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中华脑科疾病与康复杂志(电子版)

中华脑科疾病与康复杂志(电子版) ›› 2025, Vol. 15 ›› Issue (05) : 303 -308. doi: 10.3877/cma.j.issn.2095-123X.2025.05.009

综述

Treg细胞在神经病理性疼痛中的研究进展
崔滨1, 王丹慧2, 王林1,†(), 陈国强1   
  1. 1100012　北京，航空总医院神经外科
    2461000　河南许昌，许昌市中心医院神经内科
  • 收稿日期:2024-12-12 出版日期:2025-10-15
  • 通信作者: 王林

Research progress of Treg cells in neuropathic pain

Bin Cui1, Danhui Wang2, Lin Wang1,†(), Guoqiang Chen1   

  1. 1Department of Neurosurgery, Aviation General Hospital, Beijing 100012, China
    2Department of Neurology, Xuchang Central Hospital, Xuchang 461000, China
  • Received:2024-12-12 Published:2025-10-15
  • Corresponding author: Lin Wang
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引用本文：

崔滨, 王丹慧, 王林, 陈国强. Treg细胞在神经病理性疼痛中的研究进展[J/OL]. 中华脑科疾病与康复杂志(电子版), 2025, 15(05): 303-308.

Bin Cui, Danhui Wang, Lin Wang, Guoqiang Chen. Research progress of Treg cells in neuropathic pain[J/OL]. Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition), 2025, 15(05): 303-308.

神经病理性疼痛（NP）已成为影响人类健康的重大公共卫生问题，其病理机制尚未完全阐明，且现有药物治疗效果尚不理想，急需探寻新的治疗靶点与干预策略。特定免疫细胞亚群及其分泌的介质能够抑制伤害性信号传导，从而促进NP的缓解。调节性T（Treg）细胞作为关键的CD4+T淋巴细胞亚群，通过分泌抑制性细胞因子和细胞接触依赖性机制抑制效应细胞的功能，发挥强大的免疫负向调控作用，具有缓解NP的潜力。本文主要综述NP的发生机制，重点探讨Treg细胞、相关介质及其相互作用在NP发生发展中的作用，以期为深入解析NP的病理机制和开发新型治疗策略提供新的思路与潜在靶点。

关键词: 神经病理性疼痛, 调节性T细胞, 免疫调节

Neuropathic pain (NP) has emerged as a major threat to human health, yet its underlying mechanisms remain incompletely understood. Current therapeutic approaches for NP are suboptimal, underscoring the urgency to decipher its potential mechanisms and identify novel therapeutic targets and strategies. Recently, increasing evidence suggests that various immune cells and associated cytokines attach great importance to inhibit nociception and promote the resolution of NP. As a subtype of CD4+T lymphocytes, regulatory T (Treg) cells exert analgesic effects on NP by secreting inhibitory mediators, suppressing effector cells, and other mechanisms. This review synthesizes the latest advances in Treg cells, their cellular mediators, and their interactions in the context of NP, offering new directions and targets for mechanistic research and therapeutic development in this field.

Key words: Neuropathic pain, Regulatory T cells, Immunoregulation mechanism
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