Research on the relationship between dopamine and epilepsy

doi:10.3877/cma.j.issn.2095-123X.2017.02.008

Abstract

Abstract:

As one of monoamine neurotransmitters in the central nervous system, dopamine participates in the regulation of many kinds of neural activities.Epilepsy is a common disease, frequently occurring disease and the pathogenesis is unknown, which is one of the difficult points in the domestic and foreign research. Studies have found that dopamine is closely related to the occurrence of epilepsy, which is a hot research topic at home and abroad.The structure, distribution, biological function and regulation mechanism of dopamine and its relationship with epilepsy were reviewed in this paper, which provide a new theoretical basis for the targeted therapy of epilepsy and improve the level of prevention and treatment of epilepsy is of great value.

Key words: Epilepsy, Dopamine, Dopamine receptor

Min Gao, Jingjun Zhang. Research on the relationship between dopamine and epilepsy[J]. Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition), 2017, 07(02): 83-86.

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References 29

[1]	Baik JH.Dopamine signaling in reward-related behaviors[J]．Front Neural Circuits，2013，7(11)：152.
[2]	Martorana A, Koch G. Is dopamine involved in Alzheimer′s disease[J]．Front Aging Neurosci，2014，6(25): 252.
[3]	Aoki Y, Nishizawa D, Kasai S，et al. Association between the variable number of tandem repeat polymorphism in the third exon of the dopamine D4 receptor gene and sensitivity to analgesics and pain in patients undergoing painful cosmetic surgery[J]. Neuroscience letters，2013，542(10)：1-4.
[4]	Trossbach SV, de Souza Silva MA, Huston JP，et al.Intranasal dopamine treatment reinstates object-place memory in aged rats[J]．Neurobiol Learn Mem，2014，114(1)：231-235.
[5]	Seyedabadi M, Fakhfouri G, Ramezani V，et al.The role of serotonin in memory：interactions with neurotransmitters and downstream signaling[J]. Exp Brain Res，2014，232(3): 723-738.
[6]	Mendoza J, Challet E．Circadian insights into dopamine mechanisms[J]. Neuroscience，2014，282(12): 230-242.
[7]	Koch G, Di Lorenzo F, Bonni S，et al.Dopaminergic modulation of cortical plasticity in Alzheimer′s disease patients[J]．NeuropsychopharMCAOlogy, 2014，39(11): 2654-2661.
[8]	Chandler DJ, Waterhouse BD, Gao WJ.New perspectives on catecholaminergic regulation of executive circuits: evidence for independent modulation of prefrontal functions by midbrain dopaminergic and noradrenergic neurons[J]. Front Neural Circuits, 2014，8(21)：53.
[9]	Cachope R, Cheer JF.Local control of striatal dopamine release[J]．Front Behav Neurosci，2014，8(23)：188.
[10]	Jonas RK, Montojo CA, Bearden CE.The 22q11. 2 deletion syndrome as a window into complex neuropsychiatric disorders over the lifespan[J]. Biol Psychiatry, 2014，75(5) ：351-360.
[11]	Nakajima S, Gerretsen P, Takeuchi H, et al. The potential role of dopamine D(3) receptor neurotransmission in cognition[J]. Eur Neuropsychopharmcaol, 2013，23(8): 799-813.
[12]	Prado C, Bernales S, Pacheco R．Modulation of T-cell mediated immunity by dopamine receptor d5[J]. Endocr Metab Immune Disord Drug Targets，2013，13(2)：184-194.
[13]	Surmeier DJ, Carrillo-Reid L, Bargas J. Dopaminergic modulation of striatal neurons, circuits，and assemblies[J]. Neuroscience, 2011, 198(15)：3-18.
[14]	Rektor I, Kuba R, Brázdil M，et al. Do the basal ganglia inhibit seizure activity in temporal lobe epilepsy[J]．Epilepsy Behav，2012, 25 (1)：56-59.
[15]	Rocha L, Alonso-Vanegas M, Villeda-Hernández J，et al.Dopamine abnormalities in the neocortex of patients with temporal lobe epilepsy[J]. Neurobiol Dis，2012，45(1)：499-507.
[16]	Bozzi Y, Borrelli E. The role of dopamine signaling in epileptogenesis[J]．Front Cell Neurosci, 2013，7(17)：157.
[17]	Kovacs A, Mihaly A, Komaromi A，et al.Seizure，Neuro transmitter Release , and Gene Expression are Closely Related in the Striatum of 4-aminopyridine treated Rats[J]．Epilepsy Res，2003，55(1-2)：117-129.
[18]	Cifellip, Grace AA.Pilocarpine Induced Temporal Lobe Epilepsy in the Rat is Associated with Increased Dopamine Neuron Activity[J]．Int J Neuropsychopharmacol, 2012，15(7)：957-964.
[19]	Shouse MN, Staba RJ, Ko PY, et al .Monoamines and seizures：microdialysis findings in locs ceruleus and amygdala before and during amygdala kindling[J]．Brain Res，2001，892(1) ：176-192.
[20]	Bozzi Y, Borrelli E. Dopamine in neurotoxicity and neuroprotection: what do D2 receptors have to do with it[J]．Trends Neurosci, 2006，29(3)：167-174.
[21]	Al-Tajir G, Starr MS. D-2 agonists protect rodents against pilocarpine-induced convulsions by stimulating D-2 receptors in the striatum, but not in the substantia nigra[J]．Pharmacol Biochem Behav, 1991, 39(1)：109-113.
[22]	Rocha L, Alonso-Vanegas M, Villeda-Hernández J，et al.Dopamine abnormalities in the neocortex of patients with temporal lobe epilepsy[J]．Neurobiol Dis, 2012，45(1)：499-507.
[23]	Bernedo Paredes VE, Buchholz HG, Gartenschläger M，et al.Reduced D2/D3 Receptor Binding of Extrastriatal and Striatal Regions in Temporal Lobe Epilepsy[J]．PLoS One, 2015，10(11)：e0141098.
[24]	Yakushev IY, Dupont E, Buchholz HG，et al.In vivo imaging of dopamine receptors in a model of temporal lobe epilepsy[J]．Epilepsia, 2010，51(3)：415-422.
[25]	Dahlin M, Mansson JE, Amark P．CSF levels of dopamine and serotonin, but not norepinephrine, metabolites are influenced by the ketogenic diet in children with epilepsy[J]．Epilepsy Res, 2012，99(1-2)：132-138.
[26]	Fedi M, Berkovic SF, Scheffer IE, et al. Reduced striatal D1 receptor binding in autosomal dominant nocturnal frontal lobe epilepsy[J]．Neurology, 2008，71(11)：795-798.
[27]	Landvogt C, Buchholz HG, Bernedo V，et al.Alteration of dopamine D2/D3 receptor binding in patients with juvenile myoclonic epilepsy[J]. Epilepsia, 2010，51(9)：1699-1706.
[28]	Odano I, Varrone A, Savic I, et al. Quantitative PET analyses of regional [11C]PE2I binding to the dopamine ransporter-application to juvenile myoclonic epilepsy[J]．Neuroimage, 2012，59(4)：3582-3593.
[29]	Ciumas C, Wahlin TB, Espino C, et al. The dopamine system in idiopathic generalized epilepsies: identification of syndrome-related changes[J]．Neuroimage, 2010，51(2)：606-615.

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