Abstract:

Parkinson's disease （PD） is a progressive neurodegenerative disorder with both motor and non-motor symptoms. Deep brain stimulation （DBS） is applicable to advanced PD patients whose symptoms cannot be adequately controlled by medication and whose quality of life cannot be well guaranteed，as well as to those who have severe adverse reactions（such as dyskinesia）due to dopaminergic drugs. DBS can provide personalized treatment according to the specific symptoms of patients，and the treatment is carried out for different nodes in the basal ganglia-thalamus pathway，and these nodes play a mediating role in various symptoms of the disease. DBS of the ventral intermediate nucleus of the thalamus is the most effective in controlling tremors，DBS of the globus pallidus is significantly effective in controlling rigidity and dyskinesia，while DBS of the subthalamic nucleus can simultaneously treat tremors，bradykinesia，rigidity and dyskinesia，and can reduce the amount of medication used by patients，and is also the preferred treatment goal in the late stage of the disease. DBS has a long-term therapeutic effect on limb symptoms，but as the disease progresses，the response of non-dopaminergic axial features to DBS will gradually deteriorate.The DBS treatment of PD is highly specialized and requires a multidisciplinary team composed of movement disorder neurologists，functional neurosurgeons，professional DBS programmers，and neuropsychologists to screen and follow up patients. This article reviews the pathological mechanism，the applicability，efficacy，adverse reactions，and brain targets of DBS，in order to provide a more comprehensive understanding of the application of DBS in the treatment of PD and promote the further development in this field.

Key words: Parkinson's disease, Deep brain stimulation, Subthalamic nucleus, Functional neurosurgery