，±s)
组别 n S100β
卒中组 50 0.657±0.070
非血管性眩晕组 50 0.471±0.058
t ? 6.456
P ? 0.000
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