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中华脑科疾病与康复杂志(电子版) ›› 2025, Vol. 15 ›› Issue (04) : 246 -250. doi: 10.3877/cma.j.issn.2095-123X.2025.04.009

综述

脑红蛋白的生理功能及其在临床疾病中的研究现状
程敏1, 吴亚峰2, 韩雅婷1, 郭淮莲1,()   
  1. 1100044 北京,北京大学人民医院神经内科
    2030006 太原,山西省煤炭中心医院神经内科
  • 收稿日期:2024-10-25 出版日期:2025-08-15
  • 通信作者: 郭淮莲

Physiological functions and the current research in clinical diseases of neuroglobin

Min Cheng1, Yafeng Wu2, Yating Han1, Huailian Guo1,()   

  1. 1Department of Neurology, People's Hospital, Peking University, Beijing 100044, China
    2Department of Neuorolgy, Shanxi Coal Central Hospital, Taiyuan 030006, China
  • Received:2024-10-25 Published:2025-08-15
  • Corresponding author: Huailian Guo
引用本文:

程敏, 吴亚峰, 韩雅婷, 郭淮莲. 脑红蛋白的生理功能及其在临床疾病中的研究现状[J/OL]. 中华脑科疾病与康复杂志(电子版), 2025, 15(04): 246-250.

Min Cheng, Yafeng Wu, Yating Han, Huailian Guo. Physiological functions and the current research in clinical diseases of neuroglobin[J/OL]. Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition), 2025, 15(04): 246-250.

脑红蛋白(Ngb)主要存在于神经组织中,是一种内源性神经保护分子,可对抗培养神经元及动物的缺氧缺血和氧化应激相关损伤。在缺氧条件下,Ngb基因及蛋白表达有明显升高,并对细胞的存活有保护作用,可显著保护心脏和大脑免受缺氧、缺血和氧化应激相关伤害,而Ngb水平降低则会导致组织损伤加剧。因此,上调内源性Ngb表达策略有潜在的治疗前景。本文将围绕Ngb的结构、生理功能及保护机制等展开综述,以期为多种临床疾病的治疗提供新的思路。

Neuroglobin (Ngb) is mainly present in neural tissue and is an endogenous neuroprotective molecule that can counteract hypoxic-ischemia and oxidative stress-induced injury in cultured neurons and animals. Its gene and protein expression under hypoxic conditions and has protective effect on cell survival, significantly protecting the heart and brain from hypoxia, ischaemia and oxidative stress-induced injury, whereas reduced levels of Ngb lead to increased tissue damage. Therefore, the strategy of upregulating endogenous Ngb expression has potential therapeutic prospects. This review focuses on the structure, physiological functions and protective mechanisms of Ngb, aiming to provide new ideas for the treatment of various clinical diseases.

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