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中华脑科疾病与康复杂志(电子版)

中华脑科疾病与康复杂志(电子版) ›› 2023, Vol. 13 ›› Issue (05) : 304 -308. doi: 10.3877/cma.j.issn.2095-123X.2023.05.008

临床研究

癫痫患者定量脑电图功率谱相关参数与认知功能损伤的相关性研究
吴新高†(), 李伟, 马俊, 刘红, 黄平   
  1. 434300　湖北荆州，公安县人民医院神经内科
  • 收稿日期:2022-08-17 出版日期:2023-10-15
  • 通信作者: 吴新高

Correlation between quantitative electroencephalogram power spectrum related parameters and cognitive impairment in patients with epilepsy

Xingao Wu†(), Wei Li, Jun Ma, Hong Liu, Ping Huang   

  1. Department of Neurology, Gongan County People's Hospital, Jingzhou 434300, China
  • Received:2022-08-17 Published:2023-10-15
  • Corresponding author: Xingao Wu
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吴新高, 李伟, 马俊, 刘红, 黄平. 癫痫患者定量脑电图功率谱相关参数与认知功能损伤的相关性研究[J]. 中华脑科疾病与康复杂志(电子版), 2023, 13(05): 304-308.

Xingao Wu, Wei Li, Jun Ma, Hong Liu, Ping Huang. Correlation between quantitative electroencephalogram power spectrum related parameters and cognitive impairment in patients with epilepsy[J]. Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition), 2023, 13(05): 304-308.

目的

分析癫痫（EP）患者定量脑电图（QEEG）功率谱相关参数与认知功能损伤的相关性。

方法

选取公安县人民医院神经内科自2019年8月至2021年8月收治的130例EP患者纳入观察组，另按1∶1比例选取同期在本院接受体检的130例健康志愿者纳入对照组，比较2组受试者的临床记忆量表（CMS）评分。根据记忆商(MQ)分值将EP患者分为认知功能损伤组（MQ<90分）和认知功能正常组（MQ≥90分）。比较3组受试者的α、θ、β及δ频段百分比功率值，分析QEEG各频段百分比功率值与CMS评分的相关性。

结果

观察组CMS各维度分值均显著低于对照组，差异具有统计学意义（P<0.05）。EP患者中有54例MQ<90分，纳入认知功能损伤组，余76例MQ≥90分，纳入认知功能正常组。认知功能损伤组α频段百分比功率值显著低于认知功能正常组、对照组，θ频段、δ频段百分比功率值显著高于认知功能正常组、对照组，差异具有统计学意义（P<0.05）。Pearson相关性分析显示，QEEG α频段百分比功率值与MQ呈显著正相关（r=0.338，P<0.05），θ频段、δ频段百分比功率值与MQ呈显著负相关（r=-0.695、-0.724，P<0.05）。

结论

EP患者QEEG功率谱指标与认知功能损伤存在显著相关性，或可为EP患者认知功能干预提供参考意见。

关键词: 癫痫, 脑电图功率谱, 认知功能
Objective

To analyze the correlation between quantitative electroencephalography (QEEG) power spectrum related parameters and cognitive impairment in patients with epilepsy (EP).

Methods

A total of 130 patients with EP who were admitted to the Neurology Department at Gongan County People's Hospital from August 2019 to August 2021 were selected as the observation group. Meanwhile, 130 healthy volunteers who received health check-ups in the same hospital were selected as the control group. The clinical memory scale (CMS) scores were compared between the two groups. EP patients were divided into a cognitive impairment group [memory quotient (MQ)<90 points] and a cognitive normal group (MQ≥90 points) based on their MQ score. The percentage power values in α, θ, β and δ frequency bands of 3 groups were compared. The correlation between the percentage power value of each QEEG frequency band and CMS was analyzed.

Results

The scores for different dimensions of CMS in the observation group were significantly lower than those in the control group (P<0.05). Among EP patients, 54 patients had MQ score under 90 and they were included in the cognitive impairment group, the other 76 patients with MQ score of 90 or higher were included in the normal cognitive function group. The percentage power value of α frequency band in the cognitive impairment group was significantly lower than those in the normal cognitive function group and the control group. The percentage power values of θ and δ frequency bands were significantly higher than those in the normal cognitive function group and the control group (P<0.05). Pearson correlation analysis found that the percentage power value of QEEG α frequency band was positively correlated with MQ score (r=0.338, P<0.05). The percentage power values of θ and δ frequency bands were negatively correlated with MQ score (r=-0.695, -0.724, P<0.05).

Conclusion

There is a significant correlation between QEEG power spectrum parameters and cognitive impairment in patients with EP. These parameters may provide reference for cognitive function intervention of patients with EP.

Key words: Epilepsy, Electroencephalogram power spectrum, Cognitive function
表1 2组受试者的一般资料比较
Tab.1 Comparison of general information between two groups
组别 例数 性别[例（%）] 年龄（岁，Mean±SD） 受教育年限[年，M（P25，P75）]
男 女
观察组 130 71（54.62） 59（45.38） 24.17±5.09 13.50（12.00，19.00）
对照组 130 75（57.69） 55（42.31） 25.01±4.98 13.00（12.00，18.00）
χ2/t/Z值   0.250 1.345 0.620
P值   0.617 0.180 0.836
表2 观察组和对照组的CMS评分比较（分，Mean±SD）
Tab.2 Comparison of CMS scores between the observation group and the control group (score, Mean±SD)
CMS评分 观察组（n=130） 对照组（n=130） t值 P值
MQ 94.04±19.21 105.75±9.45 -6.219 <0.001
指向记忆 16.41±6.93 20.15±6.21 -4.578 <0.001
联想学习 23.29±9.06 26.88±5.51 -3.857 <0.001
图像自由回忆 17.84±6.92 25.76±3.78 -11.438 <0.001
无意义图形再认 17.81±4.47 20.64±2.93 -6.045 <0.001
人像特点联系回忆 18.90±6.67 22.30±5.79 -4.384 <0.001
表3 对照组和不同认知功能损伤程度癫痫患者各频段百分比功率值比较（Mean±SD）
Tab.3 Comparison of percentage power values in different frequency bands among the control group and epilepsy patients with different degrees of cognitive impairment (Mean±SD)
频段 对照组（n=130） 认知功能正常组（n=76） 认知功能损伤组（n=54） F值 P值
α 60.48±11.01 61.35±11.07 50.97±10.97ab 6.334 0.002
θ 4.01±1.97 4.02±1.07 7.54±1.55ab 44.915 <0.001
β 17.52±3.84 17.60±4.03 15.91±3.79 0.659 0.518
δ 2.93±0.40 2.91±0.46 5.94±1.54ab 66.333 <0.001
图1 癫痫患者MQ评分与QEEG α、θ、δ频段百分比功率值散点图
Fig.1 Scatter plot of MQ score and percentage power values of QEEG α, θ and δ frequency bands in epilepsy patients
[1]
Pack AM. Epilepsy overview and revised classification of seizures and epilepsies[J]. Continuum (Minneap Minn), 2019, 25(2): 306-321. DOI: 10.1212/CON.0000000000000707.
[2]
Rugg-Gunn F, Miserocchi A, McEvoy A. Epilepsy surgery[J]. Pract Neurol, 2020, 20(1): 4-14. DOI: 10.1136/practneurol-2019-002192.
[3]
Feter N, Alt R, Häfele CA, et al. Effect of combined physical training on cognitive function in people with epilepsy: results from a randomized controlled trial[J]. Epilepsia, 2020, 61(8): 1649-1658. DOI: 10.1111/epi.16588.
[4]
Huang Q, Liu J, Shi Z, et al. Correlation of MMP-9 and HMGB1 expression with the cognitive function in patients with epilepsy and factors affecting the prognosis[J]. Cell Mol Biol (Noisy-le-grand), 2020, 66(3): 39-47.
[5]
张慧敏,温晓红,黄金华,等.韦氏儿童智力量表第四版在癫痫儿童认知评估中的应用[J].中国儿童保健杂志, 2018, 26(10): 1120-1123. DOI: 10.11852/zgetbjzz2018-26-10-20.
[6]
Goenka A, Boro A, Yozawitz E. Assessing quantitative EEG spectrograms to identify non-epileptic events[J]. Epileptic Disord, 2017, 19(3): 299-306. DOI: 10.1684/epd.2017.0921.
[7]
Müller M, Schindler K, Goodfellow M, et al. Evaluating resective surgery targets in epilepsy patients: a comparison of quantitative EEG methods[J]. J Neurosci Methods, 2018: 15(305): 54-56. DOI: 10.1016/j.jneumeth.2018.04.021.
[8]
中华医学会.临床诊疗指南:癫痫病分册[M].北京:人民卫生出版社, 2007: 34-38.
[9]
"临床记忆量表"编制协作组. "临床记忆量表"的编制[J].心理学报, 1986, 18(1): 100-108.
[10]
Allone C, Lo Buono V, Corallo F, et al. Neuroimaging and cognitive functions in temporal lobe epilepsy: a review of the literature[J]. J Neurol Sci, 2017, 15(10), 381: 7-15. DOI: 10.1016/j.jns.2017.08.007.
[11]
Lee SY, Park JH, Park SJ, et al. Cognitive function and neuropsychological comorbidities in children with newly diagnosed idiopathic epilepsy[J]. J Korean Med Sci, 2018, 33(3): e17. DOI: 10.3346/jkms.2018.33.e17.
[12]
陈悦,杨增泰,张丽霞,等.间期癫痫样放电对癫痫患儿认知功能影响[J].中国实验诊断学, 2021, 25(5): 673-676. DOI: 10.3969/j.issn.1007-4287.2021.05.011.
[13]
何甲林子,肖波,刘超荣,等.颞叶癫痫认知功能障碍的特点及其临床影响因素[J].中南大学学报(医学版), 2021, 46(3): 240-248. DOI: 10.11817/j.issn.1672-7347.2021.200770.
[14]
Cohen E, Wong FY, Wallace EM, et al. EEG power spectrum maturation in preterm fetal growth restricted infants[J]. Brain Res, 2017, 1678: 180-186. DOI: 10.1016/j.brainres.2017.10.010.
[15]
廖红霞,杨加亮,杨渌.脑电图监测对额叶癫痫发作性患者的早期诊断及术中辅助定位价值研究[J].影像科学与光化学, 2021, 39(1): 19-23. DOI: 10.7517/issn.1674-0475.200707.
[16]
王若凡,刘静,王江,等.基于功率谱及有限穿越可视图的癫痫脑电信号分析算法[J].计算机应用, 2017, 37(1): 175-182. DOI: 10.11772/j.issn.1001-9081.2017.01.0175.
[17]
任晓卉,刑燕,李静.首治癫痫患儿脑电图与血清α-突触核蛋白和tau蛋白表达的相关性[J].中国妇幼保健, 2021, 36(15): 3586-3589. DOI: 10.19829/j.zgfybj.issn.1001-4411.2021.15.054.
[18]
马芸,徐海清,钱展,等. MMSE正常的帕金森病患者定量脑电图与早期认知障碍的相关性[J].中国神经免疫学和神经病学杂志, 2018, 25(1): 57-61. DOI: 10.3969/j.issn.1006-2963.2018.01.014.
[19]
吴越,汤莉,范洁,等.主观认知功能障碍老年人神经心理学及脑电图特征[J].中国老年学杂志, 2019, 39(7): 1634-1637. DOI: 10.3969/j.issn.1005-9202.2019.07.035.
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