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中华脑科疾病与康复杂志(电子版) ›› 2024, Vol. 14 ›› Issue (03) : 177 -181. doi: 10.3877/cma.j.issn.2095-123X.2024.03.009

综述

炎症小体在创伤性脑损伤中作用的研究进展
王燕1, 梁海乾1, 郭姗姗2,†()   
  1. 1. 300162　天津，武警特色医学中心神经外科
    2. 100088　北京，火箭军特色医学中心全科医学科
  • 收稿日期:2023-11-21 出版日期:2024-06-15
  • 通信作者: 郭姗姗

Research advances in role of inflammasome in traumatic brain injury

Yan Wang1, Haiqian Liang1, Shanshan Guo2,†()   

  1. 1. Department of Neurosurgery, Specialized Medical Center of Armed Police Force, Tianjin 300162, China
    2. Department of General Practice, Specialized Medical Center of Rocket Army, Beijing 100088, China
  • Received:2023-11-21 Published:2024-06-15
  • Corresponding author: Shanshan Guo
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王燕, 梁海乾, 郭姗姗. 炎症小体在创伤性脑损伤中作用的研究进展[J]. 中华脑科疾病与康复杂志(电子版), 2024, 14(03): 177-181.

Yan Wang, Haiqian Liang, Shanshan Guo. Research advances in role of inflammasome in traumatic brain injury[J]. Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition), 2024, 14(03): 177-181.

创伤性脑损伤（TBI）具有发病率高、致残率高和死亡率高的特点。神经炎症反应在TBI后继发性脑损伤的病理过程中发挥重要作用，适度的神经炎症反应可以促进组织损伤后细胞碎片清除以及加速损伤神经元修复，但过度的神经炎症反应则会加重细胞损伤，导致神经症状和神经退行性病变。炎症小体是一种蛋白酶复合物，是神经炎症反应的重要组成部分。近年来，随着对炎症小体研究的不断深入，其已被认为是TBI潜在的生物标志物和治疗靶点。本文围绕炎症小体在TBI中的作用及其作为新一代的TBI生物标志物和治疗靶点的潜力展开综述。

关键词: 炎症小体, 创伤性脑损伤, 焦亡, 生物标志物, 治疗靶点

Traumatic brain injury (TBI) is characterized by high incidence, high disability and high mortality. Neuroinflammatory response plays an important role in the pathological process of secondary brain injury. Moderate neuroinflammatory response can promote the removal of cell debris after tissue injury and accelerate the repair of injured neurons, but excessive neuroinflammatory response can also aggravate cell injury and lead to neurological symptoms and neurodegeneration. The inflammasome is a protease complex that is an important component of the neuroinflammatory response. In recent years, with the deepening of the research on inflammasome, inflammasome has been considered as a potential biomarker and therapeutic target for TBI. This review focuses on the role of inflammasome in TBI and its potential as a new generation biomarker and therapeutic target in TBI.

Key words: Inflammasome, Traumatic brain injury, Pyroptosis, Biomarkers, Therapeutic targets
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