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中华脑科疾病与康复杂志(电子版) ›› 2017, Vol. 07 ›› Issue (01) : 32 -35. doi: 10.3877/cma.j.issn.2095-123X.2017.01.008

所属专题: 文献

综述

Humanin及其衍生物与认知障碍
张馨娜1, 王涛1, 李洪军1, 孙宝民2, 张新萍1,()   
  1. 1. 271000 山东泰安,泰安市中心医院神经内科
    2. 271000 山东泰安,泰安市中心医院临床心理科
  • 收稿日期:2016-08-08 出版日期:2017-02-01
  • 通信作者: 张新萍
  • 基金资助:
    山东省医药卫生科技发展计划项目(2015WS0119)

Humanin and its derivatives with cognitive impairment

Xinna Zhang1, Tao Wang1, Hongjun Li1, Baomin Sun2, Xinping Zhang1,()   

  1. 1. Department of Neurology, Taian City Central Hospital, Taian 271000, Shandong, China
    2. Department of Clinical Psychology, Taian City Central Hospital, Taian 271000, Shandong, China
  • Received:2016-08-08 Published:2017-02-01
  • Corresponding author: Xinping Zhang
  • About author:
    Corresponding author: Zhang Xinping, Email:
引用本文:

张馨娜, 王涛, 李洪军, 孙宝民, 张新萍. Humanin及其衍生物与认知障碍[J]. 中华脑科疾病与康复杂志(电子版), 2017, 07(01): 32-35.

Xinna Zhang, Tao Wang, Hongjun Li, Baomin Sun, Xinping Zhang. Humanin and its derivatives with cognitive impairment[J]. Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition), 2017, 07(01): 32-35.

阿尔茨海默病(Alzheimer disease,AD)和血管性痴呆(Vascular dementia,VD)是临床最常见的老年痴呆类型,但因缺乏有效的治疗措施而成为严重威胁老年人身心健康和生存质量的主要疾病之一。近来研究表明,Humanin(HN)具有广泛的神经保护作用,除能拮抗β淀粉样蛋白(amyloid beta, Aβ)引起神经细胞损伤外,还能保护缺血引起的PC12细胞的损伤,为开发特异性防治痴呆的新药物带来希望。本文就HN与AD、VD之间的研究进展做一综述。

Alzheimer disease and vascular dementia, known as the most common clinical types of dementia, have became one of the major disease that seriously threaten the physical and mental health and living quality of old people, because of the lack of effective treatment measures. Recent studies have shown that humanin has extensive nerve protective effect, such as lessening injury of PC12 cells caused by ischemia; besides restraining neuron damage caused by amyloid beta. Thus, humanin might bring hope to the development of specific new drugs for the prevention and control of dementia. In this paper, we review the advances in the research between humanin, Alzheimer disease and vascular dementia.

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