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中华脑科疾病与康复杂志(电子版) ›› 2025, Vol. 15 ›› Issue (01) : 10 -14. doi: 10.3877/cma.j.issn.2095-123X.2025.01.002

指南解读

2024年《脑瘫和肌张力障碍的药物和神经外科治疗:临床实践指南更新》解读
康贝贝1, 余强1, 徐磊2, 陈蓉1, 王柳1, 曹建国3,()   
  1. 1. 518038 深圳市福田区妇幼保健院儿童保健科
    2. 518038 深圳市福田区妇幼保健院儿童心理与康复科
    3. 518038 深圳市儿童医院康复科
  • 收稿日期:2024-11-01 出版日期:2025-02-15
  • 通信作者: 曹建国
  • 基金资助:
    深圳市福田区卫生健康系统科研项目(FTWS080)广东省高水平医院建设经费深圳市儿童医院临床研究专项(LCYJ2022084)

Interpretation on 2024 “Pharmacological and neurosurgical management of cerebral palsy and dystonia: Clinical practice guideline update”

Beibei Kang1, Qiang Yu1, Lei Xu2, Rong Chen1, Liu Wang1, Jianguo Cao3,()   

  1. 1. Department of Child Health Care, Futian District Maternal and Child Health Hospital, Shenzhen 518038, China
    2. Department of Child Neurological Rehabilitation, Shenzhen Maternal and Child Health Hospital, Shenzhen 518038, China
    3. Department of Rehabilitation, Shenzhen Children's Hospital, Shenzhen 518038, China
  • Received:2024-11-01 Published:2025-02-15
  • Corresponding author: Jianguo Cao
引用本文:

康贝贝, 余强, 徐磊, 陈蓉, 王柳, 曹建国. 2024年《脑瘫和肌张力障碍的药物和神经外科治疗:临床实践指南更新》解读[J/OL]. 中华脑科疾病与康复杂志(电子版), 2025, 15(01): 10-14.

Beibei Kang, Qiang Yu, Lei Xu, Rong Chen, Liu Wang, Jianguo Cao. Interpretation on 2024 “Pharmacological and neurosurgical management of cerebral palsy and dystonia: Clinical practice guideline update”[J/OL]. Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition), 2025, 15(01): 10-14.

肌张力障碍的典型特征包括缓慢的不自主运动、姿势异常和肌张力波动,常见于脑瘫儿童,对运动功能、疼痛、睡眠、家庭照护等方面有很大影响,因其病因复杂,目前尚无特效治疗方法。药物及神经外科干预是改善肌张力障碍的重要治疗方法,但其循证依据有限,缺乏临床应用规范。2024年3月,来自6个国家的10个研究中心组成的国际专家小组发布了《脑瘫和肌张力障碍的药物和神经外科治疗:临床实践指南更新》,对2018年发表的干预建议进行了更新和补充,提出了针对脑瘫和肌张力障碍患者使用药物治疗和神经外科干预的10条循证建议,以指导临床应用决策。本文结合我国肌张力障碍诊疗专家共识对该指南的重点内容进行解读,以期为我国脑瘫及肌张力障碍的治疗提供指导和参考。

The typical characteristics of dystonia are slow involuntary movements, abnormal postures, and muscle tone fluctuations, which are common in children with cerebral palsy and have a significant impact on motor function, pain, sleep, and home care. Due to its complex etiology, there is currently no specific treatment method available. Drug and neurosurgical interventions are important treatment methods for improving muscle tone disorders, but their evidence-based basis is limited and lacks clinical application standards. In March 2024, an international expert group consisting of 10 research centers from 6 countries released the “Pharmacological and neurosurgical management of cerebral palsy and dystonia: Clinical practice guideline update”, which updated and supplemented the intervention recommendations published in 2018. It proposed 10 evidence-based recommendations for drug treatment and neurosurgical intervention in patients with cerebral palsy and Muscular Dysfunction to guide clinical application decision-making. This article interprets the key content of this guideline in conjunction with the consensus of Chinese experts in the diagnosis and treatment of muscle tone disorders, in order to provide guidance and reference for the treatment of cerebral palsy and muscle tone disorders in China.

图1 肌张力障碍的临床路径
Fig.1 The care pathway of dystonia
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