比较不同时间发作的癫痫患者睡眠结构的特征。

选取2016年3月至2016年12月就诊于山西医科大学第一医院神经内科门诊的癫痫患者88例及年龄、性别与癫痫患者匹配的健康人群80例为研究对象。根据癫痫发作在一天中时间段的不同将癫痫患者分为3组：夜间发作组(仅夜间发作的癫痫患者30例)、白天发作组(仅白天发作的癫痫患者30例)、以及混合发作组(白天和夜间都有发作的癫痫患者28例)，以健康人群(80例)为对照组。各组均于我院神经内科脑电图室(EEG)行多导睡眠监测(PSG)。通过多导睡眠图分析其睡眠参数，比较癫痫组和健康对照组的睡眠结构的不同，进一步比较三组癫痫患者的睡眠结构不同。

1．癫痫组与健康对照组比较，总睡眠时间明显缩短(P<0.05)，睡眠效率显著下降(P<0.05)，睡眠潜伏期、快速眼动睡眠(REM)潜伏期均延长(P均<0.05)，非快速眼动睡眠(NREM)1期、2期及清醒期占总睡眠时间的百分比明显增加(P均<0.05)，NREM3＋4期、REM期占总睡眠时间的百分比明显减少(P<0.05)。2.夜间发作组与白天发作组比较：总睡眠时间明显减少(P<0.05)，睡眠潜伏期与REM潜伏期延长(P<0.05)，睡眠效率明显下降(P<0.05)，NREM1期、2期及清醒期占总睡眠时间的百分比明显增加(P均<0.05)，NREM3＋4期、REM期占总睡眠时间的百分比明显减少(P<0.05)。3.夜间发作组与混合发作组相比：睡眠潜伏期与REM潜伏期明显延长(P<0.05)，NREM1期、2期及清醒期占总睡眠时间的百分比显著增加(P<0.05)，而总睡眠时间明显减少(P<0.05)、睡眠效率显著(P<0.05)下降，NREM的3＋4期与REM期占总睡眠时间的百分比减少(P<0.05)。4.混合发作组与白天发作组比较：总睡眠时间明显减少(P<0.05)，睡眠效率显著下降(P<0.05)，NREM1期、2期与清醒期占总睡眠时间的百分比增加(P<0.05)，NREM3＋4期与REM期占总睡眠时间的百分比减少(P<0.05)，而睡眠潜伏期与REM潜伏期明显延长(P<0.05)。

1．癫痫组与健康对照组相比，睡眠结构有明显的差异；2.夜间发作组、白天发作组、混合发作组三组相互比较，睡眠结构均有显著性差异，其中夜间发作组的睡眠结构变化更大。

To compare the characteristics of sleep structure in patients with epilepsy at different times.

From March 2016 to December 2016, 88 patients with epilepsy in the Department of Neurology, the First Hospital of Shanxi Medical University were enrolled in this study, eighty patients with age and gender matched with epilepsy were selected as the subjects. According to the different seizures of epilepsy, epilepsy patients were divided into three groups: the night attack group (30 cases of epilepsy only at night), daytime attack group (30 cases of epilepsy only during daytime), and mixed attack group (28 cases of epilepsy patients who had seizures during the day and night), and healthy people (80 cases) as the control group. All groups were given polysomnography (PSG) in neurological electroencephalograph (EEG) room. The sleep parameters were analyzed by polysomnography, and the sleep structure of the epilepsy group and the healthy control group were compared. The sleep structure of the three groups of epilepsy patients was further compared.

1. Comparison of epilepsy group and healthy control group: the total sleep time was significantly shortened (P<0.05), sleep efficiency was significantly decreased (P<0.05), sleep latency, rapid eye movement sleep (REM) latency were extended (P<0.05). The percentage of total sleep time was significantly increased in non-rapid eye movement sleep (NREM) stage 1 and 2 and awake period (all P<0.05), NREM3 + 4 period, REM period accounted for the total sleep time percentage was significantly reduced (P<0.05). 2.Night attack group compared with daytime attack group: total sleep time was significantly reduced(P<0.05), sleep latency and REM latency prolonged, sleep efficiency decreased significantly, NREM1 and 2 stage and awake period significantly increased the percentage of total sleep time, NREM3 + 4 period, REM period accounted for the total sleep time percentage was significantly reduced (P<0.05). 3.Night attack group compared with mixed attack group: sleep latency and REM latency were significantly prolonged (P<0.05), NREM1 and 2 stage and awake accounted for a significant increase in the percentage of total sleep time (P<0.05), while the total sleep time was significantly reduced, sleep efficiency decreased significantly, NREM 3+ 4 period and REM period decreased the total sleep time percentage.4.Comparison of the mixed attack group and the daytime attack group: the total sleep time was significantly reduced(P<0.05), sleep efficiency decreased significantly(P<0.05), NREM1 and 2 stage and awake period increased the percentage of total sleep time(P<0.05), NREM3 + 4 and REM decreased the percentage of total sleep time(P<0.05), while the sleep latency and REM latency were significantly prolonged(P<0.05).

1.There is a significant difference in the sleep structure between the epilepsy group and the healthy control group.2.There are significant differences in sleep structure among the three groups of night group, daytime attack group and mixed attack group, and the sleep structure of night attack group changes more.