切换至 "中华医学电子期刊资源库"

中华脑科疾病与康复杂志(电子版) ›› 2021, Vol. 11 ›› Issue (06) : 349 -352. doi: 10.3877/cma.j.issn.2095-123X.2021.06.006

临床研究

剪切波弹性成像技术检测颈动脉斑块不同位置杨氏模量在颈动脉内膜剥脱术前、后一致性的对比研究
张红伟1, 林爱龙2,(), 王志涛1, 余志鹄1, 郭愿1, 刘建新3   
  1. 1. 430033 武汉,江汉大学附属湖北省第三人民医院超声影像科
    2. 430033 武汉,江汉大学附属湖北省第三人民医院神经外科
    3. 430031 武汉,华中科技大学同济医学院附属武汉市中心医院超声影像科
  • 收稿日期:2021-09-16 出版日期:2021-12-15
  • 通信作者: 林爱龙
  • 基金资助:
    湖北省卫生健康委员会科研项目(WJ2019F175)

Shear wave elastography was used to detect Young’s modulus at different locations of carotid plaques before and after carotid endarterectomy contrastive study of pathogenicity

Hongwei Zhang1, Ailong Lin2,(), Zhitao Wang1, Zhihu Yu1, Yuan Guo1, Jianxin Liu3   

  1. 1. Department of Ultrasound, The Third People’s Hospital of Hubei Province Affiliated to Jianghan University, Wuhan 430033, China
    2. Department of Neurosurgery, The Third People’s Hospital of Hubei Province Affiliated to Jianghan University, Wuhan 430033, China
    3. Department of Ultrasound and Neurosurgery, Wuhan Central Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430031, China
  • Received:2021-09-16 Published:2021-12-15
  • Corresponding author: Ailong Lin
引用本文:

张红伟, 林爱龙, 王志涛, 余志鹄, 郭愿, 刘建新. 剪切波弹性成像技术检测颈动脉斑块不同位置杨氏模量在颈动脉内膜剥脱术前、后一致性的对比研究[J]. 中华脑科疾病与康复杂志(电子版), 2021, 11(06): 349-352.

Hongwei Zhang, Ailong Lin, Zhitao Wang, Zhihu Yu, Yuan Guo, Jianxin Liu. Shear wave elastography was used to detect Young’s modulus at different locations of carotid plaques before and after carotid endarterectomy contrastive study of pathogenicity[J]. Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition), 2021, 11(06): 349-352.

目的

探究颈动脉斑块顶部、基底部不同位置的杨氏模量测值在颈动脉内膜剥脱术(CEA)前、后的一致性对比的差异性。

方法

选取江汉大学附属湖北省第三人民医院神经外科自2019年1月至2021年8月行CEA术所取的23例斑块标本为研究对象,采用剪切波弹性成像技术检测分析术前、术后该斑块不同部位杨氏模量数值及分布情况,查看一致性,分析原因。

结果

23例斑块标本在术前测量杨氏模量值(E)顶部16.284(14.221,18.623) kPa,基底部35.982(31.332,42.351) kPa;术后24 h内测量杨氏模量值(E)顶部为18.132(15.610,20.345) kPa,基底部为40.223(34.680,46.731) kPa,差异均具有统计学意义(P=0.018,0.011)。

结论

颈动脉斑块CEA术前、术后不同位置杨氏模量测值没有一致性,规范测量和评估其平均E值可靠并且具有一定的参考价值。

Objective

To explore whether there is difference in consistency between Young’s modulus measured at different positions of carotid plaque at the top and base before and after carotid endarterectomy (CEA).

Methods

The plaque specimens collected from 23 cases of CEA in the Neurosurgery Department of The Third People’s Hospital of Hubei Province Affiliated to Jianghan University from January 2019 to August 2021 were detected and analyzed by shear-wave elastic imaging technology for the value and distribution of Young’s modulus in different parts of the plaque before and after surgery, to check the consistency and analyze the reasons for consistency or inconsistency.

Results

Preoperative measurement of Young’s modulus (E) was 16.284 (14.221, 18.623) kPa at the top and 35.982 (31.332, 42.351) kPa at the base of 23 plaque specimens. Young’s modulus (E) was 18.132 (15.610, 20.345) kPa at the top and 40.223 (34.680, 46.731) kPa at the base after surgery within 24 h (P=0.018, 0.011).

Conclusion

Young’s modulus measured at different positions of cervical plaque pulse before and after CEA is not consistent. The standardized measurement and evaluation of its average E value are reliable and have certain reference value.

图3 的颈动脉斑块术后23例标本的顶部及基底部E值散点图
表1 23例斑块标本在CEA术前、术后不同位置平均E值分布情况
[1]
Meairs S, Hennerici M. Four-dimensional ultrasonographic characterization of plaque surface motion in patients with symptomatic and asymptomatic carotid artery stenosis[J]. Stroke, 1999, 30(9): 1807-1813.
[2]
Hood DB, Mattos MA, Mansour A, et al. Prospective evaluation of new duplex criteria to identify 70% internal carotid artery stenosis[J]. J Vasc Surg, 1996, 23(2): 254-261; discussion 261-262.
[3]
王陇德. 中国脑卒中防治报告[M]. 北京: 北京人民卫生出版社,2017.
[4]
Lovett JK, Gallagher PJ, Hands LJ, et al. Histological correlates of carotid plaque surface morphology on lumen contrast imaging[J]. Circulation, 2004, 110(15): 2190-2197.
[5]
Fukuda K, Iihara K, Maruyama D, et al. Relationship between carotid artery remodeling and plaque vulnerability with T1-weighted magnetic resonance imaging[J]. J Stroke Cerebrovasc Dis, 2014, 23(6): 1462-1470.
[6]
王艳红,钱林学,胡向东, 等. 剪切波弹性成像技术评估颈动脉斑块硬度[J]. 临床和实验医学杂志, 2015, 14(4): 327-330.
[7]
杨莉红,成英,孙月, 等. 实时剪切波超声弹性成像技术评价兔腹主动脉粥样硬化斑块易损性的实验研究[J]. 中国超声医学杂志, 2018, 34(5): 460-462.
[8]
贾慧霞,金蓉. 颈动脉粥样硬化斑块影像学诊断方法的研究进展[J]. 国际生物医学工程杂志, 2015, 38(3): 183-186.
[9]
张俊华,于明,苏建华, 等. 瑞舒伐他汀对脑梗死合并颈动脉粥样硬化患者神经功能缺损及血清炎性因子水平的影响[J]. 临床神经病学杂志, 2014, 27(3): 196-198.
[10]
Ophir J, Céspedes I, Ponnekanti H, et al. Elastography: a quantitative method for imaging the elasticity of biological tissues[J]. Ultrason Imaging, 1991, 13(2): 111-134.
[11]
Tanter M, Bercoff J, Athanasiou A, et al. Quantitative assessment of breast lesion viscoelasticity: initial clinical results using supersonic shear imaging[J]. Ultrasound Med Biol, 2008, 34(9): 1373-1386.
[12]
Athanasiou A, Tardivon A, Tanter M, et al. Breast lesions: quantitative elastography with supersonic shear imaging--preliminary results[J]. Radiology, 2010, 256(1): 297-303.
[13]
樊荣,冯建钦,郭倩倩, 等. 剪切波弹性成像用于动脉粥样斑块组织成分定征及易损性评价的实验研究[J]. 中华超声影像学杂志, 2015, 24(5): 429-434.
[14]
王立娟,勇强,包晶晶, 等. 应用剪切波技术测量模块弹性值符合度的试验研究[J]. 中国超声医学杂志, 2018, 34(7): 655-659.
[15]
Sevuk U, Bahadir MV, Altindag R, et al. Relationship between thyroid function and carotid artery plaque ulceration[J]. Acta Neurol Belg, 2015, 115(4): 581-587.
[16]
段依恋,项飞翔,曹海燕, 等. 剪切波弹性成像检测脑梗死患者颈动脉粥样斑块的易损性[J]. 临床超声医学杂志, 2017, 19(9): 614-616.
[1] 吕琦, 惠品晶, 丁亚芳, 颜燕红. 颈动脉斑块易损性的超声造影评估及与缺血性卒中的相关性研究[J]. 中华医学超声杂志(电子版), 2023, 20(10): 1040-1045.
[2] 张莲莲, 惠品晶, 丁亚芳. 颈部血管超声在粥样硬化斑块易损性评估中的应用价值[J]. 中华医学超声杂志(电子版), 2023, 20(08): 816-821.
[3] 王珏, 陈赛君, 贲志飞, 詹锦勇, 徐开颖. 剪切波弹性成像联合极速脉搏波技术评估颈动脉弹性对糖尿病性视网膜病变的预测价值[J]. 中华医学超声杂志(电子版), 2023, 20(06): 636-641.
[4] 黄珈瑶, 林满霞, 田文硕, 何璟怡, 赖佳明, 谢晓燕, 龙海怡. 健康成人胰腺剪切波弹性成像的可行性和测量值及其影响因素[J]. 中华医学超声杂志(电子版), 2023, 20(05): 524-529.
[5] 郭云云, 解翔, 彭梅, 姜凡, 毕玉, 何年安, 胡蕾, 杨杨, 王涛, 石玉洁, 陈冬冬. ACR-TIRADS与C-TIRADS分类分别联合二维剪切波弹性成像对甲状腺结节分类的诊断效能——多中心回顾性研究[J]. 中华医学超声杂志(电子版), 2023, 20(05): 511-516.
[6] 程广文, 丁红, 陈坤, 张祯, 黄翀, 张继明. 实时双幅联合弹性成像在慢性肝病肝纤维化与炎症分层诊断中的价值[J]. 中华医学超声杂志(电子版), 2023, 20(01): 63-69.
[7] 壮健, 潘昌杰, 李晓琴, 于梦霞, 张超, 朱韦文. 剪切波弹性成像技术评估子痫前期胎盘弹性的临床价值[J]. 中华医学超声杂志(电子版), 2022, 19(07): 660-666.
[8] 唐远姣, 刘伊铃, 郭瑞倩, 钟琳, 邱逦. 健康人群四肢近端肌肉剪切波弹性成像测量的初步研究[J]. 中华医学超声杂志(电子版), 2022, 19(06): 541-547.
[9] 强坤坤, 罗红. 杜氏肌营养不良症患儿的高频超声与剪切波弹性成像诊断研究现状及前景[J]. 中华妇幼临床医学杂志(电子版), 2023, 19(02): 162-167.
[10] 冯佳佳, 刘丹, 张广炜, 金丽霞. microRNA与脑动脉粥样硬化斑块破裂的研究新进展[J]. 中华临床医师杂志(电子版), 2022, 16(06): 601-604.
[11] 何慧灵, 张宣宣, 张兰, 吴晓瑾, 姜美娟, 陈剑. 乳腺周边组织进行剪切波弹性成像诊断结节良恶性的价值研究[J]. 中华临床医师杂志(电子版), 2022, 16(04): 319-325.
[12] 熊鑫, 邓勇志. 基于血管内超声的机器学习在冠状动脉病变中的研究进展[J]. 中华诊断学电子杂志, 2023, 11(03): 153-157.
[13] 林雨, 王艳玲. 颈动脉斑块易损性的评估与干预的研究进展[J]. 中华脑血管病杂志(电子版), 2023, 17(01): 66-69.
[14] 白艳, 董秋梅, 王雄耀. 颈动脉粥样硬化性缺血性卒中风险评估的研究进展[J]. 中华脑血管病杂志(电子版), 2022, 16(06): 439-442.
[15] 朱欣伟, 李俊林, 张建平, 包金岗, 吴日乐. 颈动脉斑块内出血影像学检查的应用进展[J]. 中华脑血管病杂志(电子版), 2022, 16(06): 427-431.
阅读次数
全文


摘要