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中华脑科疾病与康复杂志(电子版) ›› 2019, Vol. 09 ›› Issue (02) : 117 -120. doi: 10.3877/cma.j.issn.2095-123X.2019.02.013

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综述

高同型半胱氨酸血症的发生机制及其病理生理学意义
王淑珍1, 王洪生2, 王立志3, 李英杰1,()   
  1. 1. 075000 张家口,陆军第八十一集团军医院神经内科
    2. 075000 张家口,陆军第八十一集团军医院神经外科
    3. 075000 张家口,陆军第八十一集团军医院干部病房科
  • 收稿日期:2019-03-05 出版日期:2019-04-15
  • 通信作者: 李英杰

Mechanism of hyperhomocysteinemia and its pathological significance

Shuzhen Wang1, Hongsheng Wang2, Lizhi Wang3, Yingjie Li1,()   

  1. 1. Department of Neurology, The 81 Group Military Hospital of PLA, 075000 Zhangjiakou, China
    2. Department of Neurosurgery, The 81 Group Military Hospital of PLA, Zhangjiakou 075000, China
    3. Department of Cadre Ward, The 81 Group Military Hospital of PLA, Zhangjiakou 075000, China
  • Received:2019-03-05 Published:2019-04-15
  • Corresponding author: Yingjie Li
  • About author:
    Corresponding author: Li Yingjie, Email:
引用本文:

王淑珍, 王洪生, 王立志, 李英杰. 高同型半胱氨酸血症的发生机制及其病理生理学意义[J]. 中华脑科疾病与康复杂志(电子版), 2019, 09(02): 117-120.

Shuzhen Wang, Hongsheng Wang, Lizhi Wang, Yingjie Li. Mechanism of hyperhomocysteinemia and its pathological significance[J]. Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition), 2019, 09(02): 117-120.

在过去的10年中,同型半胱氨酸(Hcy)被认为是心血管病及许多其他疾病明确的危险因素。Hcy由蛋氨酸通过多种步骤生物合成而来,再通过甲基化和转硫基途径重新生成蛋氨酸。高同型半胱氨酸血症(HHcy)是机体内Hcy过高的一种状态,其主要原因是Hcy代谢过程中相关的酶缺陷及辅助因子缺乏,其他原因包括蛋氨酸摄取过量、一些疾病影响及药物的副作用。HHcy是许多疾病如动脉粥样硬化、充血性心力衰竭、年龄相关性黄斑变性、阿尔茨海默病、听力丧失的触发因素。Hcy水平增高是许多疾病的独立原因或加重因素,但其因果关系尚未完全清楚。

In the last 10 years, homocysteine (Hcy) has been regarded as a marker of cardiovascular disease and a definite risk factor for many other diseases. Hcy is biosynthesized from methionine through multiple steps and then goes through one of two major metabolic pathways: remethylation and transsulfuration. Hyperhomocysteinemia (HHcy) is a state in which too much Hcy is present in the body. The main cause of HHcy is a dysfunction of enzymes and cofactors associated with the process of Hcy biosynthesis. Other causes include excessive methionine intake, certain diseases and side effects of some drugs. HHcy is a trigger for many diseases, such as atherosclerosis, congestive heart failure, age-related macular degeneration, Alzheimer’s disease and hearing loss. There are many studies showing a positive relationship between Hcy level and various symptoms. We speculate that a high level of Hcy can be the sole reason or an aggravating factor in numerous diseases for which causal links are not fully understood.

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