切换至 "中华医学电子期刊资源库"

中华脑科疾病与康复杂志(电子版) ›› 2025, Vol. 15 ›› Issue (01) : 26 -30. doi: 10.3877/cma.j.issn.2095-123X.2025.01.005

临床研究

神经内镜微创手术治疗高血压脑出血的临床效果分析
曾坚锋1, 李钢1,(), 刘成业1, 王辉1   
  1. 1. 572000 三亚,三亚中心医院神经外科
  • 收稿日期:2024-10-14 出版日期:2025-02-15
  • 通信作者: 李钢

Effect analysis of minimally invasive neuroendoscopic surgery in patients with hypertensive intracerebral hemorrhage

Jianfeng Zeng1, Gang Li1,(), Chengye Liu1, Hui Wang1   

  1. 1. Department of Neurosurgery, Sanya Central Hospital, Sanya 572000, China
  • Received:2024-10-14 Published:2025-02-15
  • Corresponding author: Gang Li
引用本文:

曾坚锋, 李钢, 刘成业, 王辉. 神经内镜微创手术治疗高血压脑出血的临床效果分析[J/OL]. 中华脑科疾病与康复杂志(电子版), 2025, 15(01): 26-30.

Jianfeng Zeng, Gang Li, Chengye Liu, Hui Wang. Effect analysis of minimally invasive neuroendoscopic surgery in patients with hypertensive intracerebral hemorrhage[J/OL]. Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition), 2025, 15(01): 26-30.

目的

探讨神经内镜微创手术治疗高血压脑出血(HICH)的效果。

方法

选取三亚中心医院神经外科自2022年1月至2023年12月行手术治疗的60例HICH患者进行回顾性分析,按照术式不同将其分为对照组和观察组,每组30例。对照组行小骨窗开颅血肿清除术,观察组行神经内镜下血肿清除术。比较2组患者的围术期指标,术后7 d和2个月的神经功能[美国国立卫生研究院卒中量表(NIHSS)]、生活自理能力[改良Barthel指数(MBI)],以及预后(GOS评分)和并发症发生情况。

结果

观察组患者的血肿清除率更高,围术期指标均优于对照组,差异有统计学意义(P<0.05)。术后2个月时,观察组预后良好率、MBI评分高于对照组,NIHSS评分、并发症发生率低于对照组,差异均有统计学意义(P<0.05)。

结论

神经内镜微创手术可提高HICH的血肿清除率,强化神经功能缺损的修复效果,改善患者的预后,且安全性优于传统的开颅手术。

Objective

To investigate the effects of minimally invasive neuroendoscopic surgery on hypertensive intracerebral hemorrhage (HICH).

Methods

Sixty patients with HICH who underwent surgical treatment in the Neurosurgery Department of Sanya Central Hospital from January 2022 to December 2023 were selected for retrospective analysis and divided into control group and observation group according to different operation methods, with 30 cases in each group. The control group received small bone window craniotomy for hematoma removal, and the observation group received neuroendoscopic hematoma removal. The perioperative indexes, the degree of neurological impairment[National Institute of Health stroke scale (NIHSS)], self-care ability [modified Barthel index (MBI)],prognosis (GOS score) and the incidence of complications were compared between the two groups.

Results

The hematomas clearance rate of the observation group was higher, and perioperative indexes were better than those of the control group, with statistical significance (P<0.05). At 2 months after surgery, the good prognosis rate and MBI score of the observation group were higher than those of the control group, and the NIHSS score and complication rate were lower than those of the control group, with statistical significance (P<0.05).

Conclusion

Minimally invasive neuroendoscopic surgery can improve the hematoma clearance rate of HICH, strengthen the repair effect of nerve function defect, improve the prognosis of patients, and is safer than traditional craniotomy.

表1 2组患者的围术期指标比较(Mean±SD
Tab.1 Comparison of perioperative indexes between two groups(Mean±SD
表2 2组患者术后不同时间段NIHSS和MBI评分比较(分,Mean±SD
Tab.2 Comparison of NIHSS and MBI scores in different time periods between two groups (score,Mean±SD
表3 2组患者术后2个月GOS评分比较[例(%)]
Tab.3 Comparison of GOS scores between two groups 2 months after surgery [n(%)]
表4 2组患者的并发症发生率比较[例(%)]
Tab.4 Comparison of complication rates between two groups[n(%)]
[1]
刁正文, 徐愈畅, 张杰, 等. β-七叶皂苷钠联合甘油果糖治疗脑出血的临床效果分析[J]. 中华神经创伤外科电子杂志, 2023, 9(1): 32-37. DOI: 10.3877/cma.j.issn.2095-9141.2023.01.006.Diao ZW, Xu YC, Zhang J, et al. Clinical analysis of β-aescinate sodium combined with glycerin fructose in the treatment of cerebral hemorrhage[J]. Chin J Neurotrauma Surg (Electronic Edition), 2023, 9(1): 32-37. DOI: 10.3877/cma.j.issn.2095-9141.2023.01.006.
[2]
吴毅, 王中勇, 朱卿, 等. 基底节区高血压脑出血患者血压控制水平、长时血压变异性及血清IL-6对早期认知障碍的影响[J].中华神经医学杂志, 2024, 23(8): 769-776. DOI: 10.3760/cma.j.cn115354-20240612-00341.Wu Y, Wang ZY, Zhu Q, et al. Influences of blood pressure control, long-term blood pressure variability and serum IL-6 in early cognitive impairment in patients with basal ganglia hypertensive intracerebral hemorrhage[J]. Chin J Neuromed,2024, 23(8): 769-776. DOI: 10.3760/cma.j.cn115354-20240612-00341.
[3]
文先永. 微创软通道穿刺引流术与开颅血肿清除术治疗高血压脑出血80例的疗效分析[J]. 世界复合医学, 2021, 7(7): 119-121, 125. DOI: 10.11966/j.issn.2095-994X.2021.07.07.36.Wen XY. Analysis of the curative effect of 80 cases of hypertensive cerebral hemorrhage treated by minimally invasive soft channel drainage and craniotomy for hematoma removal[J].World Journal of Complex Medicine, 2021, 7(7): 119-121, 125.DOI: 10.11966/j.issn.2095-994X.2021.07.07.36.
[4]
王彩红, 邱玉发, 姜明, 等. 神经内镜微创手术对脑出血患者治疗的临床分析[J]. 临床神经外科杂志, 2023, 20(6): 691-695.DOI: 10.3969/j.issn.1672-7770.2023.06.017.Wang CH, Qiu YF, Jiang M, et al. Clinical analysis on minimally invasive neuroendoscopic surgery for patients with cerebral hemorrhage[J]. J Chin Neurosurg, 2023, 20(6): 691-695. DOI: 10.3969/j.issn.1672-7770.2023.06.017.
[5]
中华医学会神经病学分会, 中华医学会神经病学分会脑血管病学组. 中国脑出血诊治指南(2019)[J]. 中华神经科杂志,2019, 52(12): 994-1005. DOI: 10.3760/cma.j.issn.1006-7876. 2019.12.003.Chinese Society of Neurology; Cerebrovascular Group, Chinese Society of Neurology. Chinese guidelines for diagnosis and treatment of acute intracerebral hemorrhage 2019[J]. Chin J Neurol, 2019,52(12): 994-1005. DOI: 10.3760/cma.j.issn.1006-7876.2019.12.003.
[6]
王秀杰, 郑富霞, 熊鑫, 等. 患者入院时血浆Lp-PLA2、LP(b)、NIHSS评分及MoCA评分对急性缺血性脑卒中预后不良的预测效能[J]. 山东医药, 2024, 64(9): 60-64. DOI: 10.3969/j.issn.1002-266X.2024.09.014.Wang XJ, Zheng FX, Xiong X, et al. Predictive efficacy of plasma LP-PLA2, LP(b), NIHSS score and MoCA score on admission to acute ischemic stroke[J]. Shandong Med J, 2024, 64(9): 60-64.DOI: 10.3969/j.issn.1002-266X.2024.09.014.
[7]
McMillan T, Wilson L, Ponsford J, et al. The Glasgow Outcome Scale-40 years of application and refinement[J]. Nat Rev Neurol,2016, 12(8): 477-485. DOI: 10.1038/nrneurol.2016.89.
[8]
戴倩, 熊小燕, 陆旭婷, 等. 用药数量和Barthel指数对住院老年人跌倒的影响[J]. 实用老年医学, 2024, 38(3): 312-316. DOI:10.3969/j.issn.1003-9198.2024.03.024.Dai Q, Xiong XY, Lu XT, et al. Effects of multiple drugs and Barthel index on falls in hospitalized elderly[J]. Pract Geriatr,2024, 38(3): 312-316. DOI: 10.3969/j.issn.1003-9198.2024.03.024.
[9]
张芳芳, 王雪钢, 王晶, 等. 围手术期配合方案对高血压性脑出血患者的干预效果观察[J]. 血管与腔内血管外科杂志, 2023, 9(2): 239-244. DOI: 10.19418/j.cnki.issn2096-0646.2023.02.24.Zhang FF, Wang XG, Wang J, et al. Observation on the intervention effect of perioperative cooperation plan on patients with hypertensive cerebral hemorrhage[J]. Journal of Vascular and Endovascular Surgery, 2023, 9(2): 239-244. DOI: 10.19418/j.cnki.issn2096-0646.2023.02.24.
[10]
石瑞娇, 吴红伟, 孙志民. 高血压性脑出血患者临床结局与神经内分泌因子的关系[J]. 标记免疫分析与临床, 2023, 30(12):1995-2000. DOI: 10.11748/bjmy.issn.1006-1703.2023.12.004.Shi RJ, Wu HW, Sun ZM. The relationship between clinical outcome and neuroendocrine factors in patients with hypertensive cerebral hemorrhage[J]. Lab Immun Clin Med, 2023, 30(12): 1995-2000. DOI: 10.11748/bjmy.issn.1006-1703.2023.12.004.
[11]
王越, 于世海, 张帅, 等. 幕上高血压性脑出血个体化治疗的疗效观察[J]. 中国临床神经外科杂志, 2023, 28(4): 269-270. DOI:10.13798/j.issn.1009-153X.2023.04.013.Wang Y, Yu SH, Zhang S, et al. Observation on the effect of individualized treatment for supratentorial hypertensive intracerebral hemorrhage[J]. Chin J Clin Neurosurg, 2023, 28(4): 269-270. DOI:10.13798/j.issn.1009-153X.2023.04.013.
[12]
赵帅杰, 李亚飞, 王昊天, 等. 神经内镜微创手术治疗高血压脑出血的临床效果及预后[J]. 河南医学研究, 2023, 32(14): 2550-2553. DOI: 10.3969/j.issn.1004-437X.2023.14.014.Zhao SJ, Li YF, Wang HT, et al. Effect of minimally invasive neuroendoscopic surgery and prognostis of patients with hypervascular cerebral hemorrhage[J]. Henan Med Res, 2023, 32(14): 2550-2553. DOI: 10.3969/j.issn.1004-437X.2023.14.014.
[13]
李文生, 黄瑞宏. 神经内镜微创手术与显微手术治疗高血压性小脑出血的临床效果比较[J]. 中国当代医药, 2021, 28(3): 106-108. DOI: 10.3969/j.issn.1674-4721.2021.03.031.Li WS, Huang RH. Clinical effect comparison of minimally invasive neuroendoscopic surgery and microsurgery in the treatment of hypertensive cerebellar hemorrhage[J]. Chin Mod Med, 2021,28(3): 106-108. DOI: 10.3969/j.issn.1674-4721.2021.03.031.
[14]
余文运, 祝圆圆, 唐宁, 等. 神经内镜在高血压脑出血破入脑室手术中的应用[J]. 中国现代手术学杂志, 2023, 27(3): 237-241.DOI: 10.16260/j.cnki.1009-2188.2023.03.012.Yu WY, Zhu YY, Tang N, et al. The application of neuroendoscopy in the surgery of hypertensive intracerebral hemorrhage breaking into the ventricles[J]. Chin J Mod Oper Surg,2023, 27(3): 237-241. DOI: 10.16260/j.cnki.1009-2188.2023.03.012.
[15]
孟艳举, 王路, 郝志勇, 等. 神经内镜微创手术在高血压脑出血中的应用[J]. 华夏医学, 2023, 36(4): 93-97. DOI: 10.19296/j.cnki.1008-2409.2023-04-017.Meng YJ, Wang L, Hao ZY, et al. Application of minimally invasive neuroendoscopic surgery in hypertensive intracerebral hemorrhage[J]. Acta Medicinae Sinica, 2023, 36(4): 93-97. DOI:10.19296/j.cnki.1008-2409.2023-04-017.
[16]
李元贵, 杨燕文, 王晓麒, 等. 软通道血肿穿刺引流术与神经内镜颅内血肿清除术治疗高血压脑出血的疗效[J]. 实用医学杂志, 2023, 39(7): 833-837. DOI: 10.3969/j.issn.1006-5725.2023.07.007.Li YG, Yang YW, Wang XQ, et al. Comparative analysis of soft channel puncture drainage and neural endoscopic intracranial hematoma evacuation in the treatment of hypertensive cerebral hemorrhage[J]. The Journal of Practical Medicine, 2023, 39(7):833-837. DOI: 10.3969/j.issn.1006-5725.2023.07.007.
[1] 熊伟, 杨华, 肖现, 黄仁强, 卢昆, 王松青. 炎症反应与创伤性脊髓损伤严重程度及神经功能改善的相关性[J/OL]. 中华神经创伤外科电子杂志, 2024, 10(06): 330-339.
[2] 李刚, 潘晓帆, 田雪, 刘路路. CT灌注成像参数及血栓弹力图对急性前循环脑梗死早期神经功能恶化的预测价值分析[J/OL]. 中华神经创伤外科电子杂志, 2024, 10(04): 226-232.
[3] 崔鑫, 张鹏, 古同男, 赵艳芝. 舒巴坦对局灶性脑缺血再灌注大鼠脑组织损伤的影响[J/OL]. 中华神经创伤外科电子杂志, 2023, 09(06): 333-337.
[4] 盛成俊, 沈宇晟, 李彦东, 贺诗茹, 吴徐超, 赵小玉, 曾加, 麦麦提力·米吉提, 更·党木仁加甫, 朱国华. Koos3、4级前庭神经鞘瘤在桥小脑角区的生长方向对面神经功能的影响[J/OL]. 中华神经创伤外科电子杂志, 2023, 09(04): 216-221.
[5] 景方坤, 周建波, 王全才, 黄海韬, 李岩峰, 徐杨熙. 神经导航引导下治疗基底节高血压脑出血的短期疗效预测[J/OL]. 中华脑科疾病与康复杂志(电子版), 2024, 14(03): 154-159.
[6] 董西朝, 王林林, 袁致海, 高文文. 超早期经脑沟裂入路与经脑回皮质入路显微手术治疗基底节区脑出血的疗效分析[J/OL]. 中华脑科疾病与康复杂志(电子版), 2024, 14(02): 100-105.
[7] 张友晶, 贾砚慧, 陈恕凤. 睡眠与心率变异性关系的研究进展[J/OL]. 中华心脏与心律电子杂志, 2023, 11(04): 242-246.
[8] 潘鑫, 黄晓云, 王超, 顾慧, 唐加波, 王鹏, 崔恒熙, 李政. 院前亚低温结合院内溶栓救治急性脑梗死的效果[J/OL]. 中华卫生应急电子杂志, 2024, 10(03): 145-148.
[9] 王辉, 胡玉姣, 李鹏飞. 老年高血压脑出血患者脑血肿扩大影响因素的预测价值[J/OL]. 中华脑血管病杂志(电子版), 2025, 19(01): 48-53.
[10] 吴仔弦, 杨思敏, 周保纯. 定量脑电图在成人重症监护室中的应用[J/OL]. 中华脑血管病杂志(电子版), 2024, 18(06): 616-620.
[11] 王育伟, 杨琼, 丁文华, 邱景景, 耿玉荣. 脑小血管病排尿障碍研究进展及机制探讨[J/OL]. 中华脑血管病杂志(电子版), 2024, 18(06): 606-610.
[12] 李小勇, 郭海志, 赵洋. QSM 联合SWI 预测急性缺血性脑卒中患者EVT 后神经功能的价值[J/OL]. 中华脑血管病杂志(电子版), 2024, 18(06): 549-555.
[13] 唐欣, 翟文海, 王润婷, 周胜宇, 靳航. 补体在缺血性卒中疾病中的研究进展[J/OL]. 中华脑血管病杂志(电子版), 2024, 18(04): 382-392.
[14] 王永彬, 贾彦迅, 尹轶广. 神经导航结合3D重建技术引导神经内镜血肿清除术对高血压脑出血患者的影响[J/OL]. 中华脑血管病杂志(电子版), 2024, 18(02): 153-156.
[15] 朱敏, 李法强. 血清GFAP、UCH-L1联合VILIP-1水平对急性脑梗死神经功能预后不良的预测研究[J/OL]. 中华脑血管病杂志(电子版), 2023, 17(05): 452-457.
阅读次数
全文


摘要