进展性脑梗死患者血清CTRP3的表达及其与炎症因子的相关性

doi:10.3877/cma.j.issn.2095-123X.2019.02.006

中华脑科疾病与康复杂志(电子版) ›› 2019, Vol. 09 ›› Issue (02) : 87 -90. doi: 10.3877/cma.j.issn.2095-123X.2019.02.006

所属专题：文献；

临床研究

进展性脑梗死患者血清CTRP3的表达及其与炎症因子的相关性

李柏林¹, 梁春娜¹, 谭文静¹, 阮炎鹏², 梁明俊¹, 谢富华³^,^†(

)

^1. 529300　江门，开平市中心医院急诊科
^2. 529300　江门，开平市中心医院神经内科
^3. 510000　广州，广州医科大学附属第二医院重症医学科

收稿日期:2019-03-11 出版日期:2019-04-15
通信作者: 谢富华

Expression of serum CTRP3 in patients with progressive cerebral infarction and its correlation with inflammatory factors

Bolin Li¹, Chunna Liang¹, Wenjing Tan¹, Yanpeng Ruan², Mingjun Liang¹, Fuhua Xie³^,^†()

^1. Department of Emergency, Kaiping Central Hospital, Jiangmen 529300, China
^2. Department of Neurology, Kaiping Central Hospital, Jiangmen 529300, China
^3. Department of Critical Care Medicine, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510000, China

Received:2019-03-11 Published:2019-04-15
Corresponding author: Fuhua Xie
About author:
Corresponding author: Xie Fuhua, Email: sddermhgw@163.com

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目的

观察进展性脑梗死（PCI）患者血清C1q/TNF相关蛋白3（CTRP3）的变化水平并探讨其临床价值。

方法

选择开平市中心医院神经内科自2017年3月至2018年3月收治的PCI患者55例为研究组，55例健康体检者为对照组。酶联免疫吸附法（ELISA）检测研究组和对照组患者治疗前后肿瘤坏死因子α（TNF-α）、白细胞介素6（IL-6）和CTRP3的水平。

结果

治疗前研究组血清TNF-α、IL-6水平高于对照组（P<0.05），CTRP3水平低于对照组（P<0.05），CTRP3与TNF-α、IL-6水平呈负相关（r=-0.351，P=0.009；r=-0.465，P=0.003）。治疗后研究组TNF-α、IL-6水平较治疗前均降低，CTRP3水平增高，差异具有统计学意义（P<0.05），CTRP3与TNF-α、IL-6水平也呈负相关（r=-0.326，P=0.015；r=-0.569，P=0.001）。

结论

PCI患者血清CTRP3含量显著降低，治疗后水平增高，且与TNF-α、IL-6水平负相关，提示CTRP3可能参与PCI后脑损伤的病理生理过程，CTRP3的表达可能作为辅助判断PCI病情进展的一项指标。

关键词: C1q/TNF相关蛋白3, 进展性脑梗死, 肿瘤坏死因子α, 白细胞介素6

Objective

To observe the changes of serum C1q/TNF-related protein 3 (CTRP3) in patients with progressive cerebral infarction (PCI) and to explore its clinical value.

Methods

Fifty-five patients with PCI were selected as the research group, fifty-five healthy subjects were selected as the control group. The levels of tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6) and CTRP3 were compared between the two groups before and after treatment by enzyme-linked immunosorbent assay (ELISA).

Results

The levels of TNF-α and IL-6 in research group were higher than those in control group (P<0.05). The level of CTRP3 in the research group was lower than that in control group (P<0.05). CTRP3 has a negative correlation between TNF-α and IL-6 levels (r=-0.351, P=0.009; r=-0.465, P=0.003), respectively. After treatment, the levels of TNF-α and IL-6 in PCI group were decreased, and the level of CTRP3 was increased (P<0.05), CTRP3 has a negative correlation between TNF-α and IL-6 levels (r=-0.326, P=0.015; r=-0.569, P=0.001), respectively.

Conclusion

The level of serum CTRP3 in patients with PCI was decreased, and CTRP3 levels was increased after treatment, and it is negatively correlated with the levels of TNF-α and IL-6. It is suggested that CTRP3 may be involved in the pathophysiological process of brain injury after PCI. The detection of serum CTRP3 may have important clinical significance in assisting to judge the prognosis of PCI.

Key words: C1q/TNF-related protein 3, Progressive cerebral infarction, Tumor necrosis factor α, Interleukin-6

表1 2组受试者治疗前血清TNF-α、IL-6和CTRP3表达水平比较

组别	例数	TNF-α（pg/mL）	IL-6（pg/mL）	CTRP3（ng/mL）
研究组	55	102.60±19.85	114.7±26.22	129.65±53.21
对照组	55	9.70±2.34	21.44±4.99	326.50±61.06
t值	?	34.470	25.877	18.032
P值	?	0.001	0.001	0.001

表1 2组受试者治疗前血清TNF-α、IL-6和CTRP3表达水平比较

组别	例数	TNF-α（pg/mL）	IL-6（pg/mL）	CTRP3（ng/mL）
研究组	55	102.60±19.85	114.7±26.22	129.65±53.21
对照组	55	9.70±2.34	21.44±4.99	326.50±61.06
t值	?	34.470	25.877	18.032
P值	?	0.001	0.001	0.001

表2 研究组患者治疗前后血清TNF-α、IL-6和CTRP3表达水平比较

组别	例数	TNF-α（pg/mL）	IL-6（pg/mL）	CTRP3（ng/mL）
治疗前	55	102.60±19.85	114.57±26.22	129.65±53.21
治疗后	55	20.95±6.00	39.74±9.30	258.40±66.17
t值	?	29.206	19.946	11.244
P值	?	0.001	0.001	0.001

表2 研究组患者治疗前后血清TNF-α、IL-6和CTRP3表达水平比较

组别	例数	TNF-α（pg/mL）	IL-6（pg/mL）	CTRP3（ng/mL）
治疗前	55	102.60±19.85	114.57±26.22	129.65±53.21
治疗后	55	20.95±6.00	39.74±9.30	258.40±66.17
t值	?	29.206	19.946	11.244
P值	?	0.001	0.001	0.001

图1 PCI患者治疗前后血清TNF-α、IL-6和CTRP3表达的相关性

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Expression of serum CTRP3 in patients with progressive cerebral infarction and its correlation with inflammatory factors

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Expression of serum CTRP3 in patients with progressive cerebral infarction and its correlation with inflammatory factors