Clinical study of treatments to cognitive impairment by repetitive transcranial magnetic stimulation combined with donepezil on patients with stroke

doi:10.3877/cma.j.issn.2095-123X.2019.05.007

Abstract

Abstract:

Objective

To investigate the clinical efficacy of repetitive transcranial magnetic stimulation (rTMS) combined with donepezil in the treatment of post-stroke cognitive impairment (PSCI) patients.

Methods

Seventy-six PSCI patients, admitted to Department of Neurology Rehabilitation of Suzhou Ruisheng Rehabilitation Hospital from January 2018 to September 2019, were randomly divided into control group (n=38) and experimental group (n=38). Both groups were given routine rehabilitation treatment. In the experimental group, oral donepezil combined with 10 Hz rTMS was added. Before and 4 weeks after treatment, the cognitive function and the ability of daily living of the patients were evaluated by the Montreal cognitive assessment scale (MoCA), concise mental state check table (MMSE), modified Barthel index (MBI).

Results

The MoCA score, MMSE score and MBI score of the two groups after 4 weeks of treatment were higher than those before treatment, and the MoCA score, MMSE score and MBI score of the experimental group after 4 weeks of treatment were higher than those of the control group, the differences were statistically significant (P<0.05).

Conclusion

Donepezil combined with rTMS can improve the cognitive dysfunction and daily living ability of PSCI patients on a short period of time.

Key words: Repetitive transcranial magnetic stimulation, Donepezil, Stroke, Cognitive impairment

Xuemei Zhou, Zhanyu Yang, Yan Wu, Xiang Zhang, Shan Qiao, Yanping Guo. Clinical study of treatments to cognitive impairment by repetitive transcranial magnetic stimulation combined with donepezil on patients with stroke[J]. Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition), 2019, 09(05): 285-288.

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References 25

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组别	例数	年龄（岁）	性别		病程（d）	文化程度
组别	例数	年龄（岁）	男	女	病程（d）	文盲	小学	中学
对照组	38	59.68±8.00	26	12	29.29±8.23	8	15	15
观察组	38	59.76±8.52	24	14	27.18±6.67	11	14	13
t/χ²值	?	-0.042	0.234		1.225	0.651
P值	?	0.967	0.629		0.224	0.722

组别	例数	年龄（岁）	性别		病程（d）	文化程度
组别	例数	年龄（岁）	男	女	病程（d）	文盲	小学	中学
对照组	38	59.68±8.00	26	12	29.29±8.23	8	15	15
观察组	38	59.76±8.52	24	14	27.18±6.67	11	14	13
t/χ²值	?	-0.042	0.234		1.225	0.651
P值	?	0.967	0.629		0.224	0.722

评分	组别	例数	治疗前	治疗后	t值	P值
MoCA	对照组	38	10.95±5.01	15.32±5.75	-7.966	0.000
	观察组	38	11.16±5.01	19.08±5.82	-14.874	0.000
	t值	?	-0.183	-2.835	?	?
	P值	?	0.855	0.006	?	?
MMSE	对照组	38	12.50±5.31	17.39±4.67	-7.946	0.000
	观察组	38	13.03±5.51	21.11±4.31	-11.13	0.000
	t值	?	-0.424	-3.599	?	?
	P值	?	0.673	0.001	?	?
MBI	对照组	38	25.45±17.26	56.79±21.94	-15.362	0.000
	观察组	38	25.50±17.57	66.82±17.67	-25.298	0.000
	t值	?	-0.013	-2.194	?	?
	P值	?	0.990	0.031	?	?

评分	组别	例数	治疗前	治疗后	t值	P值
MoCA	对照组	38	10.95±5.01	15.32±5.75	-7.966	0.000
	观察组	38	11.16±5.01	19.08±5.82	-14.874	0.000
	t值	?	-0.183	-2.835	?	?
	P值	?	0.855	0.006	?	?
MMSE	对照组	38	12.50±5.31	17.39±4.67	-7.946	0.000
	观察组	38	13.03±5.51	21.11±4.31	-11.13	0.000
	t值	?	-0.424	-3.599	?	?
	P值	?	0.673	0.001	?	?
MBI	对照组	38	25.45±17.26	56.79±21.94	-15.362	0.000
	观察组	38	25.50±17.57	66.82±17.67	-25.298	0.000
	t值	?	-0.013	-2.194	?	?
	P值	?	0.990	0.031	?	?

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