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中华脑科疾病与康复杂志(电子版) ›› 2025, Vol. 15 ›› Issue (03) : 148 -152. doi: 10.3877/cma.j.issn.2095-123X.2025.03.003

功能神经外科

短时程周围神经电刺激治疗带状疱疹后神经痛的效果分析
孙兵1, 杜秀玉2,(), 郭小川2, 周小宝2, 卢海涛2, 智德豹2   
  1. 1201108 上海,复旦大学华山医院神经外科
    2200071 上海,上海中医药大学附属市中医医院神经外科
  • 收稿日期:2025-03-03 出版日期:2025-06-15
  • 通信作者: 杜秀玉

Effect analysis of short-course peripheral nerve stimulation on postherpetic neuralgia

Bing Sun1, Xiuyu Du2,(), Xiaochuan Guo2, Xiaobao Zhou2, Haitao Lu2, Debao Zhi2   

  1. 1Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 201108, China
    2Department of Neurosurgery, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, China
  • Received:2025-03-03 Published:2025-06-15
  • Corresponding author: Xiuyu Du
  • Supported by:
    National Key R& D Program of China(2022YFC240500)
引用本文:

孙兵, 杜秀玉, 郭小川, 周小宝, 卢海涛, 智德豹. 短时程周围神经电刺激治疗带状疱疹后神经痛的效果分析[J/OL]. 中华脑科疾病与康复杂志(电子版), 2025, 15(03): 148-152.

Bing Sun, Xiuyu Du, Xiaochuan Guo, Xiaobao Zhou, Haitao Lu, Debao Zhi. Effect analysis of short-course peripheral nerve stimulation on postherpetic neuralgia[J/OL]. Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition), 2025, 15(03): 148-152.

目的

探讨短时程周围神经电刺激(st-PNS)治疗带状疱疹后神经痛(PHN)的有效性与安全性。

方法

回顾性分析上海中医药大学附属市中医医院神经外科自2023年10月至2024年10月接受st-PNS治疗的15例PHN患者的临床资料。采用数字评分表(NRS)评估患者的疼痛程度,采用抑郁自评量表(SDS)和焦虑自评量表(SAS)评估患者的心理状态。收集并分析患者的性别、年龄、疼痛病程、术前SAS评分、术前SDS评分、电刺激时间、围术期NRS评分及术后NRS改善率等资料,分析st-PNS的临床治疗效果,记录不良反应的发生情况。

结果

本组患者的刺激时间范围为7~16 d,中位数(四分位数)为14(13,15) d;术前NRS评分范围为7~10分,中位数(四分位数)为8(7,9)分,术后NRS评分平均2.27分。所有患者的疼痛程度较术前均有改善,有效率100%,NRS平均下降(5.87±1.25)分;手术后NRS平均改善率73.20%±18.15%。本组患者术前SDS平均37.27分,术前SAS 20~75分,中位数(四分位数)为32(23,58)分。术前NRS、SDS、SAS评分与NRS改善率呈负相关(r=-0.517,P=0.048;r=-0.928,P<0.001;r=-0.895,P<0.001)。本组患者中无感染及其他不良反应发生。

结论

st-PNS可以安全有效地改善PHN,但治疗效果受到术前NRS、SDS、SAS评分等因素的影响。

Objective

To investigate the technical methods, effectiveness and safety of short-course peripheral nerve stimulation (st-PNS) in the treatment of postherpetic neuralgia (PHN).

Methods

The clinical data of fifteen patients with PHN treated with st-PNS from October 2023 to October 2024 were collected retrospectively. Numeric rating scale (NRS) was used for pain scoring, self-rating depression scale (SDS) and self-rating anxiety scale (SAS) was used for evaluation of psychological status. The data of gender, age, the duration of pain, preoperative SAS, preoperative SDS, the time of st-PNS, perioperative NRS and the improvement rate of NRS were collected and analyzed, to evaluate the effectiveness and side effects of st-PNS, and the related Factors-of the rate of NRS improvement.

Results

The stimulation time of this group of patients ranged from 7 to 16 d, with a median (quartile) of 14 (13, 15) d; The preoperative NRS score ranged from 7 to 10 points, with a median (quartile) of 8 (7, 9) points, mean postoperative NRS was 2.27 points. The pain degree of all patients was improved compared with that before operation, the effective rate was 100%, and the mean decline of NRS was (5.87±1.25) points, the mean improvement rate of NRS after surgery was 73.20%±18.15%. The average preoperative SDS score was 37.27, the preoperative SAS score was 20-75, and the median (quartile) score was 32 (23, 58). There was a significant correlation between preoperative NRS, preoperative SDS, and preoperative SAS and improvement rate of NRS (r=-0.517, P=0.048; r=-0.928, P<0.001; r=-0.895, P<0.001). There was no infection or other adverse reactions had happened.

Conclusions

st-PNS is safe and effective in improving PHN, but the effectiveness is affected by factors such as preoperative NRS, preoperative SDS, and preoperative SAS.

图1 疱疹后疼痛区域与电极放置位置示意图红色箭头所指的红线内区域为疼痛区域;白色箭头所指的白色方框区域为刺激电极所放置位置;黄色星号标识为疼痛程度标识,其密集程度代表疼痛程度;绿色箭头代表刺激电极放电方向
Fig.1 Schematic diagram of the area of PHN and the location of electrode
图2 不同影响因素与术后疼痛NRS评分改善率的相关性分析(n=15)A:年龄;B:PHN病程;C:st-PNS刺激时间;D:术前NRS评分;E:术前SDS评分;F:术前SAS评分
Fig.2 Correlation analysis between different influencing factors and improvement rate of postoperative NRS (n=15)
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